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Chemical Compound Review

AC1NSNZH     (6E,8E,10E,14E)-5,12- dihydroxyicosa-6,8,10...

Synonyms: D3413_SIGMA, LMFA03060052, AR-1G5777, AC1Q5VZ9, 5,12-Di-HETE, ...
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Disease relevance of LMFA03060052


High impact information on LMFA03060052


Associations of LMFA03060052 with other chemical compounds

  • Only 5,12-di-HETE released significant quantities of beta-glucuronidase and lysozyme from the neutrophils, but the maximal level of enzyme release was far less than that for the chemotactic fragment of C5 and the formyl-methionyl peptides [4].


  1. Neutropenia induced by systemic infusion of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid: correlation with its in vitro effects upon neutrophils. O'Flaherty, J.T., Thomas, M.J., Cousart, S.L., Salzer, W.L., McCall, C.E. J. Clin. Invest. (1982) [Pubmed]
  2. Functional characterization of synthetic leukotriene B and its stereochemical isomers. Lewis, R.A., Goetzl, E.J., Drazen, J.M., Soter, N.A., Austen, K.F., Corey, E.J. J. Exp. Med. (1981) [Pubmed]
  3. Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway. Claeys, M., Kivits, G.A., Christ-Hazelhof, E., Nugteren, D.H. Biochim. Biophys. Acta (1985) [Pubmed]
  4. The human PMN leukocyte chemotactic activity of complex hydroxy-eicosatetraenoic acids (HETEs). Goetzl, E.J., Pickett, W.C. J. Immunol. (1980) [Pubmed]
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