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Chemical Compound Review:

AC1NSNZH (6E,8E,10E,14E)-5,12- dihydroxyicosa-6,8,10...

Synonyms: D3413_SIGMA, LMFA03060052, AR-1G5777, AC1Q5VZ9, 5,12-Di-HETE, ...

Claeys, M. et al., Lewis, R.A. et al., Goetzl, E.J. et al., O'Flaherty, J.T. et al.

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Disease relevance of LMFA03060052

Neutropenia induced by systemic infusion of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid: correlation with its in vitro effects upon neutrophils [1].

High impact information on LMFA03060052

Leukotriene B (LTB), a potent lipid chemotactic factor for neutrophils, is 5S,12R-dihydroxy-6,14-cis,8,10-trans-eicosatetraenoic acid (Fig 1), based upon direct comparison of natural LTB with synthetic 5S,12R-dihydroxy-6,8,10,14-eicosatetraenoic acid (5,12-di-HETE) stereoisomers in three biological assays [2].
Porcine neutrophilic leukocytes were found to contain a lipoxygenase which converted linoleic acid into 13-hydroxy-9,11-octadecadienoic acid (n-6 specificity), arachidonic acid into 12-hydroxy-5,8,10,14-eicosatetraenoic acid (n - 9 specificity) and 5-hydroxy-6,8,11,14-eicosatetraenoic acid into 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid [3].

Associations of LMFA03060052 with other chemical compounds

Only 5,12-di-HETE released significant quantities of beta-glucuronidase and lysozyme from the neutrophils, but the maximal level of enzyme release was far less than that for the chemotactic fragment of C5 and the formyl-methionyl peptides [4].

References

Neutropenia induced by systemic infusion of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid: correlation with its in vitro effects upon neutrophils. O'Flaherty, J.T., Thomas, M.J., Cousart, S.L., Salzer, W.L., McCall, C.E. J. Clin. Invest. (1982) [Pubmed]
Functional characterization of synthetic leukotriene B and its stereochemical isomers. Lewis, R.A., Goetzl, E.J., Drazen, J.M., Soter, N.A., Austen, K.F., Corey, E.J. J. Exp. Med. (1981) [Pubmed]
Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway. Claeys, M., Kivits, G.A., Christ-Hazelhof, E., Nugteren, D.H. Biochim. Biophys. Acta (1985) [Pubmed]
The human PMN leukocyte chemotactic activity of complex hydroxy-eicosatetraenoic acids (HETEs). Goetzl, E.J., Pickett, W.C. J. Immunol. (1980) [Pubmed]

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