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Chemical Compound Review

12-R-Hete     (5E,8E,10E,14E)-12- hydroxyicosa-5,8,10,14...

Synonyms: CHEBI:19138, AC1Q5VZZ, AR-1C0663, FT-0641326, AC1NS3ZH, ...
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Disease relevance of 12-R-Hete


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Chemical compound and disease context of 12-R-Hete


Biological context of 12-R-Hete


Anatomical context of 12-R-Hete


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Analytical, diagnostic and therapeutic context of 12-R-Hete


  1. 12-Lipoxygenase isoenzymes in mouse skin tumor development. Krieg, P., Kinzig, A., Ress-Löschke, M., Vogel, S., Vanlandingham, B., Stephan, M., Lehmann, W.D., Marks, F., Fürstenberger, G. Mol. Carcinog. (1995) [Pubmed]
  2. Stereochemical difference between 12-hydroxy-5,8,10,14-eicosatetraenoic acid in platelets and psoriatic lesions. Woollard, P.M. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  3. A comparison of the proinflammatory effects of 12(R)- and 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid in human skin. Wollard, P.M., Cunnigham, F.M., Murphy, G.M., Camp, R.D., Derm, F.F., Greaves, M.W. Prostaglandins (1989) [Pubmed]
  4. 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid is a chemoattractant for human polymorphonuclear leucocytes in vitro. Cunningham, F.M., Woollard, P.M. Prostaglandins (1987) [Pubmed]
  5. Effects of oxo and dihydro metabolites of 12-hydroxy-5,8,10,14-eicosatetraenoic acid on chemotaxis and cytosolic calcium levels in human neutrophils. Powell, W.S., Hashefi, M., Falck, J.R., Chauhan, K., Rokach, J., Wang, S.S., Mills, E., MacLeod, R.J. J. Leukoc. Biol. (1995) [Pubmed]
  6. 12-Hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) does not stimulate proliferation of human neonatal keratinocytes. Otto, W.R., Barr, R.M., Dowd, P.M., Wright, N.A., Greaves, M.W. J. Invest. Dermatol. (1989) [Pubmed]
  7. Flavonoid potentiation of contractile responses in rat blood vessels. Berger, M.E., Golub, M.S., Chang, C.T., al-Kharouf, J.A., Nyby, M.D., Hori, M., Brickman, A.S., Tuck, M.L. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  8. Isomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid reduce renin activity and increase water and electrolyte excretion. Quilley, C.P., McGiff, J.C. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  9. 12- and 15-lipoxygenases in rat pineal gland. Yoshimoto, T., Kusaka, M., Shinjo, F., Yamamoto, S., Dray, F. Prostaglandins (1984) [Pubmed]
  10. Cutaneous responses to 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) and 5,12-dihydroxyeicosatetraenoic acid (leukotriene B4) in psoriasis and normal human skin. Dowd, P.M., Black, A.K., Woollard, P.W., Greaves, M.W. Arch. Dermatol. Res. (1987) [Pubmed]
  11. The effects of xanthoangelol E on arachidonic acid metabolism in the gastric antral mucosa and platelet of the rabbit. Fujita, T., Sakuma, S., Sumiya, T., Nishida, H., Fujimoto, Y., Baba, K., Kozawa, M. Res. Commun. Chem. Pathol. Pharmacol. (1992) [Pubmed]
  12. Lipid chemotaxins isolated from culture filtrates of Escherichia coli and from oxidized lipids. Sahu, S., Lynn, W.S. Inflammation (1977) [Pubmed]
  13. Transfomration of arachidonic acid into 12-hydroxy-5,8,10,14-eicosatetraenoic acid by mouse peritoneal macrophages. Rigaud, M., Durand, J., Breton, J.C. Biochim. Biophys. Acta (1979) [Pubmed]
  14. Arachidonic acid metabolism in isolated pancreatic islets. V. The enantiomeric composition of 12-hydroxy-5,8,10,14-eicosatetraenoic acid indicates synthesis by a 12-lipoxygenase rather than a monooxygenase. Turk, J., Wolf, B.A., Easom, R.A., Hughes, J.H., McDaniel, M.L. Biochim. Biophys. Acta (1989) [Pubmed]
  15. Lipoxygenase activity in human uterine and intrauterine tissues: new prospects for control of prostacyclin production in pre-eclampsia. Saeed, S.A., Mitchell, M.D. Clinical and experimental hypertension. Part B, Hypertension in pregnancy. (1983) [Pubmed]
  16. Partial purification and characterization of arachidonate 12-lipoxygenase from rat lung. Yokoyama, C., Mizuno, K., Mitachi, H., Yoshimoto, T., Yamamoto, S., Pace-Asciak, C.R. Biochim. Biophys. Acta (1983) [Pubmed]
  17. Prostaglandin thromboxane, and 12-hydroxy-5,8,10,14-eicosatetraenoic acid production by ionophore-stimulated rat serosal mast cells. Roberts, L.J., Lewis, R.A., Oates, J.A., Austen, K.F. Biochim. Biophys. Acta (1979) [Pubmed]
  18. Identification of lipoxygenase products from arachidonic acid metabolism in stimulated murine eosinophils. Turk, J., Rand, T.H., Maas, R.L., Lawson, J.A., Brash, A.R., Roberts, L.J., Colley, D.G., Oates, J.A. Biochim. Biophys. Acta (1983) [Pubmed]
  19. Interference of the new antiinflammatory compound flunoxaprofen with eicosanoid formation in various biological systems. Berti, F., Galli, G., Omini, C., Rossoni, G., Brunelli, G., Daffonchio, L., Viganò, T., Magni, F., Crivellari, M.T., Forgione, A. Arzneimittel-Forschung. (1987) [Pubmed]
  20. In vivo transformation of arachidonic acid into 12-hydroxy-5,8,10,14-eicosatetraenoic acid by human nasal mucosa. Ramis, I., Roselló-Catafau, J., Gelpí, E. J. Chromatogr. (1992) [Pubmed]
  21. Temporal changes in 12-HETE formation in two models of canine myocardial infarction. McCluskey, E.R., Murphree, S., Saffitz, J.E., Morrison, A.R., Needleman, P. Prostaglandins (1985) [Pubmed]
  22. Metabolism of [1-14C]-arachidonic acid by cultured calf aortic endothelial cells: evidence for the presence of a lipoxygenase pathway. Kühn, H., Pönicke, K., Halle, W., Wiesner, R., Schewe, T., Förster, W. Prostaglandins, leukotrienes, and medicine. (1985) [Pubmed]
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