Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1NSWGP (E)-3-(2-hydroxyphenyl)prop- 2-enal

Synonyms: CHEMBL52569, AC1Q6PPM, LS-53831, AR-1E6306, AKOS004118471, ...

Lee, S.H. et al., Kim, S.Y. et al., Han, D.C. et al., Lee, S.H. et al., Kwon, B.M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of o-Hydroxycinnamaldehyde

Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells [1].

High impact information on o-Hydroxycinnamaldehyde

2'-hydroxycinnamaldehyde (HCA) has been shown to have inhibitory effects on farnesyl protein transferase in vitro, angiogenesis, and tumor cell growth [2].
Inhibitory effect of 2'-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells [3].
2'-Hydroxycinnamaldehyde from Stem Bark of Cinnamomum cassia [4].
2'-Benzoyloxycinnamaldehyde (BCA), a derivative of 2-hydroxycinnamaldehyde demonstrated a potent antitumor effect against several human solid tumor cell lines [5].

References

Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells. Lee, S.H., Lee, C.W., Lee, J.W., Choi, M.S., Son, D.J., Chung, Y.B., Lee, C.K., Oh, K.W., Moon, D.C., Kwon, B.M., Hong, J.T. Biochem. Pharmacol. (2005) [Pubmed]
2'-benzoyloxycinnamaldehyde induces apoptosis in human carcinoma via reactive oxygen species. Han, D.C., Lee, M.Y., Shin, K.D., Jeon, S.B., Kim, J.M., Son, K.H., Kim, H.C., Kim, H.M., Kwon, B.M. J. Biol. Chem. (2004) [Pubmed]
Inhibitory effect of 2'-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells. Lee, S.H., Lee, S.Y., Son, D.J., Lee, H., Yoo, H.S., Song, S., Oh, K.W., Han, D.C., Kwon, B.M., Hong, J.T. Biochem. Pharmacol. (2005) [Pubmed]
2'-Hydroxycinnamaldehyde from Stem Bark of Cinnamomum cassia. Kwon, B.M., Cho, Y.K., Lee, S.H., Nam, J.Y., Bok, S.H., Chen, S.K., Kim, J.A., Lee, I.R. Planta Med. (1996) [Pubmed]
Physicochemical properties of 2'-benzoyloxycinnamaldehyde. Kim, S.Y., Lee, K.J., Shin, Y.H., Lee, C.H. International journal of pharmaceutics. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share