Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Spiraein 3,5,7-trihydroxy-2-[3- hydroxy-4-[(2S,3R,4S...

Synonyms: Spiraeosid, Spireoside, Spiraeoside, AC1NSZXI, CHEMBL402947, ...

Day, A.J. et al., Mullen, W. et al., Olthof, M.R. et al., Popp, R. et al., Boyer, J. et al., et al.

Boyer, Brown, Liu, Day, Gee, DuPont, Johnson, Williamson,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Spiraein

Of the glycosides, only quercetin-4'-glucoside was able to induce QR activity in this assay [1].
Evidently the mechanism of absorption of quercetin-4'-glucoside involves both an interaction with SGLT1 and luminal hydrolysis by LPH, whereas quercetin-3-glucoside appears to be absorbed only following hydrolysis by LPH [2].
We studied whether this 3-glucoside has the same high bioavailability as the quercetin-4'-glucoside [3].
The aglycones as well as the C-glycosides and the O-glycosides, spiraeoside and luteolin-7-glucoside, were more or less active in inducing micronuclei in the lymphocytes [4].
Lightly fried onions containing 275 micromol flavonols, principally quercetin-4'-glucoside and quercetin-3,4'-diglucoside, were fed to healthy human volunteers and plasma and urine were collected over a 24 h period [5].

Anatomical context of Spiraein

Digestion increased the Caco-2 cell uptake of shallot quercetin-4'-glucoside by 2-fold when compared to the non-digested shallot [6].

Associations of Spiraein with other chemical compounds

Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans [3].

References

Dietary quercetin glycosides: antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells. Williamson, G., Plumb, G.W., Uda, Y., Price, K.R., Rhodes, M.J. Carcinogenesis (1996) [Pubmed]
Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Day, A.J., Gee, J.M., DuPont, M.S., Johnson, I.T., Williamson, G. Biochem. Pharmacol. (2003) [Pubmed]
Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans. Olthof, M.R., Hollman, P.C., Vree, T.B., Katan, M.B. J. Nutr. (2000) [Pubmed]
Induction of sister-chromatid exchanges (SCE), polyploidy, and micronuclei by plant flavonoids in human lymphocyte cultures. A comparative study of 19 flavonoids. Popp, R., Schimmer, O. Mutat. Res. (1991) [Pubmed]
Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. Mullen, W., Edwards, C.A., Crozier, A. Br. J. Nutr. (2006) [Pubmed]
In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. Boyer, J., Brown, D., Liu, R.H. Nutrition journal [electronic resource]. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.