The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound

Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

[search][options]

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Popp, R. et al.

Induction of sister-chromatid exchanges (SCE), polyploidy, and micronuclei by plant flavonoids in human lymphocyte cultures. A comparative study of 19 flavonoids.

Nineteen naturally occurring flavonoids were studied with regard to their SCE-inducing potency and their capability of inducing polyploidy and micronuclei in human lymphocyte cultures. The cells were treated for a period of 48 h. The flavone C-glycosides, vitexin and orientin, exhibited a moderate SCE-inducing activity, whereas the other compounds displayed only weak effects or were inactive. Polyploidy was induced by procyanidins consisting of 3 or 4 flavanol units and to a lesser extent by flavone, flavonol, and anthocyanidin aglycones. The aglycones as well as the C-glycosides and the O-glycosides, spiraeoside and luteolin-7-glucoside, were more or less active in inducing micronuclei in the lymphocytes. The flavonol O-glycosides, rutin and hyperoside, and the monomeric and dimeric flavanols failed to produce any genotoxic effects. The results are discussed with respect to a possible structure-activity relationship.[1]

References

Induction of sister-chromatid exchanges (SCE), polyploidy, and micronuclei by plant flavonoids in human lymphocyte cultures. A comparative study of 19 flavonoids. Popp, R., Schimmer, O. Mutat. Res. (1991) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg