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Chemical Compound Review

SureCN8346701     (2E)-2-[(3,4-dihydroxyphenyl) methylidene]...

Synonyms: NSC-226214, NSC226214, ZINC00897734, LS-191156, FT-0631687, ...
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Disease relevance of Sulfuretin

  • Since treatment with sulfuretin and the EtOAc extract decreased the concentration of infiltrated mast cells in the rat knee exhibiting rheumatoid arthritis, we suggest that the Rhus verniciflua extract, which contains sulfuretin as an active component, may prevent rheumatoid syndromes by inhibiting reactive oxygen species [1].

High impact information on Sulfuretin

  • Oral administration (30 mg/kg) of sulfuretin and fustin, which were isolated from the EtOAc extract by activity-guided separation, significantly decreased RA and CRP factors, the former being more active than the latter [1].
  • Biocatalytic synthesis of butein and sulfuretin by Aspergillus alliaceus [2].
  • When these components were subjected to the Ames test, it was found that sulfuretin might effectively prevent the metabolic activation or scavenge electrophilic intermediates capable of causing mutation [3].


  1. Antirheumatoid arthritis effect of Rhus verniciflua and of the active component, sulfuretin. Choi, J., Yoon, B.J., Han, Y.N., Lee, K.T., Ha, J., Jung, H.J., Park, H.J. Planta Med. (2003) [Pubmed]
  2. Biocatalytic synthesis of butein and sulfuretin by Aspergillus alliaceus. Sanchez-Gonzalez, M., Rosazza, J.P. J. Agric. Food Chem. (2006) [Pubmed]
  3. Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua. Park, K.Y., Jung, G.O., Lee, K.T., Choi, J., Choi, M.Y., Kim, G.T., Jung, H.J., Park, H.J. Journal of ethnopharmacology. (2004) [Pubmed]
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