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Chemical Compound Review

Lipoxin B     (6E,8E,10E,12E)-5,14,15- trihydroxyicosa-6...

Synonyms: LXB4, lipoxin B4, LMFA01030749, LS-178193, AC1NS4IH, ...
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High impact information on Lipoxin B


Anatomical context of Lipoxin B


Associations of Lipoxin B with other chemical compounds

  • The complete steric structure of the major tetraene product (lipoxin B methyl ester) was established by ultraviolet spectroscopy, HPLC on four different types of columns, gas chromatography/mass spectrometry, gas/liquid chromatography of the ozonolysis fragments of the menthoxycarbonyl derivatives, and by 400-MHz 1H-NMR [6].
  • The complete stereochemistry of the lipoxin B formed from 15S-HETE methyl ester has been established by co-chromatography with authentic standards on various types of HPLC columns, by GC/MS analysis, by gas liquid chromatography of the ozonolysis fragments of the menthoxy carbonyl derivatives and 1H-NMR studies [7].


  1. Action of novel eicosanoids lipoxin A and B on human natural killer cell cytotoxicity: effects on intracellular cAMP and target cell binding. Ramstedt, U., Ng, J., Wigzell, H., Serhan, C.N., Samuelsson, B. J. Immunol. (1985) [Pubmed]
  2. Lipoxin generation by permeabilized human platelets. Romano, M., Serhan, C.N. Biochemistry (1992) [Pubmed]
  3. Formation of lipoxin B by the pure reticulocyte lipoxygenase. Kühn, H., Wiesner, R., Alder, L., Schewe, T., Stender, H. FEBS Lett. (1986) [Pubmed]
  4. A phospholipase A2 isoenzyme provokes lipoxin B formation from endogenous sources of arachidonic acid in porcine leukocytes. Lam, B.K., Serhan, C.N., Samuelsson, B., Wong, P.Y. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  5. The effects of lipoxin A and lipoxin B on functional responses of human granulocytes. Palmblad, J., Gyllenhammar, H., Ringertz, B., Serhan, C.N., Samuelsson, B., Nicolaou, K.C. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  6. Formation of lipoxin B by the pure reticulocyte lipoxygenase via sequential oxygenation of the substrate. Kühn, H., Wiesner, R., Alder, L., Fitzsimmons, B.J., Rokach, J., Brash, A.R. Eur. J. Biochem. (1987) [Pubmed]
  7. Lipoxygenase catalyzed oxygenation of hydroxy fatty acids to lipoxins. Kühn, H., Brash, A.R., Wiesner, R., Alder, L. Adv. Exp. Med. Biol. (1988) [Pubmed]
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