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Chemical Compound Review:

Irtran-1 magnesium difluoride

Synonyms: AC1NSEH7, ACMC-1BEVI, AG-H-11841, AC1L2NID, CTK2H8553, ...

Kousa, A. et al., Danko, S. et al., Toyoshima, C. et al., Graham, D.L. et al., Johnson, E.N. et al., et al.

Kousa, Moltchanova, Viik-Kajander, Rytkönen, Tuomilehto, Tarvainen, Karvonen,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Afluon

Inhibition of the ATPase activity of Escherichia coli ATP synthase by magnesium fluoride [1].
STUDY OBJECTIVE: To examine the association of spatial variation in acute myocardial infarction (AMI) incidence and its putative environmental determinants in ground water such as total water hardness, the concentration of calcium, magnesium, fluoride, iron, copper, zinc, nitrate, and aluminium [2].

High impact information on Afluon

Distinct natures of beryllium fluoride-bound, aluminum fluoride-bound, and magnesium fluoride-bound stable analogues of an ADP-insensitive phosphoenzyme intermediate of sarcoplasmic reticulum Ca2+-ATPase: changes in catalytic and transport sites during phosphoenzyme hydrolysis [3].
RGS13 binds Galpha(q) in the presence of aluminum magnesium fluoride, suggesting that it bears GTPase-activating protein activity toward Galpha(q) [4].
Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins [5].
Thus, either aluminum fluoride or magnesium fluoride can mediate the high-affinity binding of Rho [5].
Here we report at 2.3 A resolution the structure of the calcium-ATPase of skeletal muscle sarcoplasmic reticulum, a representative P-type ATPase that is crystallized in the absence of Ca2+ but in the presence of magnesium fluoride, a stable phosphate analogue [6].

Biological context of Afluon

Contrast sensitivity was measured to quantify the glare-reducing effects of antireflective coatings of magnesium fluoride on spectacle lenses [7].

References

Inhibition of the ATPase activity of Escherichia coli ATP synthase by magnesium fluoride. Ahmad, Z., Senior, A.E. FEBS Lett. (2006) [Pubmed]
Geochemistry of ground water and the incidence of acute myocardial infarction in Finland. Kousa, A., Moltchanova, E., Viik-Kajander, M., Rytkönen, M., Tuomilehto, J., Tarvainen, T., Karvonen, M. Journal of epidemiology and community health. (2004) [Pubmed]
Distinct natures of beryllium fluoride-bound, aluminum fluoride-bound, and magnesium fluoride-bound stable analogues of an ADP-insensitive phosphoenzyme intermediate of sarcoplasmic reticulum Ca2+-ATPase: changes in catalytic and transport sites during phosphoenzyme hydrolysis. Danko, S., Yamasaki, K., Daiho, T., Suzuki, H. J. Biol. Chem. (2004) [Pubmed]
Functional characterization of the G protein regulator RGS13. Johnson, E.N., Druey, K.M. J. Biol. Chem. (2002) [Pubmed]
Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins. Graham, D.L., Eccleston, J.F., Chung, C.W., Lowe, P.N. Biochemistry (1999) [Pubmed]
Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues. Toyoshima, C., Nomura, H., Tsuda, T. Nature (2004) [Pubmed]
Improved contrast sensitivity with antireflective coated lenses in the presence of glare. Coupland, S.G., Kirkham, T.H. Can. J. Ophthalmol. (1981) [Pubmed]

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