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Gene Review:

RGS13 - regulator of G-protein signaling 13

Homo sapiens

Synonyms: Regulator of G-protein signaling 13

Johnson, E.N. et al., Han, J.I. et al., Islam, T.C. et al.

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Disease relevance of RGS13

RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization [1].
Two of these proteins, RGS1 and RGS13, are well-expressed in germinal center B cells and many Burkitt's lymphoma cell lines [1].

High impact information on RGS13

Functional characterization of the G protein regulator RGS13 [2].
RGS13 is a GTPase-activating protein for Galpha(i) and Galpha(o) but not Galpha(s) [2].
RGS13 also attenuates GTPase-deficient Galpha(q) (Galpha(q)QL) mediated cAMP response element activation but not transcription evoked by constitutively active Galpha(12) or Galpha(13) [2].
RGS13 has been found most abundantly in human tonsil, followed by thymus, lung, lymph node, and spleen [2].
These results indicate that RGS1 and RGS13 act together to regulate chemokine receptor signaling in human germinal center B lymphocytes and provide evidence that they contribute significantly to the rapid desensitization of the signaling pathway [1].

Biological context of RGS13

Sequencing of the RGS13 gene revealed changes suggesting polymorphisms, indicating that downregulation of the expression of RGS13 is not related to mutations, but may serve as a new specific marker for MCL [3].

Anatomical context of RGS13

Furthermore, there was a reduced expression of a regulator of G protein signalling, RGS13 in all MCLs, with a complete absence in the majority of cases while present in control lymphoid tissue [3].

Associations of RGS13 with chemical compounds

RGS13 binds Galpha(q) in the presence of aluminum magnesium fluoride, suggesting that it bears GTPase-activating protein activity toward Galpha(q) [2].

References

RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. Han, J.I., Huang, N.N., Kim, D.U., Kehrl, J.H. J. Leukoc. Biol. (2006) [Pubmed]
Functional characterization of the G protein regulator RGS13. Johnson, E.N., Druey, K.M. J. Biol. Chem. (2002) [Pubmed]
High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma. Islam, T.C., Asplund, A.C., Lindvall, J.M., Nygren, L., Liden, J., Kimby, E., Christensson, B., Smith, C.I., Sander, B. Leukemia (2003) [Pubmed]

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RGS13	Canis lupus familiaris
RGS13	Gallus gallus
LOC712688	Macaca mulatta
Rgs13	Mus musculus
RGS13	Pan troglodytes
Rgs13	Rattus norvegicus
rgs13	Xenopus (Silurana) tropicalis

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