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Chemical Compound Review

Cladinose     (3R,4S,5S)-4,5-dihydroxy-3- methoxy-3...

Synonyms: L-Cladinose, AC1NUTFI, CHEBI:29612, FT-0665074, C11917
 
 
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Disease relevance of L-Cladinose

  • In the search for new antibiotics active against macrolide-resistant pneumococci and Haemophilus influenzae, we synthesized a new class of 3-oxo-6-O-methylerythromycin derivatives, so-called "ketolides". A keto function was introduced in position 3 after removal of L-cladinose, a sugar which has long been thought essential [1].
 

High impact information on L-Cladinose

  • Erythromycin A-derived macrolides modify the functional activities of human neutrophils by altering the phospholipase D-phosphatidate phosphohydrolase transduction pathway: L-cladinose is involved both in alterations of neutrophil functions and modulation of this transductional pathway [2].
  • The ability of these molecules and their L-cladinose counterparts to induce MLS(B) resistance in staphylococci (one strain) and streptococci (two strains) was investigated using a disc agar susceptibility method as well as measuring induction kinetics [3].
  • We and others have previously reported that erythromycin A-derived macrolides impair the phagocyte oxidative burst, a property linked to the presence of L-cladinose [4].
  • Cladinose analogues of sixteen-membered macrolide antibiotics. V. Preparation of unsubstituted L-cladinose analogues: effect of methylation of a 3"-hydroxyl group on the bioactivity [5].
 

Biological context of L-Cladinose

  • We demonstrate in this study that the L-cladinose at position 3 of the lactone ring is a key structure in the modulation of these two neutrophil functions, suggesting that this sugar (alone or combined with a lactone structure) interferes with cell target(s) involved in both oxidant production and exocytosis [2].

References

  1. Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. Agouridas, C., Denis, A., Auger, J.M., Benedetti, Y., Bonnefoy, A., Bretin, F., Chantot, J.F., Dussarat, A., Fromentin, C., D'Ambrières, S.G., Lachaud, S., Laurin, P., Le Martret, O., Loyau, V., Tessot, N. J. Med. Chem. (1998) [Pubmed]
  2. Erythromycin A-derived macrolides modify the functional activities of human neutrophils by altering the phospholipase D-phosphatidate phosphohydrolase transduction pathway: L-cladinose is involved both in alterations of neutrophil functions and modulation of this transductional pathway. Abdelghaffar, H., Vazifeh, D., Labro, M.T. J. Immunol. (1997) [Pubmed]
  3. Ketolides lack inducibility properties of MLS(B) resistance phenotype. Bonnefoy, A., Girard, A.M., Agouridas, C., Chantot, J.F. J. Antimicrob. Chemother. (1997) [Pubmed]
  4. Structure-activity relationships among 9-N-alkyl derivatives of erythromycylamine and their effect on the oxidative burst of human neutrophils in vitro. Abdelghaffar, H., Kirst, H., Soukri, A., Babin-Chevaye, C., Labro, M.T. Journal of chemotherapy (Florence, Italy) (2002) [Pubmed]
  5. Cladinose analogues of sixteen-membered macrolide antibiotics. V. Preparation of unsubstituted L-cladinose analogues: effect of methylation of a 3"-hydroxyl group on the bioactivity. Ajito, K., Shimizu, A., Shibahara, S., Hara, O., Kurihara, K., Araake, M., Tohyama, K., Miyadoh, S., Omoto, S., Inouye, S. J. Antibiot. (1997) [Pubmed]
 
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