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Chemical Compound Review:

Lignocerat tetracosanoate

Synonyms: lignocerate, tetracosoate, Tetracosanoat, tetracosanate, DECYLMYRISTATE, ...

This record was replaced with 11197.

Wanders, R.J. et al., Boles, D.J. et al., Michels, V.V. et al., Steinberg, S.J. et al., Kodali, D.R. et al.

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Disease relevance of tetracosanoic acid

The peroxisomal oxidation of the long chain fatty acid palmitate (C16:0) and the very long chain fatty acids lignocerate (C24:0) and cerotate (C26:0) was studied in freshly prepared homogenates of cultured skin fibroblasts from control individuals and patients with peroxisomal disorders [1].

High impact information on tetracosanoic acid

3-Acyl-sn-glycerols with even-numbered saturated fatty acyl chains from decanoate to lignocerate were synthesized [2].
Because cholesteryl esters with very long chain fatty acids accumulate in Schilder adrenoleukodystrophy, the ability of extracts of such fibroblasts to hydrolyze [14C]cholesteryl lignocerate was examined [3].
COS-1 cells transiently overexpressing hVLCS-H2 activated the very-long-chain fatty acid lignocerate (C24:0) at a rate >1.5-fold higher than that of nontransfected cells (P < 0.002) [4].

Associations of tetracosanoic acid with other chemical compounds

With the use of fibroblast homogenates, oxidation of lignocerate was partially inhibited by various long-chain fatty acids, and residual activity in ALD homogenates was more susceptible to inhibition by palmitate than normal [5].

References

Peroxisomal fatty acid beta-oxidation in relation to the accumulation of very long chain fatty acids in cultured skin fibroblasts from patients with Zellweger syndrome and other peroxisomal disorders. Wanders, R.J., van Roermund, C.W., van Wijland, M.J., Schutgens, R.B., Heikoop, J., van den Bosch, H., Schram, A.W., Tager, J.M. J. Clin. Invest. (1987) [Pubmed]
Synthesis and polymorphism of 3-acyl-sn-glycerols. Kodali, D.R., Redgrave, T.G., Small, D.M., Atkinson, D. Biochemistry (1985) [Pubmed]
Cholesteryl lignocerate hydrolysis in adrenoleukodystrophy. Michels, V.V., Beaudet, A.L. Pediatr. Res. (1980) [Pubmed]
Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. Steinberg, S.J., Wang, S.J., McGuinness, M.C., Watkins, P.A. Mol. Genet. Metab. (1999) [Pubmed]
Clinical variation in X-linked adrenoleukodystrophy: fatty acid and lipid metabolism in cultured fibroblasts. Boles, D.J., Craft, D.A., Padgett, D.A., Loria, R.M., Rizzo, W.B. Biochem. Med. Metab. Biol. (1991) [Pubmed]

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