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Chemical Compound Review

Lignocerat     tetracosanoate

Synonyms: lignocerate, tetracosoate, Tetracosanoat, tetracosanate, DECYLMYRISTATE, ...
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Disease relevance of tetracosanoic acid


High impact information on tetracosanoic acid

  • 3-Acyl-sn-glycerols with even-numbered saturated fatty acyl chains from decanoate to lignocerate were synthesized [2].
  • Because cholesteryl esters with very long chain fatty acids accumulate in Schilder adrenoleukodystrophy, the ability of extracts of such fibroblasts to hydrolyze [14C]cholesteryl lignocerate was examined [3].
  • COS-1 cells transiently overexpressing hVLCS-H2 activated the very-long-chain fatty acid lignocerate (C24:0) at a rate >1.5-fold higher than that of nontransfected cells (P < 0.002) [4].

Associations of tetracosanoic acid with other chemical compounds

  • With the use of fibroblast homogenates, oxidation of lignocerate was partially inhibited by various long-chain fatty acids, and residual activity in ALD homogenates was more susceptible to inhibition by palmitate than normal [5].


  1. Peroxisomal fatty acid beta-oxidation in relation to the accumulation of very long chain fatty acids in cultured skin fibroblasts from patients with Zellweger syndrome and other peroxisomal disorders. Wanders, R.J., van Roermund, C.W., van Wijland, M.J., Schutgens, R.B., Heikoop, J., van den Bosch, H., Schram, A.W., Tager, J.M. J. Clin. Invest. (1987) [Pubmed]
  2. Synthesis and polymorphism of 3-acyl-sn-glycerols. Kodali, D.R., Redgrave, T.G., Small, D.M., Atkinson, D. Biochemistry (1985) [Pubmed]
  3. Cholesteryl lignocerate hydrolysis in adrenoleukodystrophy. Michels, V.V., Beaudet, A.L. Pediatr. Res. (1980) [Pubmed]
  4. Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. Steinberg, S.J., Wang, S.J., McGuinness, M.C., Watkins, P.A. Mol. Genet. Metab. (1999) [Pubmed]
  5. Clinical variation in X-linked adrenoleukodystrophy: fatty acid and lipid metabolism in cultured fibroblasts. Boles, D.J., Craft, D.A., Padgett, D.A., Loria, R.M., Rizzo, W.B. Biochem. Med. Metab. Biol. (1991) [Pubmed]
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