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Gene Review

SLC27A5  -  solute carrier family 27 (fatty acid...

Homo sapiens

Synonyms: ACSB, ACSVL6, BA-CoA ligase, BACS, BAL, ...
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Disease relevance of SLC27A5

  • We have applied a comprehensive panel of markers to patients with chronic renal failure (CRF), with particular focus on the isoforms of bone alkaline phosphatase (BALP) [1].
  • Remarkably, anti-IL-17 mAb significantly enhanced IL-5 levels in both BAL fluid and serum, and aggravated allergen-induced bronchial eosinophilia [2].
  • Serum and BAL macrophage migration inhibitory factor levels in HIV infected Tanzanians with pulmonary tuberculosis or other lung diseases [3].
  • This study compared the BALP isoform in the serum of patients with cholangiocarcinoma (CCA) with that of non-jaundiced benign hepatobiliary disease, other cancers, and healthy persons [4].
  • Biliary alkaline phosphatase (BALP), an isoform of liver-ALP, has been found in the serum of patients with biliary obstruction and metastatic liver cancer [4].

High impact information on SLC27A5

  • When expressed in COS-1 cells, hVLCS-H2 exhibited cholate:CoA ligase (choloyl-CoA synthetase) activity with both non-isotopic and radioactive assays [5].
  • A human homolog of very long-chain acyl-CoA synthetase, hVLCS-H2, has two requisite properties of a bile acid:CoA ligase, liver specificity and an endoplasmic reticulum subcellular localization [5].
  • Our results are consistent with a role for hVLCS-H2 in the re-activation and re-conjugation of bile acids entering liver from the enterohepatic circulation rather than in de novo bile acid synthesis [5].
  • Stress significantly increased allergen induced airway inflammation as identified by leukocyte numbers in BAL fluids [6].
  • BAT correlated significantly with BAL/BAE for PHT (r = 0.44, p = 0.02) and CBZ (r = 0.42, p = 0.03) but not for NC (r = 0.03, p = NS) and LTG (r = 0.06, p = NS) groups [7].

Chemical compound and disease context of SLC27A5

  • As bone resorption markers, urinary free and total deoxypyridinoline as well as urinary collagen type I C-terminal telopeptide were measured; as bone formation markers, serum bone type and total alkaline phosphatase (BALP and ALP) levels along with osteocalcin (OC) were used [8].

Biological context of SLC27A5


Anatomical context of SLC27A5

  • The SEB-induced neutrophil accumulation in BAL fluid was reduced by pretreatment with dexamethasone (0.5 mg/kg), the COX-2 inhibitor celecoxib (3 mg/kg), the selective iNOS inhibitor compound 1400 W (5 mg/kg) and the lipoxygenase inhibitor AA-861 (200 mug/kg) [11].
  • Airways exposition to SEB (7.5-250 ng/trachea) caused a dose- and time-dependent neutrophil accumulation in BAL fluid, the maximal effects of which were observed at 4 h post-SEB exposure (250 ng/trachea) [11].
  • CONCLUSION: The demonstration of serum BALP, in particular in non-jaundiced patients with high serum ALP, may indicate the presence of tumor in the bile duct [4].
  • Infants of smoker women have significantly lower umbilical cord blood BALP levels than those of infants from nonsmoker women [12].
  • Moreover, chronic hypoxia due to smoking may cause the suppression of bone matrix synthesis or placental synthesis as reflected by low OC and BALP levels in umbilical cord blood of infants from smoker women [12].

Associations of SLC27A5 with chemical compounds

  • COS-1 cells transiently overexpressing hVLCS-H2 activated the very-long-chain fatty acid lignocerate (C24:0) at a rate >1.5-fold higher than that of nontransfected cells (P < 0.002) [10].
  • Results: S-scores, DHEAS, and bioactive testosterone (BAT) were significantly (p < 0.05) lower and BAL and BAL/BAE were significantly higher among CBZ and PHT groups than among NC and LTG groups [7].
  • Conclusions: In comparison to LTG, enzyme inducing AEDs (CBZ, PHT) are associated with a more favorable neuroactive steroid balance (lower DHEAS and higher BAL/BAE) for seizure management, but at the expense of reduced serum bioavailable testosterone levels and sexual function [7].
  • The bile acid-CoA ligase has amino acid sequence similarity to several other polypeptides involved in the ATP-dependent linking of AMP or CoA to cyclic carboxylated compounds [13].
  • Transdermal estrogen treatment prevented the BALP increase, even if no reduction was observed; total ALP showed a similar behavior [14].

Regulatory relationships of SLC27A5


Other interactions of SLC27A5


Analytical, diagnostic and therapeutic context of SLC27A5


  1. Effect of chronic renal failure on bone turnover and bone alkaline phosphatase isoforms. Magnusson, P., Sharp, C.A., Magnusson, M., Risteli, J., Davie, M.W., Larsson, L. Kidney Int. (2001) [Pubmed]
  2. Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Hellings, P.W., Kasran, A., Liu, Z., Vandekerckhove, P., Wuyts, A., Overbergh, L., Mathieu, C., Ceuppens, J.L. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  3. Serum and BAL macrophage migration inhibitory factor levels in HIV infected Tanzanians with pulmonary tuberculosis or other lung diseases. Kibiki, G.S., van der Ven, A.J., Geurts-Moespot, A., Shao, J., Calandra, T., Sweep, F.C., Dolmans, W.M. Clin. Immunol. (2007) [Pubmed]
  4. Clinical value of biliary alkaline phosphatase in non-jaundiced cholangiocarcinoma. Bhudhisawasdi, V., Muisuk, K., Areejitranusorn, P., Kularbkaew, C., Khampitak, T., Saeseow, O.T., Wongkham, S. J. Cancer Res. Clin. Oncol. (2004) [Pubmed]
  5. The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase. Steinberg, S.J., Mihalik, S.J., Kim, D.G., Cuebas, D.A., Watkins, P.A. J. Biol. Chem. (2000) [Pubmed]
  6. Effect of stress on eotaxin and expression of adhesion molecules in a murine model of allergic airway inflammation. Joachim, R.A., Sagach, V., Quarcoo, D., Dinh, Q.T., Arck, P.C., Klapp, B.F. J. Neuroimmunol. (2007) [Pubmed]
  7. Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Dworetzky, B.A., Farina, E.L., Frye, C.A. Epilepsia (2006) [Pubmed]
  8. Short-term treatment with troglitazone decreases bone turnover in patients with type 2 diabetes mellitus. Okazaki, R., Miura, M., Toriumi, M., Taguchi, M., Hirota, Y., Fukumoto, S., Fujita, T., Tanaka, K., Takeuchi, A. Endocr. J. (1999) [Pubmed]
  9. Human very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport protein. Watkins, P.A., Pevsner, J., Steinberg, S.J. Prostaglandins Leukot. Essent. Fatty Acids (1999) [Pubmed]
  10. Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. Steinberg, S.J., Wang, S.J., McGuinness, M.C., Watkins, P.A. Mol. Genet. Metab. (1999) [Pubmed]
  11. Acute pulmonary inflammation induced by exposure of the airways to staphylococcal enterotoxin type B in rats. Desouza, I.A., Franco-Penteado, C.F., Camargo, E.A., Lima, C.S., Teixeira, S.A., Muscar??, M.N., De Nucci, G., Antunes, E. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  12. The effect of smoking on bone metabolism: maternal and cord blood bone marker levels. Colak, O., Alataş, O., Aydoğdu, S., Uslu, S. Clin. Biochem. (2002) [Pubmed]
  13. The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase. Mallonee, D.H., Adams, J.L., Hylemon, P.B. J. Bacteriol. (1992) [Pubmed]
  14. Clinical observations with a new specific assay for bone alkaline phosphatase: a cross-sectional study in osteoporotic and pagetic subjects and a longitudinal evaluation of the response to ovariectomy, estrogens, and bisphosphonates. Pedrazzoni, M., Alfano, F.S., Girasole, G., Giuliani, N., Fantuzzi, M., Gatti, C., Campanini, C., Passeri, M. Calcif. Tissue Int. (1996) [Pubmed]
  15. A refined radiation hybrid map of the telomeric region of bovine chromosome 18q25-q26 compared with human chromosome 19q13. Mömke, S., Kuiper, H., Spötter, A., Drögemüller, C., Distl, O. Anim. Genet. (2005) [Pubmed]
  16. Differences in sialic acid residues among bone alkaline phosphatase isoforms: a physical, biochemical, and immunological characterization. Magnusson, P., Farley, J.R. Calcif. Tissue Int. (2002) [Pubmed]
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