Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NUN9Q (6R,7S)-7-[[(2E)-2-(2-amino- 1,3-thiazol-4...

Synonyms: LS-132194, SN 401, BRN 4344904, A837565, I06-1102, ...

This record was replaced with 6857980.

Verbist, L. et al., Chattopadhyay, B. et al., Piot, P. et al., O'Callaghan, C.H. et al.

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Disease relevance of

The activity of GR-20263 against Pseudomonas aeruginosa (with minimal inhibitory concentrations of 2 and 8 micrograms/ml for 90 and 100% of the isolates, respectively) was similar to that of tobramycin, 2 times that of cefsulodin, 5 times that of piperacillin, and 10 times that of cefotaxime [1].
In vitro activity of ceftazidime (GR 20263) and other beta-lactam antibiotics against Haemophilus influenzae [2].

High impact information on

The in vitro activity of GR-20263, a new aminothiazolyl cephalosporin, was compared with the activities of other beta-lactam antibiotics by using 800 clinical bacterial isolates [1].
The beta-lactamase-producing strains were as susceptible to GR-20263 as the beta-lactamase-negative strains [1].

Chemical compound and disease context of

Ceftazidime (GR 20263), a new cephalosporin derivative with excellent activity against Pseudomonas and Enterobacteriaceae [3].

Analytical, diagnostic and therapeutic context of

GR 20263 is a new broad-spectrum injectable cephalosporin which is stable to most beta-lactamases [4].

References

GR-20263: a new aminothiazolyl cephalosporin with high activity against Pseudomonas and Enterobacteriaceae. Verbist, L., Verhaegen, J. Antimicrob. Agents Chemother. (1980) [Pubmed]
In vitro activity of ceftazidime (GR 20263) and other beta-lactam antibiotics against Haemophilus influenzae. Piot, P., Van Dyck, E., Colaert, J. Infection (1983) [Pubmed]
Ceftazidime (GR 20263), a new cephalosporin derivative with excellent activity against Pseudomonas and Enterobacteriaceae. Chattopadhyay, B., Hall, I., Curnow, S.R. J. Antimicrob. Chemother. (1981) [Pubmed]
GR 20263, a new broad-spectrum cephalosporin with anti-pseudomonal activity. O'Callaghan, C.H., Acred, P., Harper, P.B., Ryan, D.M., Kirby, S.M., Harding, S.M. Antimicrob. Agents Chemother. (1980) [Pubmed]

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