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Chemical Compound Review

Monaspor     sodium(6R,7S)-3-[(4- aminocarbonylpyridin...

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Disease relevance of (6R,7R)-3-[(4-carbamoylpyridin-1-yl)methyl]-8-oxo-7-[(2-phenyl-2-sulfo-acetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


High impact information on (6R,7R)-3-[(4-carbamoylpyridin-1-yl)methyl]-8-oxo-7-[(2-phenyl-2-sulfo-acetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


Chemical compound and disease context of (6R,7R)-3-[(4-carbamoylpyridin-1-yl)methyl]-8-oxo-7-[(2-phenyl-2-sulfo-acetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


Biological context of (6R,7R)-3-[(4-carbamoylpyridin-1-yl)methyl]-8-oxo-7-[(2-phenyl-2-sulfo-acetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

  • Cefsulodin pharmacokinetics in patients with various degrees of renal function [14].
  • The correlation found between the 2 renal clearances (r = 0.75; p less than 0.001) indicates that glomerular filtration rate has considerable influence on the renal elimination of cefsulodin [8].
  • Hydrolysis of cefsulodin was not detectable in assays used and enzyme binding (Ki) was poor, ensuring a very low physiological efficiency [15].
  • Cefsulodin was added to these synchronous cultures, which represented points in two to three rounds of the cell cycle [16].
  • Recent findings (F. García del Portillo, M. A. de Pedro, D. Joseleau-Petit, and R. D'Ari, J. Bacteriol. 171:4217-4221, 1989) have linked cefsulodin-induced lysis to septation during the first division cycle after a nutritional shift-up or chromosome replication realignment [16].

Anatomical context of (6R,7R)-3-[(4-carbamoylpyridin-1-yl)methyl]-8-oxo-7-[(2-phenyl-2-sulfo-acetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


Associations of (6R,7R)-3-[(4-carbamoylpyridin-1-yl)methyl]-8-oxo-7-[(2-phenyl-2-sulfo-acetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid with other chemical compounds


Gene context of (6R,7R)-3-[(4-carbamoylpyridin-1-yl)methyl]-8-oxo-7-[(2-phenyl-2-sulfo-acetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


Analytical, diagnostic and therapeutic context of (6R,7R)-3-[(4-carbamoylpyridin-1-yl)methyl]-8-oxo-7-[(2-phenyl-2-sulfo-acetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


  1. Cefsulodin kinetics in renal impairment. Gibson, T.P., Granneman, G.R., Kallal, J.E., Sennello, L.T. Clin. Pharmacol. Ther. (1982) [Pubmed]
  2. Cross-resistance to meropenem, cephems, and quinolones in Pseudomonas aeruginosa. Masuda, N., Ohya, S. Antimicrob. Agents Chemother. (1992) [Pubmed]
  3. Cefsulodin sodium therapy in cystic fibrosis patients. Cabezudo, I., Thompson, R.L., Selden, R.F., Guenthner, S.H., Wenzel, R.P. Antimicrob. Agents Chemother. (1984) [Pubmed]
  4. OXA-46, a new class D beta-lactamase of narrow substrate specificity encoded by a blaVIM-1-containing integron from a Pseudomonas aeruginosa clinical isolate. Giuliani, F., Docquier, J.D., Riccio, M.L., Pagani, L., Rossolini, G.M. Antimicrob. Agents Chemother. (2005) [Pubmed]
  5. Potent bacteriolytic activity of ritipenem associated with a characteristic profile of affinities for penicillin-binding proteins of Haemophilus influenzae. Inui, T., Oshida, T., Endo, T., Matsushita, T. Antimicrob. Agents Chemother. (1999) [Pubmed]
  6. Susceptibility to beta-lactam antibiotics of Pseudomonas aeruginosa overproducing penicillin-binding protein 3. Liao, X., Hancock, R.E. Antimicrob. Agents Chemother. (1997) [Pubmed]
  7. Target for bacteriostatic and bactericidal activities of beta-lactam antibiotics against Escherichia coli resides in different penicillin-binding proteins. Satta, G., Cornaglia, G., Mazzariol, A., Golini, G., Valisena, S., Fontana, R. Antimicrob. Agents Chemother. (1995) [Pubmed]
  8. Increased renal clearance of cefsulodin due to higher glomerular filtration rate in cystic fibrosis. Hedman, A., Alván, G., Strandvik, B., Arvidsson, A. Clinical pharmacokinetics. (1990) [Pubmed]
  9. Antibacterial activity and beta-lactamase stability of ceftazidime, an aminothiazolyl cephalosporin potentially active against Pseudomonas aeruginosa. Neu, H.C., Labthavikul, P. Antimicrob. Agents Chemother. (1982) [Pubmed]
  10. Comparative in vivo activities of cefsulodin, sulbenicillin, and gentamicin against Pseudomonas aeruginosa. Kondo, M., Tsuchiya, K. Antimicrob. Agents Chemother. (1978) [Pubmed]
  11. In vitro antibacterial activity of SM-1652, a new broad-spectrum cephalosporin with antipseudomonal activity. Fukasawa, M., Noguchi, H., Okuda, T., Komatsu, T., Yano, K. Antimicrob. Agents Chemother. (1983) [Pubmed]
  12. Pharmacokinetics of cefotiam and cefsulodin after simultaneous administration to patients with impaired renal function. Lecaillon, J.B., Rouan, M.C., Binswanger, U., Guibert, J., Schoeller, J.P. Antimicrob. Agents Chemother. (1984) [Pubmed]
  13. Bactericidal effect of polymorphonuclear neutrophils on antibiotic-induced filaments of gram-negative bacilli. Lorian, V., Atkinson, B. J. Infect. Dis. (1984) [Pubmed]
  14. Cefsulodin pharmacokinetics in patients with various degrees of renal function. Matzke, G.R., Keane, W.F. Antimicrob. Agents Chemother. (1983) [Pubmed]
  15. Kinetics and significance of the activity of the Sabath and Abrahams' beta-lactamase of Pseudomonas aeruginosa against cefotaxime and cefsulodin. Livermore, D.M. J. Antimicrob. Chemother. (1983) [Pubmed]
  16. Cell cycle-independent lysis of Escherichia coli by cefsulodin, an inhibitor of penicillin-binding proteins 1a and 1b. Jacoby, G.H., Young, K.D. J. Bacteriol. (1991) [Pubmed]
  17. Concentrations of cefamandole and cefsulodin in serum, heart valves, subcutaneous tissue, and muscle of patients undergoing open-heart surgery. Daschner, F.D., Metz, B., Spillner, G., Buzello, W., Schlosser, V. J. Infect. Dis. (1980) [Pubmed]
  18. N-acetyl-D-glucosamine medium improves recovery of Haemophilus influenzae from sputa of patients with cystic fibrosis. Möller, L.V., van Alphen, L., Grasselier, H., Dankert, J. J. Clin. Microbiol. (1993) [Pubmed]
  19. Cefsulodin in treatment of Pseudomonas urinary tract infection in patients with spinal cord injury. Comparison with aminoglycosides. Montgomerie, J.Z., Morrow, J.W., Canawati, H.N., Gilmore, D.S., Graham, I.E., Ibraham, M.Z. Urology (1986) [Pubmed]
  20. Cefsulodin levels in the human aqueous humor. Rubinstein, E., Avni, I., Tuizer, H., Treister, G., Blumenthal, M. Arch. Ophthalmol. (1985) [Pubmed]
  21. In vitro and in vivo antibacterial activities of carumonam (AMA-1080), a new N-sulfonated monocyclic beta-lactam antibiotic. Imada, A., Kondo, M., Okonogi, K., Yukishige, K., Kuno, M. Antimicrob. Agents Chemother. (1985) [Pubmed]
  22. Insensitivity of peptidoglycan biosynthetic reactions to beta-lactam antibiotics in a clinical isolate of Pseudomonas aeruginosa. Mirelman, D., Nuchamowitz, Y., Rubinstein, E. Antimicrob. Agents Chemother. (1981) [Pubmed]
  23. In vitro antibacterial activity and beta-lactamase stability of SCE-129, a new cephalosporin. Neu, H.C., Fu, K.P. Antimicrob. Agents Chemother. (1979) [Pubmed]
  24. Effects of urinary pH on renal interactions between probenecid and cefsulodin in rabbits. Dromer, F., Contrepois, A., Brion, N., Klein, C., Carbon, C. Antimicrob. Agents Chemother. (1985) [Pubmed]
  25. Fast lysis of Escherichia coli filament cells requires differentiation of potential division sites. de Pedro, M.A., Höltje, J.V., Schwarz, H. Microbiology (Reading, Engl.) (2002) [Pubmed]
  26. Interaction of FtsA and PBP3 proteins in the Escherichia coli septum. Tormo, A., Ayala, J.A., de Pedro, M.A., Aldea, M., Vicente, M. J. Bacteriol. (1986) [Pubmed]
  27. Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport? Susanto, M., Benet, L.Z. Pharm. Res. (2002) [Pubmed]
  28. Cefsulodin kinetics in healthy subjects after intramuscular and intravenous injection. Granneman, G.R., Sennello, L.T., Sonders, R.C., Wynne, B., Thomas, E.W. Clin. Pharmacol. Ther. (1982) [Pubmed]
  29. Bacteriological studies with cefsulodin (CGP 7174/E), the first antipseudomonal cephalosporin. Ullmann, U. J. Antimicrob. Chemother. (1979) [Pubmed]
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