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Chemical Compound Review:

Aba-nat (2S)-2-acetamido-3-[(3Z)-3- [(4...

Synonyms: ABA-L-Tyr, ABA-L-tyrosine, CHEBI:53741, AC1NUR3P, Azobenzenearsonate-N-acetyl-L-tyrosine, ...

Brunda, M.J. et al., Miyagawa, N. et al., Azuma, I. et al., Lawn, C.Y. et al., Amsden, A. et al.

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Disease relevance of Azobenzenearsonate-N-acetyl-L-tyrosine

The injection of secondary antigen into a mineral oil-induced inflammatory lesion did not induce delayed hypersensitivity, suggesting that specific reactivity to ABAT is a prerequisite for heterologous induction [1].
Hapten-specific T cell response to azobenzenearsonate-N-acetyl-L-tyrosine in the Lewis rat. I. Induction and suppression of delayed-type hypersensitivity and in vitro proliferative responses [2].

High impact information on Azobenzenearsonate-N-acetyl-L-tyrosine

Animals so treated developed delayed hypersensitivity to sheep red blood cells (SRBC) or Type II pneumococcal polysaccharide as secondary antigens, as measured by skin test reactivity and inhibition of macrophage migration, whereas ABAT unsensitized control groups did not [1].
Hapten-specific T-cell response to azobenzenearsonate-N-acetyl-L-tyrosine in the Lewis rat. IV. Rat dendritic cells present soluble and insoluble azobenzenearsonate conjugates to T cells [3].
Immunization of Lewis rats with azobenzenearsonate-N-acetyl-L-tyrosine (ABA-tyr) in complete Freund's adjuvant (CFA), produces a hapten-specific helper T cell response measured by an increase in plaque forming cells (PFC) against a different hapten [4].

Chemical compound and disease context of Azobenzenearsonate-N-acetyl-L-tyrosine

The adjuvant activity of 29 kinds of carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine was examined in guinea pigs [5].

References

Heterologous antigenic stimulation in induction of delayed hypersensitivity. Brunda, M.J., Raffel, S. J. Immunol. (1977) [Pubmed]
Hapten-specific T cell response to azobenzenearsonate-N-acetyl-L-tyrosine in the Lewis rat. I. Induction and suppression of delayed-type hypersensitivity and in vitro proliferative responses. Lawn, C.Y., Leskowitz, S. J. Immunol. (1980) [Pubmed]
Hapten-specific T-cell response to azobenzenearsonate-N-acetyl-L-tyrosine in the Lewis rat. IV. Rat dendritic cells present soluble and insoluble azobenzenearsonate conjugates to T cells. Amsden, A., Lawn, C.Y., Roy, S., Sunshine, G.H., Leskowitz, S. Cell. Immunol. (1985) [Pubmed]
Hapten-specific T cell response to azobenzene-arsonate-N-acetyl-L-tyrosine (ABA-tyr) in Lewis rats. II. Induction and suppression of ABA-specific helper cell activity for antibody production. Miyagawa, N., Lawn, C.Y., Leskowitz, S. Microbiol. Immunol. (1982) [Pubmed]
Adjuvant activity of carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine in guinea pigs. Azuma, I., Okumura, H., Saiki, I., Kiso, M., Hasegawa, A., Tanio, Y., Yamamura, Y. Infect. Immun. (1981) [Pubmed]

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