Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Benzacot N-[[4-(2-dimethylaminoethoxy) phenyl]methyl...

Synonyms: Stemetic, Tebamide, Trimazide, Tigan, Tribenzagan, ...

Hurley, J.D. et al., Shields, D. et al., Katzir, H. et al., Friedman, B.W. et al.

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Disease relevance of Nauseton

Fifty-five patients undergoing chemotherapy for various neoplastic processes were treated with trimethobenzamide or placebo to control nausea and vomiting [1].
A clinical trial of trimethobenzamide/diphenhydramine versus sumatriptan for acute migraines [2].
The effect of environmental temperature on the toxicity of cyclizine, trimethobenzamide, and Aspirin were studied in mice [3].

High impact information on Nauseton

In addition, KA/Tri rats showed that increased trimethobenzamide dosages were associated with decreased hilar, CA3c, CA3b, CA1, and subiculum neuron densities [4].

Chemical compound and disease context of Nauseton

Cooling decreased the toxicity of cyclizine and had no significant effect on that of trimethobenzamide or Aspirin [3].

Analytical, diagnostic and therapeutic context of Nauseton

Trimethobenzamide HCl in the treatment of nausea and vomiting associated with antineoplastic chemotherapy [1].

References

Trimethobenzamide HCl in the treatment of nausea and vomiting associated with antineoplastic chemotherapy. Hurley, J.D., Eshelman, F.N. Journal of clinical pharmacology. (1980) [Pubmed]
A clinical trial of trimethobenzamide/diphenhydramine versus sumatriptan for acute migraines. Friedman, B.W., Hochberg, M., Esses, D., Bijur, P.E., Corbo, J., Paternoster, J., Solorzano, C., Toosi, B., Lipton, R.B., Gallagher, E.J. Headache. (2006) [Pubmed]
Stress modification of the toxicity of antimotion sickness drugs and aspirin. Shields, D., Marra, C., Goodwin, A., Vernikos-Danellis, J. Pharmacology (1975) [Pubmed]
Effect of theophylline and trimethobenzamide when given during kainate-induced status epilepticus: an improved histopathologic rat model of human hippocampal sclerosis. Katzir, H., Mendoza, D., Mathern, G.W. Epilepsia (2000) [Pubmed]

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