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MeSH Review

Neoplastic Processes

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Disease relevance of Neoplastic Processes


High impact information on Neoplastic Processes

  • In its wild-type form, the protein p53 can interfere with neoplastic processes [6].
  • In humans, mutations in T-box genes are responsible for developmental dysmorphic syndromes, and several T-box genes have been implicated in neoplastic processes [7].
  • These contrasting immunological phenomena are examined as contributing factors responsible for the enhancement by this virus of asparaginase (EC; L-asparagine amidolydrolase) therapy against leukemia in mice, and for the alteration of the susceptibility of mice to various neoplastic processes [8].
  • Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) regulate the degradation of extracellular matrix components and play important roles in the progression of select neoplastic processes [9].
  • However, despite the large body of genetic and biological evidence suggesting the importance of RET in development and neoplastic processes, the signal transduction mechanisms of RET remain unknown [10].

Chemical compound and disease context of Neoplastic Processes


Biological context of Neoplastic Processes


Anatomical context of Neoplastic Processes


Gene context of Neoplastic Processes

  • This is the first demonstration of somatic beta-catenin mutations in a locally invasive, but non metastatic lesion composed of spindle cells, illustrating the importance of beta-catenin stabilization in a variety of cell types and neoplastic processes [26].
  • Finally, the role of DC-SIGN in pathology, particularly in infective and neoplastic processes, is discussed, followed by speculation about likely future developments in this field [27].
  • Transforming growth factor-beta 1 (TGF-beta1), a multifunctional cytokine secreted by various cell types has been implicated in diverse physiologic and pathophysiologic functions, including immunological, inflammatory, and neoplastic processes [28].
  • Because differential splicing produces multiple isoforms with potentially different functions, Ikaros provides a unique model to study how post-transcriptional mechanisms may be involved in neoplastic processes [29].
  • These data further support the notion that BKV TAg can affect cellular growth control mechanisms and may in fact be involved in neoplastic processes [30].

Analytical, diagnostic and therapeutic context of Neoplastic Processes


  1. The leukocyte semaphorin CD100 is expressed in most T-cell, but few B-cell, non-Hodgkin's lymphomas. Dorfman, D.M., Shahsafaei, A., Nadler, L.M., Freeman, G.J. Am. J. Pathol. (1998) [Pubmed]
  2. The expression of Ep-CAM (17-1A) in squamous cell cancers of the lung. Piyathilake, C.J., Frost, A.R., Weiss, H., Manne, U., Heimburger, D.C., Grizzle, W.E. Hum. Pathol. (2000) [Pubmed]
  3. CXCR3 expression in human central nervous system diseases. Goldberg, S.H., van der Meer, P., Hesselgesser, J., Jaffer, S., Kolson, D.L., Albright, A.V., González-Scarano, F., Lavi, E. Neuropathol. Appl. Neurobiol. (2001) [Pubmed]
  4. Expression of Po66-CBP, a galectin-8, in different types of primary and secondary broncho-pulmonary tumors. Henno, S., Brichory, F., Langanay, T., Desrues, B., Bidon, N., Delaval, P., Ramee, M.P., Dazord, L., Caulet-Maugendre, S. Oncol. Rep. (2002) [Pubmed]
  5. 17 beta-estradiol-regulated expression of protein tyrosine phosphatase gamma gene in cultured human normal breast and breast cancer cells. Zheng, J., Kulp, S.K., Zhang, Y., Sugimoto, Y., Dayton, M.A., Govindan, M.V., Brueggemeier, R.W., Lin, Y.C. Anticancer Res. (2000) [Pubmed]
  6. Different tumor-derived p53 mutants exhibit distinct biological activities. Halevy, O., Michalovitz, D., Oren, M. Science (1990) [Pubmed]
  7. T-box genes in vertebrate development. Naiche, L.A., Harrelson, Z., Kelly, R.G., Papaioannou, V.E. Annu. Rev. Genet. (2005) [Pubmed]
  8. Antibody-producing cells: virus-induced alteration of response to antigen. Riley, V., Braun, W., Ishizuka, M., Spackman, D. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  9. Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis. Kong, Y., Poon, R., Nadesan, P., Di Muccio, T., Fodde, R., Khokha, R., Alman, B.A. Cancer Res. (2004) [Pubmed]
  10. Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities. Liu, X., Vega, Q.C., Decker, R.A., Pandey, A., Worby, C.A., Dixon, J.E. J. Biol. Chem. (1996) [Pubmed]
  11. The effect of an aromatase inhibitor, 4-hydroxy-4-androstene-3,17-dione, on estrogen-dependent processes in reproduction and breast cancer. Brodie, A.M., Schwarzel, W.C., Shaikh, A.A., Brodie, H.J. Endocrinology (1977) [Pubmed]
  12. A 50 Hz magnetic field blocks melatonin-induced enhancement of junctional transfer in normal C3H/10T1/2 cells. Ubeda, A., Trillo, M.A., House, D.E., Blackman, C.F. Carcinogenesis (1995) [Pubmed]
  13. Nicorandil and idiopathic anal ulceration. Katory, M., Davies, B., Kelty, C., Arasaradnam, R., Skinner, P., Brown, S., Bagley, J., Shorthouse, A.J., Hunt, L.M., Slater, R. Dis. Colon Rectum (2005) [Pubmed]
  14. The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. Llor, X., Pons, E., Roca, A., Alvarez, M., Mañé, J., Fernández-Bañares, F., Gassull, M.A. Clinical nutrition (Edinburgh, Scotland) (2003) [Pubmed]
  15. Tenascin-C is highly expressed in respiratory distress syndrome and bronchopulmonary dysplasia. Kaarteenaho-Wiik, R., Kinnula, V.L., Herva, R., Soini, Y., Pöllänen, R., Pääkkö, P. J. Histochem. Cytochem. (2002) [Pubmed]
  16. Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif. Ragimov, N., Krauskopf, A., Navot, N., Rotter, V., Oren, M., Aloni, Y. Oncogene (1993) [Pubmed]
  17. Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. Cheon, S.S., Nadesan, P., Poon, R., Alman, B.A. Exp. Cell Res. (2004) [Pubmed]
  18. S100A6 protein expression is different in Spitz nevi and melanomas. Ribé, A., McNutt, N.S. Mod. Pathol. (2003) [Pubmed]
  19. Mechanisms and effectors of MIF-dependent promotion of tumourigenesis. Mitchell, R.A. Cell. Signal. (2004) [Pubmed]
  20. Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Portella, G., Cumming, S.A., Liddell, J., Cui, W., Ireland, H., Akhurst, R.J., Balmain, A. Cell Growth Differ. (1998) [Pubmed]
  21. Protein-binding elements in the promoter region of the mouse p53 gene. Ginsberg, D., Oren, M., Yaniv, M., Piette, J. Oncogene (1990) [Pubmed]
  22. Immunohistochemical evaluation of neoplasms in bone marrow biopsies using monoclonal antibodies reactive in paraffin-embedded tissue. Kubic, V.L., Brunning, R.D. Mod. Pathol. (1989) [Pubmed]
  23. Contrast enhancement in spinal MR imaging. Breger, R.K., Williams, A.L., Daniels, D.L., Czervionke, L.F., Mark, L.P., Haughton, V.M., Papke, R.A., Coffer, M. AJR. American journal of roentgenology. (1989) [Pubmed]
  24. The role of macrophages in angiogenesis. Comparison between HIV+ and HIV- populations with anal dysplasia and anal cancer. Mullerat, J., Perrett, C.W., Deroide, F., Winslet, M.C., Bofill, M., Poulters, L.W. Anticancer Res. (2005) [Pubmed]
  25. Effects of female sex steroids on concanavalin A-mediated agglutination of hepatocytes from nonregenerating and regenerating rat liver and hepatic tumor marker enzymes. Annapurna, V.V., Mukundan, M.A., Sesikeran, B., Bamji, M.S. Biochem. Med. Metab. Biol. (1987) [Pubmed]
  26. Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor). Tejpar, S., Nollet, F., Li, C., Wunder, J.S., Michils, G., dal Cin, P., Van Cutsem, E., Bapat, B., van Roy, F., Cassiman, J.J., Alman, B.A. Oncogene (1999) [Pubmed]
  27. DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC-SIGN-related (DC-SIGNR): friend or foe? Soilleux, E.J. Clin. Sci. (2003) [Pubmed]
  28. Suppression of macrophage function in AK-5 tumor transplanted animals: role of TGF-beta1. Mitra, R., Khar, A. Immunol. Lett. (2004) [Pubmed]
  29. Ikaros gene expression and leukemia. Tonnelle, C., Calmels, B., Maroc, C., Gabert, J., Chabannon, C. Leuk. Lymphoma (2002) [Pubmed]
  30. BK virus large T antigen: interactions with the retinoblastoma family of tumor suppressor proteins and effects on cellular growth control. Harris, K.F., Christensen, J.B., Imperiale, M.J. J. Virol. (1996) [Pubmed]
  31. Nuclear medicine techniques in the evaluation of pulmonary neoplasia. Waxman, A.D. Journal of thoracic imaging. (1987) [Pubmed]
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