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Chemical Compound Review:

dihydrotachysterol (1S,3E,4S)-3-[(2E)-2- [(3aR,7aR)-1-[(E,2S...

Synonyms: AC1NWALO, HMS502L11, IDI1_000869

Qaw, F. et al., Braun, J.J. et al., Puliyanda, D.P. et al., Miller, S. et al., Rosenblum, I.Y. et al.

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Disease relevance of dihydrotachysterol

Calciphylaxis is a local tissue calcific reaction at the site of an injection of challenger substance given a critical time period after the oral administration of a sensitizer substance such as dihydrotachysterol (DHT), vitamin D or parathormone [1].
The hepatoma cell line 25-hydroxylated DHT and no feed-back inhibition was observed [2].
The response of serum 1,25-dihydroxycholecalciferol (1,25-OH2CC) concentration to the administration of parathyroid extract (PTE) was studied in a patient with pseudohypoparathyroidism (PHP) type 1, 3 days after withdrawal of dihydrotachysterol (DHT) treatment [3].
The metabolism of dihydrotachysterol (DHT), a hydrogenated analogue of vitamin D, has been studied in vivo using man and rat and in vitro using the perfused rat kidney, and hepatoma (3B) and osteosarcoma (UMR-106) cell lines [2].
A single oral dose of dihydrotachysterol (DHT) administered to rats induced myocardial and vascular degeneration, focal myocarditis and vasculitis, and myocardial and vascular mineralization [4].

High impact information on dihydrotachysterol

DHT does not appear to elicit general proteolysis, however, in addition to AQP2 degradation, DHT treatment also diminished micro-calpain and calpastatin expression although whether these changes contributed to the AQP2 instability remains unclear [5].

References

Cutaneous calciphylactic reactions in the mouse and the rat and the effects of diphosphonates on the reaction in the rat. Miller, S., Vernon-Roberts, E., McClure, J. J. Pathol. (1984) [Pubmed]
The metabolism of dihydrotachysterols: renal side chain and non-renal nuclear hydroxylations in vivo and in vitro. Qaw, F., Schroeder, N.J., Calverley, M.J., Trafford, D.J., Makin, H.L., Jones, G. J. Steroid Biochem. Mol. Biol. (1992) [Pubmed]
Lack of response of 1,25-dihydroxycholecalciferol to exogenous parathyroid hormone in a patient with treated pseudohypoparathyroidism. Braun, J.J., Birkenhäger, J.C., Visser, T.J., Juttmann, J.R. Clin. Endocrinol. (Oxf) (1981) [Pubmed]
The effects of various diphosphonates on a rat model of cardiac calciphylaxis. Rosenblum, I.Y., Black, H.E., Ferrell, J.F. Calcified tissue research. (1977) [Pubmed]
Calpain-mediated AQP2 proteolysis in inner medullary collecting duct. Puliyanda, D.P., Ward, D.T., Baum, M.A., Hammond, T.G., Harris, H.W. Biochem. Biophys. Res. Commun. (2003) [Pubmed]

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