Gene Review:
CAST - calpastatin
Homo sapiens
Synonyms:
Calpain inhibitor, Calpastatin, Sperm BS-17 component
- Detection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis sera. Després, N., Talbot, G., Plouffe, B., Boire, G., Ménard, H.A. J. Clin. Invest. (1995)
- Functional properties of recombinant calpain I and of mutants lacking domains III and IV of the catalytic subunit. Vilei, E.M., Calderara, S., Anagli, J., Berardi, S., Hitomi, K., Maki, M., Carafoli, E. J. Biol. Chem. (1997)
- Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis. Altznauer, F., Conus, S., Cavalli, A., Folkers, G., Simon, H.U. J. Biol. Chem. (2004)
- Expression of a calpastatin transgene slows muscle wasting and obviates changes in myosin isoform expression during murine muscle disuse. Tidball, J.G., Spencer, M.J. J. Physiol. (Lond.) (2002)
- Molecular cloning and characterization of functional domains of a human testis-specific isoform of calpastatin. Li, S., Liang, Z.G., Wang, G.Y., Yavetz, B., Kim, E.D., Goldberg, E. Biol. Reprod. (2000)
- Mutation analysis of the calpastatin gene (CAST) in patients with Alzheimer's disease. Nakayama, J., Yoshizawa, T., Yamamoto, N., Arinami, T. Neurosci. Lett. (2002)
- The calpain system. Goll, D.E., Thompson, V.F., Li, H., Wei, W., Cong, J. Physiol. Rev. (2003)
- Cytoskeletal regulation couples LFA-1 conformational changes to receptor lateral mobility and clustering. Cairo, C.W., Mirchev, R., Golan, D.E. Immunity (2006)
- WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP). de la Fuente, M.A., Sasahara, Y., Calamito, M., Antón, I.M., Elkhal, A., Gallego, M.D., Suresh, K., Siminovitch, K., Ochs, H.D., Anderson, K.C., Rosen, F.S., Geha, R.S., Ramesh, N. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Calpain inhibitor II induces caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin's lymphoma cells as well as some solid tumor cells. Zhu, D.M., Uckun, F.M. Clin. Cancer Res. (2000)
- Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors. Molla, A., Hellen, C.U., Wimmer, E. J. Virol. (1993)
- Biochemical interaction between Tamm-Horsfall glycoprotein and Ig light chains in the pathogenesis of cast nephropathy. Huang, Z.Q., Sanders, P.W. Lab. Invest. (1995)
- Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester. Oka, T., Walkup, R.D., Tamada, Y., Nakajima, E., Tochigi, A., Shearer, T.R., Azuma, M. Neuroscience (2006)
- Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system. Grynspan, F., Griffin, W.B., Mohan, P.S., Shea, T.B., Nixon, R.A. J. Neurosci. Res. (1997)
- Characterization of a functional domain of human calpastatin. Uemori, T., Shimojo, T., Asada, K., Asano, T., Kimizuka, F., Kato, I., Maki, M., Hatanaka, M., Murachi, T., Hanzawa, H. Biochem. Biophys. Res. Commun. (1990)
- Autoantibodies to calpastatin (an endogenous inhibitor for calcium-dependent neutral protease, calpain) in systemic rheumatic diseases. Mimori, T., Suganuma, K., Tanami, Y., Nojima, T., Matsumura, M., Fujii, T., Yoshizawa, T., Suzuki, K., Akizuki, M. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Increase in ultraviolet sensitivity by overexpression of calpastatin in ultraviolet-resistant UVr-1 cells derived from ultraviolet-sensitive human RSa cells. Hiwasa, T., Arase, Y., Kikuno, K., Hasegawa, R., Sugaya, S., Kita, K., Saido, T., Yamamori, H., Maki, M., Suzuki, N. Cell Death Differ. (2000)
- Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells. Adachi, Y., Ishida-Takahashi, A., Takahashi, C., Takano, E., Murachi, T., Hatanaka, M. J. Biol. Chem. (1991)
- Calpain inhibition decreases the growth rate of mammalian cell colonies. Xu, Y., Mellgren, R.L. J. Biol. Chem. (2002)
- Molecular diversity in amino-terminal domains of human calpastatin by exon skipping. Lee, W.J., Ma, H., Takano, E., Yang, H.Q., Hatanaka, M., Maki, M. J. Biol. Chem. (1992)
- Improved posthypoxic recovery of synaptic transmission in gerbil neocortical slices treated with a calpain inhibitor. Hiramatsu, K., Kassell, N.F., Lee, K.S. Stroke (1993)
- Calpastatin in erythrocytes of young and old individuals. Schwarz-Benmeir, N., Glaser, T., Barnoy, S., Kosower, N.S. Biochem. J. (1994)
- Differential sensitivity of interleukin-1 alpha and -beta precursor proteins to cleavage by calpain, a calcium-dependent protease. Kavita, U., Mizel, S.B. J. Biol. Chem. (1995)
- AlphaPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Rosenberger, G., Gal, A., Kutsche, K. J. Biol. Chem. (2005)
- Association of the calpain/calpastatin network with subcellular organelles. Hood, J.L., Logan, B.B., Sinai, A.P., Brooks, W.H., Roszman, T.L. Biochem. Biophys. Res. Commun. (2003)
- Requirement of different subdomains of calpastatin for calpain inhibition and for binding to calmodulin-like domains. Ma, H., Yang, H.Q., Takano, E., Lee, W.J., Hatanaka, M., Maki, M. J. Biochem. (1993)
- Cleavage of nonmuscle myosin heavy chain-A during apoptosis in human Jurkat T cells. Kato, M., Fukuda, H., Nonaka, T., Imajoh-Ohmi, S. J. Biochem. (2005)
- Calpain inhibitor causes accumulation of ubiquitinated P-glycoprotein at the cell surface: possible role of calpain in P-glycoprotein turnover. Ohkawa, K., Asakura, T., Takada, K., Sawai, T., Hashizume, Y., Okawa, Y., Yanaihara, N. Int. J. Oncol. (1999)
- Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis. Ishikawa, H., Nakagawa, Y., Shimizu, K., Nishihara, H., Matsusue, Y., Nakamura, T. Biochem. Biophys. Res. Commun. (1999)
- Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus. Miralem, T., Avraham, H.K. Mol. Cell. Biol. (2003)
- Inhibition of p21/Waf1/Cip1/Sdi1 expression by hepatitis C virus core protein. Yoshida, I., Oka, K., Hidajat, R., Nagano-Fujii, M., Ishido, S., Hotta, H. Microbiol. Immunol. (2001)
- Mu-calpain activation in beta-lapachone-mediated apoptosis. Tagliarino, C., Pink, J.J., Reinicke, K.E., Simmers, S.M., Wuerzberger-Davis, S.M., Boothman, D.A. Cancer Biol. Ther. (2003)
- Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway. Sawhney, R.S., Cookson, M.M., Omar, Y., Hauser, J., Brattain, M.G. J. Biol. Chem. (2006)
- Calcium-activated neutral proteinase (CANP; calpain) activity in Schwann cells: immunofluorescence localization and compartmentation of mu- and mCANP. Banik, N.L., DeVries, G.H., Neuberger, T., Russell, T., Chakrabarti, A.K., Hogan, E.L. J. Neurosci. Res. (1991)
- A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Shields, D.C., Schaecher, K.E., Saido, T.C., Banik, N.L. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation. Han, Y., Weinman, S., Boldogh, I., Walker, R.K., Brasier, A.R. J. Biol. Chem. (1999)
- Identification of mu-, m-calpains and calpastatin and capture of mu-calpain activation in endothelial cells. Fujitani, K., Kambayashi, J., Sakon, M., Ohmi, S.I., Kawashima, S., Yukawa, M., Yano, Y., Miyoshi, H., Ikeda, M., Shinoki, N., Monden, M. J. Cell. Biochem. (1997)