Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

inosine 9-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: Inosinum, Inosina, Oxiamin, Atorel, Inosie, ...

Ishiguro, K. et al., Grune, T. et al., Möllhoff, T. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of inosine

Apart from the delay (7 to 9-fold), hypothermia also reversed the ratio between ADO and INO when compared to normothermia, suggesting a profound effect of temperature on the nucleoside transporter [1].

High impact information on inosine

Since hypoxanthine (Hyp) and inosine (Ino) have been identified as putative endogenous ligands for high affinity benzodiazepine receptors in brain tissue, the potential involvement of benzodiazepine receptors in the differentiation of HL-60 cells by the purines was investigated [2].
The separation of adenine (Ade), adenosine (Ado), guanine (Gua), guanosine (Guo), hypoxanthine (Hyp), inosine (Ino), xanthine (Xan) and uric acid (UA) was optimized with respect to pH, temperature, applied potential and hydrodynamic injection time [3].

References

Effects of hypothermic ischemia on purine catabolism in canine, primate, and human myocardium. Möllhoff, T., Sukehiro, S., Hendrickx, M., Van Belle, H., Flameng, W. The Thoracic and cardiovascular surgeon. (1991) [Pubmed]
The role of benzodiazepine receptors in the induction of differentiation of HL-60 leukemia cells by benzodiazepines and purines. Ishiguro, K., Taft, W.C., DeLorenzo, R.J., Sartorelli, A.C. J. Cell. Physiol. (1987) [Pubmed]
Optimized separation of purine bases and nucleosides in human cord plasma by capillary zone electrophoresis. Grune, T., Ross, G.A., Schmidt, H., Siems, W., Perrett, D. J. Chromatogr. (1993) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share