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Chemical Compound Review:

AG-H-27073 propane-1,2-dithiol

Synonyms: ACMC-209plj, ANW-37445, NSC-72085, LS-3061, NSC72085, ...

Takahashi, Y. et al., Takahashi, Y. et al., Lund, M.E. et al., Burckhardt, G. et al.

Burckhardt, Wolff, Bahn,

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Disease relevance of NSC72085

In addition, the comparative effects of 2,3-dimercaptopropane sulfonate (DMPS), N-(2-mercapto-2-methylpropanoyl)-L-cysteine (bucillamine), captopril, and tiopronin at various dose levels (1.2, 0.4 or 0.2 mmol/kg) on the distribution and renal toxicity of gold were studied [1].

High impact information on NSC72085

Anionic neurotransmitter metabolites and the heavy-metal chelator, 2,3-dimercaptopropane sulfonate, interacted with the rabbit renal OAT1, which is expressed in kidneys and the retina [2].
A case of acute methylmercury ingestion was treated sequentially with oral D-penicillamine, hemodialysis during N-acetylcysteine (NAC) infusion, and 2,3-dimercaptopropane sulfonate (DMPS) an experimental oral agent [3].

Chemical compound and disease context of NSC72085

The effects of the repeated administration of D-penicillamine, 2,3-dimercaptosuccinic acid, 2,3-dimercaptopropane sulphonate, and N-(2-mercapto-2-methylpropanoyl)-L-cysteine 24 h after gold sodium thiomalate (AuTM) injection on the distribution, excretion, and renal toxicity of gold in rats were investigated [4].

References

Comparative effects of chelating agents on distribution, excretion, and renal toxicity of gold sodium thiomalate in rats. Takahashi, Y., Funakoshi, T., Shimada, H., Kojima, S. Toxicology (1994) [Pubmed]
Molecular characterization of the renal organic anion transporter 1. Burckhardt, G., Wolff, N.A., Bahn, A. Cell Biochem. Biophys. (2002) [Pubmed]
Treatment of acute methylmercury ingestion by hemodialysis with N-acetylcysteine (Mucomyst) infusion and 2,3-dimercaptopropane sulfonate. Lund, M.E., Banner, W., Clarkson, T.W., Berlin, M. J. Toxicol. Clin. Toxicol. (1984) [Pubmed]
Effect of repeated administration of chelating agents on distribution, excretion, and renal toxicity of gold sodium thiomalate in rats. Takahashi, Y., Funakoshi, T., Shimada, H., Kiyozumi, M., Kojima, S. Res. Commun. Chem. Pathol. Pharmacol. (1992) [Pubmed]

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