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Chemical Compound Review

Succimer     2,3-bis-sulfanylbutanedioic acid

Synonyms: Suximer, DMSA, CHEMBL28721, D7881_ALDRICH, AG-E-71453, ...
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Disease relevance of Dimercaptosuccinic acid


Psychiatry related information on Dimercaptosuccinic acid


High impact information on Dimercaptosuccinic acid


Chemical compound and disease context of Dimercaptosuccinic acid


Biological context of Dimercaptosuccinic acid

  • Administration of DMSA attenuated the oxidative stress and apoptosis in addition to having strong chelating and lead-removing capacity [20].
  • DMSA treatment ameliorated the mean blood pressure rise in the Dahl SS rats (141 +/- 5 vs. 120 +/- 4 mm Hg at 6 weeks, P < 0.001) [21].
  • The aim of this study was to investigate the variability in the interpretation of DMSA scans by pediatric nuclear medicine physicians in this clinical setting [22].
  • These data demonstrate that commonly encountered changes in acid-base balance and hydration will significantly alter the biologic distribution of Tc-99m DMSA [6].
  • Delayed scanning with DMSA: a simple index of relative renal plasma flow [23].

Anatomical context of Dimercaptosuccinic acid


Associations of Dimercaptosuccinic acid with other chemical compounds


Gene context of Dimercaptosuccinic acid


Analytical, diagnostic and therapeutic context of Dimercaptosuccinic acid


  1. Treatment of lead poisoning by 2,3-dimercaptosuccinic acid. Friedheim, E., Graziano, J.H., Popovac, D., Dragovic, D., Kaul, B. Lancet (1978) [Pubmed]
  2. Color and power Doppler sonography versus DMSA scintigraphy in acute pyelonephritis and in prediction of renal scarring. Hitzel, A., Liard, A., Véra, P., Manrique, A., Ménard, J.F., Dacher, J.N. J. Nucl. Med. (2002) [Pubmed]
  3. Technetium-99m (v) dimercaptosuccinic acid uptake in patients with head and neck squamous carcinoma: experience in imaging. Watkinson, J.C., Lazarus, C.R., Mistry, R., Shaheen, O.H., Maisey, M.N., Clarke, S.E. J. Nucl. Med. (1989) [Pubmed]
  4. Technetium-99m (V) DMSA uptake in amyloidosis. Ohta, H., Endo, K., Kanoh, T., Konishi, J., Kotoura, H. J. Nucl. Med. (1989) [Pubmed]
  5. Complete and partial ureteral obstruction: evaluation of renal effects with P-31 MR spectroscopy and Tc-DMSA scintigraphy. Vigneron, D.B., Tzika, A.A., Hricak, H., Price, D.C., Bretan, P., Aboseif, S., Müller, S., James, T.L. Radiology. (1988) [Pubmed]
  6. Tc-99m DMSA renal uptake: influence of biochemical and physiologic factors. Yee, C.A., Lee, H.B., Blaufox, M.D. J. Nucl. Med. (1981) [Pubmed]
  7. Reliability of DMSA for the diagnosis of renal parenchymal abnormality in children. Craig, J.C., Irwig, L., Ford, M., Willis, N.S., Howman-Giles, R.B., Uren, R.F., Rossleigh, M.A., Grunewald, S. European journal of nuclear medicine. (2000) [Pubmed]
  8. Porphyrinuria in childhood autistic disorder: implications for environmental toxicity. Nataf, R., Skorupka, C., Amet, L., Lam, A., Springbett, A., Lathe, R. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  9. DMSA chelation during co-exposure to lead: increased locomotor activity in lead-exposed mice but not controls. Stewart, P.W., Burright, R.G., Donovick, P.J. Physiol. Behav. (1995) [Pubmed]
  10. meso-2,3-Dimercaptosuccinic acid: chemical, pharmacological and toxicological properties of an orally effective metal chelating agent. Aposhian, H.V., Aposhian, M.M. Annu. Rev. Pharmacol. Toxicol. (1990) [Pubmed]
  11. Are younger children at highest risk of renal sequelae after pyelonephritis? Benador, D., Benador, N., Slosman, D., Mermillod, B., Girardin, E. Lancet (1997) [Pubmed]
  12. Screening of newborn babies for familial ureteric reflux. Scott, J.E., Swallow, V., Coulthard, M.G., Lambert, H.J., Lee, R.E. Lancet (1997) [Pubmed]
  13. Interactions of dithiols with p-aminophenyldichloroarsine and nicotinic acetylcholine receptors. Dou, Y.M., McHugh, T., Lane, W.V., Rossant, C.J., Loring, R.H. J. Biol. Chem. (1994) [Pubmed]
  14. Chelators as antidotes of metal toxicity: therapeutic and experimental aspects. Blanusa, M., Varnai, V.M., Piasek, M., Kostial, K. Current medicinal chemistry. (2005) [Pubmed]
  15. Pentavalent technetium-99m-DMSA uptake in a patient having multiple myeloma without amyloidosis. Ohnishi, T., Noguchi, S., Murakami, N., Tajiri, J., Morita, M., Tamaru, M., Hoshi, H., Watanabe, K. J. Nucl. Med. (1991) [Pubmed]
  16. Diagnostic use of angiotensin converting enzyme inhibitors in radioisotope evaluation of unilateral renal artery stenosis. Kremer Hovinga, T.K., de Jong, P.E., Piers, D.A., Beekhuis, H., van der Hem, G.K., de Zeeuw, D. J. Nucl. Med. (1989) [Pubmed]
  17. Pentavalent technetium-99m-dimercaptosuccinic acid scintigraphy in renal osteodystrophy. Higuchi, T., Hirano, T., Inoue, T., Aoki, J., Ueki, K., Wakamatsu, R., Yano, S., Naruse, T., Endo, K. J. Nucl. Med. (1998) [Pubmed]
  18. The value of quantitative 99M technetium dimercaptosuccinic acid renal scintigraphy for predicting postoperative renal insufficiency in patients undergoing nephrectomy. Mullerad, M., Kastin, A., Issaq, E., Moskovitz, B., Groshar, D., Nativ, O. J. Urol. (2003) [Pubmed]
  19. Determination and metabolism of dithiol chelating agents. IV. Urinary excretion of meso-2,3-dimercaptosuccinic acid and mercaptosuccinic acid in rabbits given meso-2,3-dimercaptosuccinic acid. Maiorino, R.M., Aposhian, H.V. Biochem. Pharmacol. (1989) [Pubmed]
  20. The effects of meso-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus. Zhang, J., Wang, X.F., Lu, Z.B., Liu, N.Q., Zhao, B.L. Free Radic. Biol. Med. (2004) [Pubmed]
  21. Effect of 2,3-dimercaptosuccinic acid on nephrosclerosis in the Dahl rat. I. Role of reactive oxygen species. Gonick, H.C., Cohen, A.H., Ren, Q., Saldanha, L.F., Khalil-Manesh, F., Anzalone, J., Sun, Y.Y. Kidney Int. (1996) [Pubmed]
  22. Variability in the interpretation of dimercaptosuccinic acid scintigraphy after urinary tract infection in children. Craig, J.C., Irwig, L.M., Howman-Giles, R.B., Uren, R.F., Bernard, E.J., Knight, J.F., Sureshkumar, P., Roy, L.P. J. Nucl. Med. (1998) [Pubmed]
  23. Delayed scanning with DMSA: a simple index of relative renal plasma flow. Taylor, A. Radiology. (1980) [Pubmed]
  24. A new imaging agent for medullary carcinoma of the thyroid. Ohta, H., Yamamoto, K., Endo, K., Mori, T., Hamanaka, D., Shimazu, A., Ikekubo, K., Makimoto, K., Iida, Y., Konishi, J. J. Nucl. Med. (1984) [Pubmed]
  25. Scintigraphic evaluation of tenosynovial giant-cell tumor using technetium-99m(V)-dimercaptosuccinic acid. Kobayashi, H., Sakahara, H., Hosono, M., Shirato, M., Konishi, J., Kotoura, Y., Yamamuro, T., Endo, K. J. Nucl. Med. (1993) [Pubmed]
  26. Pharmacokinetics of meso-2,3-dimercaptosuccinic acid in patients with lead poisoning and in healthy adults. Dart, R.C., Hurlbut, K.M., Maiorino, R.M., Mayersohn, M., Aposhian, H.V., Hassen, L.V. J. Pediatr. (1994) [Pubmed]
  27. Transport of organic anions across the basolateral membrane of proximal tubule cells. Burckhardt, B.C., Burckhardt, G. Rev. Physiol. Biochem. Pharmacol. (2003) [Pubmed]
  28. Technetium-99m dimercaptosuccinic acid scintigraphy studies of renal cortical scarring and renal length. Rossleigh, M.A., Farnsworth, R.H., Leighton, D.M., Yong, J.L., Rose, M., Christian, C.L. J. Nucl. Med. (1998) [Pubmed]
  29. Use of 99mTc (V) DMSA scintigraphy in the detection and localization of intestinal inflammation: comparison of findings and colonoscopy and biopsy. Lee, B.F., Chiu, N.T., Wu, D.C., Tsai, K.B., Liu, G.C., Yu, H.S., Wang, S.T. Radiology. (2001) [Pubmed]
  30. Soft-tissue tumors: diagnosis with Tc-99m (V) dimercaptosuccinic acid scintigraphy. Kobayashi, H., Sakahara, H., Hosono, M., Shirato, M., Endo, K., Kotoura, Y., Yamamuro, T., Konishi, J. Radiology. (1994) [Pubmed]
  31. Ifosfamide-induced alteration of technetium-99m-DMSA renal parenchymal imaging. Morrison, S.C., O'Donnell, J.K. J. Nucl. Med. (1997) [Pubmed]
  32. Urinary levels of interleukin-6 and interleukin-8 in children with urinary tract infections to age 2. Krzemień, G., Roszkowska-Blaim, M., Kostro, I., Szmigielska, A., Karpińska, M., Sieniawska, M., Bartłomiejczyk, I., Paczek, L., Toth, K. Med. Sci. Monit. (2004) [Pubmed]
  33. Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication. Flora, S.J., Pande, M., Mehta, A. Chem. Biol. Interact. (2003) [Pubmed]
  34. Effects of combined administration of captopril and DMSA on arsenite induced oxidative stress and blood and tissue arsenic concentration in rats. Kalia, K., Narula, G.D., Kannan, G.M., Flora, S.J. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2007) [Pubmed]
  35. Urine interleukin-6 and interleukin-8 in children with acute pyelonephritis, in relation to DMSA scintigraphy in the acute phase and at 1-year follow-up. Tullus, K., Fituri, O., Linné, T., Escobar-Billing, R., Wikstad, I., Karlsson, A., Burman, L.G., Wretlind, B., Brauner, A. Pediatric radiology. (1994) [Pubmed]
  36. Urinary N-acetyl-beta-glucosaminidase and beta-2-microglobulin in the diagnosis of urinary tract infection in febrile infants. Jantausch, B.A., Rifai, N., Getson, P., Akram, S., Majd, M., Wiedermann, B.L. Pediatr. Infect. Dis. J. (1994) [Pubmed]
  37. The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead. Rogan, W.J., Dietrich, K.N., Ware, J.H., Dockery, D.W., Salganik, M., Radcliffe, J., Jones, R.L., Ragan, N.B., Chisolm, J.J., Rhoads, G.G. N. Engl. J. Med. (2001) [Pubmed]
  38. Engraftment and differentiation of human metanephroi into functional mature nephrons after transplantation into mice is accompanied by a profile of gene expression similar to normal human kidney development. Dekel, B., Amariglio, N., Kaminski, N., Schwartz, A., Goshen, E., Arditti, F.D., Tsarfaty, I., Passwell, J.H., Reisner, Y., Rechavi, G. J. Am. Soc. Nephrol. (2002) [Pubmed]
  39. Urinary excretion of meso-2,3-dimercaptosuccinic acid in human subjects. Aposhian, H.V., Maiorino, R.M., Dart, R.C., Perry, D.F. Clin. Pharmacol. Ther. (1989) [Pubmed]
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