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Chemical Compound Review

Acadione     2-(2-sulfanylpropanoylamino) ethanoic acid

Synonyms: Captimer, Epatiol, Mucolysin, Sutilan, tiopronin, ...
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Disease relevance of Mercaptopropionylglycine


High impact information on Mercaptopropionylglycine


Chemical compound and disease context of Mercaptopropionylglycine


Biological context of Mercaptopropionylglycine


Anatomical context of Mercaptopropionylglycine


Associations of Mercaptopropionylglycine with other chemical compounds


Gene context of Mercaptopropionylglycine

  • The results have shown progressively decreasing amounts of PAI-1 in penicillamine, thiopronine and captopril-cultured tissue extracts, respectively [25].
  • Therefore, a detailed HLA class II typing might be useful before RA treatment by Tiopronin to predict and avoid toxic side effects in the patients with increased risk [26].
  • However, in women who received tiopronin and bromocriptine, the levels of PRL after 14 days of therapy were lower compared to the conservative treatment group [27].
  • Furthermore, in seven healthy women plasma PRL responses to thyrotropin-releasing hormone (TRH) before and after one week of tiopronin therapy (500 mg/day) were studied [27].
  • We report here that thiorphan and tiopronin are substrates for PAM, exhibiting relatively low K(M,app) and V(MAX,app) values [28].

Analytical, diagnostic and therapeutic context of Mercaptopropionylglycine


  1. Nephrotic syndrome induced by tiopronin: association with the HLA-DR3 antigen. Salvarani, C., Macchioni, P., Rossi, F., Iori, I., Filippi, G. Arthritis Rheum. (1985) [Pubmed]
  2. Local injections of tiopronin in Dupuytren's contracture. Cimmino, M.A., Cutolo, M., Beltrame, F. Arthritis Rheum. (1982) [Pubmed]
  3. Primary biliary cirrhosis. A patient with adverse reactions to tiopronin and autoimmune hemolytic anemia with reticulocytopenia. Shichiri, M., Koyama, W., Tozuka, S., Sakamoto, S., Kanayama, M. Arch. Intern. Med. (1984) [Pubmed]
  4. Chemical radioprotection to bone marrow stem cells after whole body gamma irradiation to mice. Dey, J., Dey, T.B., Ganguly, S.K., Nagpal, K.K., Ghose, A. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (1988) [Pubmed]
  5. Tiopronin in epilepsy. Rose, G.A. Lancet (1986) [Pubmed]
  6. Antiarthritic drugs containing thiol groups scavenge hypochlorite and inhibit its formation by myeloperoxidase from human leukocytes. A therapeutic mechanism of these drugs in rheumatoid arthritis? Cuperus, R.A., Muijsers, A.O., Wever, R. Arthritis Rheum. (1985) [Pubmed]
  7. Controlled multicenter trial of tiopronin and d-penicillamine for rheumatoid arthritis. Pasero, G., Pellegrini, P., Ambanelli, U., Ciompi, M.L., Colamussi, V., Ferraccioli, G., Barbieri, P., Mazzoni, M.R., Menegale, G., Trippi, D. Arthritis Rheum. (1982) [Pubmed]
  8. Electrospray mass spectrometry study of tiopronin monolayer-protected gold nanoclusters. Gies, A.P., Hercules, D.M., Gerdon, A.E., Cliffel, D.E. J. Am. Chem. Soc. (2007) [Pubmed]
  9. Nanoparticles comprising a mixed monolayer for specific bindings with biomolecules. Zheng, M., Huang, X. J. Am. Chem. Soc. (2004) [Pubmed]
  10. Exogenous NO triggers preconditioning via a cGMP- and mitoKATP-dependent mechanism. Qin, Q., Yang, X.M., Cui, L., Critz, S.D., Cohen, M.V., Browner, N.C., Lincoln, T.M., Downey, J.M. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  11. Tiopronin protects against the nephrotoxicity of cisplatin in rat renal cortical slices in vitro. Zhang, J.G., Lindup, W.E. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  12. Differential neutralizing effect of tiopronin on the toxicity of neocarzinostatin and SMANCS: a new rescue cancer chemotherapy. Oda, T., Yamamoto, H., Miki, T., Maeda, H. Jpn. J. Cancer Res. (1989) [Pubmed]
  13. Comparative effects of chelating agents on distribution, excretion, and renal toxicity of gold sodium thiomalate in rats. Takahashi, Y., Funakoshi, T., Shimada, H., Kojima, S. Toxicology (1994) [Pubmed]
  14. Urinary excretion of free cystine and the tiopronin-cysteine-mixed disulfide during long term tiopronin treatment of cystinuria. Lindell, A., Denneberg, T., Jeppsson, J.O. Nephron (1995) [Pubmed]
  15. DNA binding of an ethidium intercalator attached to a monolayer-protected gold cluster. Wang, G., Zhang, J., Murray, R.W. Anal. Chem. (2002) [Pubmed]
  16. Anti-oxidants show an anti-hypertensive effect in diabetic and hypertensive subjects. Ceriello, A., Giugliano, D., Quatraro, A., Lefebvre, P.J. Clin. Sci. (1991) [Pubmed]
  17. Efficacy of two-route chemotherapy using intraperitoneal neocarzinostatin and its antidote, intravenous tiopronin, for peritoneally disseminated tumors in mice. Hasuda, K., Kobayashi, H., Kuroiwa, T., Aoki, K., Taniguchi, S., Baba, T. Jpn. J. Cancer Res. (1989) [Pubmed]
  18. Nanoparticle targeting at cells. de la Fuente, J.M., Berry, C.C., Riehle, M.O., Curtis, A.S. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
  19. Tiopronin (2-mercaptopropionylglycine) has chemokinetic and chemotactic properties for polymorphonuclear leukocytes. Elferink, J.G., de Koster, B.M. Immunopharmacology (1992) [Pubmed]
  20. Mitochondrial sulfhydryl groups under oligomycin-inhibited, aging, and uncoupling conditions: beneficial influence of cardioprotective drugs. Fuchs, J., Freisleben, H.J., Mainka, L., Zimmer, G. Arch. Biochem. Biophys. (1988) [Pubmed]
  21. Evaluation of genotoxic and cytotoxic potential of thiola (N-2-mercaptopropionylglycine), a medicine used in the treatment of humans contaminated with mercury. Formigli, L.M., Ferrari, I., Grisolia, C.K. Environ. Mol. Mutagen. (2002) [Pubmed]
  22. Ion-pair chromatographic separation of water-soluble gold monolayer-protected clusters. Choi, M.M., Douglas, A.D., Murray, R.W. Anal. Chem. (2006) [Pubmed]
  23. Mercaptans decrease selenium-dependent glutathione peroxidase activity in the chick. Mercurio, S.D., Combs, G.F. J. Nutr. (1987) [Pubmed]
  24. High-performance liquid chromatography of 2-mercaptopropionylglycine and its metabolite 2-mercaptopropionic acid in plasma and urine after treatment with thiopronine. Kågedal, B., Andersson, T., Carlsson, M., Denneberg, T., Hoppe, A. J. Chromatogr. (1987) [Pubmed]
  25. Imbalance between plasminogen activator and its inhibitors in thiol-induced acantholysis. Lombardi, M.L., de Angelis, E., Rossano, F., Ruocco, V. Dermatology (Basel) (1993) [Pubmed]
  26. A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis. Ju, L.Y., Paolozzi, L., Delecoeuillerie, G., Bourgeois, P., Khodja, M., Legoff, P., Liote, F., Sheffer, V., Amor, B., Charron, D. Clinical and experimental rheumatology. (1994) [Pubmed]
  27. Inhibition of puerperal lactation with 2-mercaptopropionyl-glycine. Akrivis, C., Vezyraki, P., Kiortsis, D.N., Fotopoulos, A., Evangelou, A. Eur. J. Clin. Pharmacol. (2000) [Pubmed]
  28. Thiorphan, tiopronin, and related analogs as substrates and inhibitors of peptidylglycine alpha-amidating monooxygenase (PAM). McIntyre, N.R., Lowe, E.W., Chew, G.H., Owen, T.C., Merkler, D.J. FEBS Lett. (2006) [Pubmed]
  29. Continuous free-flow electrophoresis of water-soluble monolayer-protected clusters. Peterson, R.R., Cliffel, D.E. Anal. Chem. (2005) [Pubmed]
  30. Urinary cystine excretion and capacity in patients with cystinuria. Goldfarb, D.S., Coe, F.L., Asplin, J.R. Kidney Int. (2006) [Pubmed]
  31. Glyceraldehyde phosphate dehydrogenase oxidation during cardiac ischemia and reperfusion. Eaton, P., Wright, N., Hearse, D.J., Shattock, M.J. J. Mol. Cell. Cardiol. (2002) [Pubmed]
  32. Chemiluminescence determination of tiopronin by flow injection analysis based on cerium(IV) oxidation sensitized by quinine. Zhao, Y., Baeyens, W.R., Zhang, X., Calokerinos, A.C., Nakashima, K., Van der Weken, G. The Analyst. (1997) [Pubmed]
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