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Chemical Compound Review:

Advantan [ (6S,8R,9R,10S,11S,13S,14S,17R) -17-(2...

Synonyms: Advantan (TN), SureCN3466, SH-440, CHEMBL1697782, AC-6842, ...

Günther, C. et al., Lippert, U. et al.

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High impact information on SH-440

Six healthy, elderly volunteers received three topical treatments with Advantan lotion containing 0.1% of methylprednisolone aceponate (MPA, CAS 86401-95-8) on intact, inflamed and stripped skin in a consecutive fashion at weekly intervals [1].
Percutaneous absorption of methylprednisolone aceponate following topical application of Advantan lotion on intact, inflamed and stripped skin of male volunteers [1].
In the present study, we have investigated the influence of four potent glucocorticoids, methylprednisolone-aceponate, methylprednisolone-17-propionate, prednicarbate, and betametasone valerate (10(-5) M-10(-9) M), on the IL-1 beta, IL-3, IL-8, and tumor necrosis factor alpha secretion of the HMC-1 mast cell line as measured by ELISA [2].

References

Percutaneous absorption of methylprednisolone aceponate following topical application of Advantan lotion on intact, inflamed and stripped skin of male volunteers. Günther, C., Kecskes, A., Staks, T., Täuber, U. Skin Pharmacol. Appl. Skin Physiol. (1998) [Pubmed]
Modulation of in vitro cytokine release from human leukemic mast cells (HMC-1) by glucocorticoids. Lippert, U., Welker, P., Krüger-Krasagakes, S., Möller, A., Henz, B.M. Skin Pharmacol. (1996) [Pubmed]

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