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Chemical Compound Review:

TRIMETHYLLEAD trimethyllead

Synonyms: Trimethyl lead, AG-G-53668, LS-2179, AC1O3FED, CTK5C5784, ...

Blaszkewicz, M. et al., Gawrisch, E. et al., Röderer, G. et al., Heisterkamp, M. et al., Macaskie, L.E. et al., et al.

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Disease relevance of trimethyllead

An Arthrobacter sp. and a wood decay macrofungus, Phaeolus schweinitzii provide novel evidence for metabolic trimethyl lead (Me3Pb+) degradation [1].
Voltage-activated calcium channel currents of rat dorsal root ganglion cells are reduced by trimethyl lead [2].

High impact information on trimethyllead

Using the conventional whole-cell patch-clamp recording technique with cultured neurones of rat dorsal root ganglions (DRG), we analysed the effects of trimethyl lead (TML) on voltage-activated calcium channel currents [2].
Trimethyl lead degradation by free and immobilized cells of an Arthrobacter sp. and by the wood decay fungus Phaeolus schweinitzii [1].
Influence of trimethyl lead and inorganic lead on the in vitro assembly of microtubules from mammalian brain [3].
Trimethyl lead neurotoxicity in the rat: changes in glial fibrillary acidic protein (GFAP) [4].

Analytical, diagnostic and therapeutic context of trimethyllead

For the trimethyllead ion the validity of the results was examined by selectivity checks of the chemical reaction detector, by the application of different stationary and mobile phases in single and dual pre-column HPLC systems and by the use of thermospray LC-mass spectrometry as an independent method [5].
Identification of trimethyllead in urine by high-performance liquid chromatography with column switching and chemical reaction detection and by liquid chromatography-mass spectrometry [5].
Trimethyllead acetate: a first-choice heavy atom derivative for protein crystallography [6].
The accuracy of the system was confirmed by additional analysis of the water samples by capillary gas chromatography coupled with microwave-induced plasma-atomic-emission spectrometry and the analysis of a standard reference material CRM 605 (road dust) with a certified content of trimethyllead [7].
The influence of trimethyl lead (TriML) and inorganic lead (Pb) on the in vitro assembly of microtubules (MTs) from tubulin of porcine brain was studied using turbidity measurements and electron microscopy [3].

References

Trimethyl lead degradation by free and immobilized cells of an Arthrobacter sp. and by the wood decay fungus Phaeolus schweinitzii. Macaskie, L.E., Dean, A.C. Appl. Microbiol. Biotechnol. (1990) [Pubmed]
Voltage-activated calcium channel currents of rat dorsal root ganglion cells are reduced by trimethyl lead. Gawrisch, E., Leonhardt, R., Büsselberg, D. Toxicol. Lett. (1997) [Pubmed]
Influence of trimethyl lead and inorganic lead on the in vitro assembly of microtubules from mammalian brain. Röderer, G., Doenges, K.H. Neurotoxicology (1983) [Pubmed]
Trimethyl lead neurotoxicity in the rat: changes in glial fibrillary acidic protein (GFAP). Gong, Z., Little, A.R., el-Fawal, H., Evans, H.L. Arhiv za higijenu rada i toksikologiju. (1995) [Pubmed]
Identification of trimethyllead in urine by high-performance liquid chromatography with column switching and chemical reaction detection and by liquid chromatography-mass spectrometry. Blaszkewicz, M., Baumhoer, G., Neidhart, B., Ohlendorf, R., Linscheid, M. J. Chromatogr. (1988) [Pubmed]
Trimethyllead acetate: a first-choice heavy atom derivative for protein crystallography. Holden, H.M., Rayment, I. Arch. Biochem. Biophys. (1991) [Pubmed]
Gas chromatography--inductively coupled plasma--time-of-flight mass spectrometry for the speciation analysis of organolead compounds in environmental water samples. Heisterkamp, M., Adams, F.C. Fresenius' journal of analytical chemistry. (2001) [Pubmed]

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