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Gfap  -  glial fibrillary acidic protein

Rattus norvegicus

Synonyms: GFAP, Glial fibrillary acidic protein
 
 
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Disease relevance of Gfap

 

Psychiatry related information on Gfap

 

High impact information on Gfap

 

Chemical compound and disease context of Gfap

 

Biological context of Gfap

  • Changes were remarkably similar in both models, indicating a decreased cell proliferation in DG, an increased number of astrocytes immunopositive for GFAP and ApoE and a reduced number of hilar neurones [21].
  • More generally, we hypothesize that physiological variations in E2 levels modulate neuronal plasticity through direct effects on GFAP transcription that, in turn, modify GFAP-containing intermediate filaments and reorganize astrocytic laminin [22].
  • In the present work, as a preliminary step to the study of glial-specific gene expression, we cloned the rat GFAP gene, and we report the sequence of 1.9 kb of the 5' flanking region, exon 1, and the majority of the first intron [23].
  • Effect of reactive cell density on net [2-14C]acetate uptake into rat brain: labeling of clusters containing GFAP+- and lectin+-immunoreactive cells [24].
  • In the 5' flanking region we identified a CpG site at position -1176 whose level of methylation is inversely correlated to GFAP expression [23].
 

Anatomical context of Gfap

 

Associations of Gfap with chemical compounds

 

Physical interactions of Gfap

 

Co-localisations of Gfap

 

Regulatory relationships of Gfap

 

Other interactions of Gfap

  • The GFAP mRNA levels were also strongly increased following the bFGF injection [40].
  • After the treatment, a significant increase in the expression of neuronal cytoskeletal proteins (Nf-160, Nf-200, MAP-2) was observed, but we did not find changes in the expression of GFAP, the main astroglial cytoskeletal protein [41].
  • Expression of CNTF and GFAP mRNAs followed a time course similar to that of bFGF [42].
  • In addition, the morphological alterations were accompanied by increased in vitro 32P incorporation into GFAP and vimentin recovered into the high-salt Triton-insoluble cytoskeletal fraction [43].
  • The fate of endogenous stem cells in the brain was examined by the expression of the stem cell marker nestin, together with Tf, neurofilaments and glial fibrillary acidic protein from 2 to 14 days after injection [44].
 

Analytical, diagnostic and therapeutic context of Gfap

References

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  2. Basic fibroblast growth factor, neurofilament, and glial fibrillary acidic protein immunoreactivities in the myenteric plexus of the rat esophagus and colon. Chadi, G., Gomide, V.C., Rodrigues de Souza, R., Scabello, R.T., Maurício da Silva, C. J. Morphol. (2004) [Pubmed]
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  17. GDNF is a major component of trophic activity in DA-depleted striatum for survival and neurite extension of DAergic neurons. Nakajima, K., Hida, H., Shimano, Y., Fujimoto, I., Hashitani, T., Kumazaki, M., Sakurai, T., Nishino, H. Brain Res. (2001) [Pubmed]
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  22. Estradiol (E2) enhances neurite outgrowth by repressing glial fibrillary acidic protein expression and reorganizing laminin. Rozovsky, I., Wei, M., Stone, D.J., Zanjani, H., Anderson, C.P., Morgan, T.E., Finch, C.E. Endocrinology (2002) [Pubmed]
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  24. Effect of reactive cell density on net [2-14C]acetate uptake into rat brain: labeling of clusters containing GFAP+- and lectin+-immunoreactive cells. Cetin, N., Ball, K., Gokden, M., Cruz, N.F., Dienel, G.A. Neurochem. Int. (2003) [Pubmed]
  25. Altered motor function and graft survival produced by basic fibroblast growth factor in rats with 6-OHDA lesions and fetal ventral mesencephalic grafts are associated with glial proliferation. Zeng, B.Y., Jenner, P., Marsden, C.D. Exp. Neurol. (1996) [Pubmed]
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  28. Messenger RNA for glial fibrillary acidic protein is decreased in rat brain following acute and chronic corticosterone treatment. Nichols, N.R., Osterburg, H.H., Masters, J.N., Millar, S.L., Finch, C.E. Brain Res. Mol. Brain Res. (1990) [Pubmed]
  29. Differential regulation of AP-1 and novel TRE-specific DNA-binding complexes during differentiation of oligodendrocyte-type-2-astrocyte (O-2A) progenitor cells. Barnett, S.C., Rosario, M., Doyle, A., Kilbey, A., Lovatt, A., Gillespie, D.A. Development (1995) [Pubmed]
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  31. Astroglial ciliary neurotrophic factor mRNA expression is increased in fields of axonal sprouting in deafferented hippocampus. Guthrie, K.M., Woods, A.G., Nguyen, T., Gall, C.M. J. Comp. Neurol. (1997) [Pubmed]
  32. Activation of embryonic intermediate filaments contributes to glial scar formation after spinal cord injury in rats. Kim, D.H., Heo, S.D., Ahn, M.J., Sim, K.B., Shin, T.K. J. Vet. Sci. (2003) [Pubmed]
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  35. Changes in mitotic rate and GFAP expression in the primary olfactory axis of streptozotocin-induced diabetic rats. Dennis, J.C., Coleman, E.S., Swyers, S.E., Moody, S.W., Wright, J.C., Judd, R., Zhong, Q., Morrison, E.E. J. Neurocytol. (2005) [Pubmed]
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  38. Intracisternal TRH analog induces Fos expression in gastric myenteric neurons and glia in conscious rats. Miampamba, M., Yang, H., Sharkey, K.A., Taché, Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  39. Induction of heme oxygenase-1 after hyperosmotic opening of the blood-brain barrier. Richmon, J.D., Fukuda, K., Maida, N., Sato, M., Bergeron, M., Sharp, F.R., Panter, S.S., Noble, L.J. Brain Res. (1998) [Pubmed]
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  41. Neuronal cytoskeleton and synaptic densities are altered after a chronic treatment with the cannabinoid receptor agonist WIN 55,212-2. Tagliaferro, P., Javier Ramos, A., Onaivi, E.S., Evrard, S.G., Lujilde, J., Brusco, A. Brain Res. (2006) [Pubmed]
  42. Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP and IGF-I in the rat retina. Cao, W., Li, F., Steinberg, R.H., Lavail, M.M. Exp. Eye Res. (2001) [Pubmed]
  43. Propionic acid induces cytoskeletal alterations in cultured astrocytes from rat cerebral cortex. de Almeida, L.M., Funchal, C., Gottfried, C., Wajner, M., Pessoa-Pureur, R. Metabolic brain disease. (2006) [Pubmed]
  44. Activation, Proliferation and Commitment of Endogenous Stem/Progenitor Cells to the Oligodendrocyte Lineage by TS1 in a Rat Model of Dysmyelination. Espinosa-Jeffrey, A., Zhao, P., Awosika, W., Wu, N., Macias, F., Cepeda, C., Levine, M., de Vellis, J. Dev. Neurosci. (2006) [Pubmed]
  45. Exposure of cultured astroglial and microglial brain cells to 900 MHz microwave radiation. Thorlin, T., Rouquette, J.M., Hamnerius, Y., Hansson, E., Persson, M., Björklund, U., Rosengren, L., Rönnbäck, L., Persson, M. Radiat. Res. (2006) [Pubmed]
  46. Isolation of cDNA clones encoding rat glial fibrillary acidic protein: expression in astrocytes and in Schwann cells. Feinstein, D.L., Weinmaster, G.A., Milner, R.J. J. Neurosci. Res. (1992) [Pubmed]
 
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