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Gene Review

Gfap  -  glial fibrillary acidic protein

Rattus norvegicus

Synonyms: GFAP, Glial fibrillary acidic protein
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Disease relevance of Gfap


Psychiatry related information on Gfap


High impact information on Gfap


Chemical compound and disease context of Gfap


Biological context of Gfap

  • Changes were remarkably similar in both models, indicating a decreased cell proliferation in DG, an increased number of astrocytes immunopositive for GFAP and ApoE and a reduced number of hilar neurones [21].
  • More generally, we hypothesize that physiological variations in E2 levels modulate neuronal plasticity through direct effects on GFAP transcription that, in turn, modify GFAP-containing intermediate filaments and reorganize astrocytic laminin [22].
  • In the present work, as a preliminary step to the study of glial-specific gene expression, we cloned the rat GFAP gene, and we report the sequence of 1.9 kb of the 5' flanking region, exon 1, and the majority of the first intron [23].
  • Effect of reactive cell density on net [2-14C]acetate uptake into rat brain: labeling of clusters containing GFAP+- and lectin+-immunoreactive cells [24].
  • In the 5' flanking region we identified a CpG site at position -1176 whose level of methylation is inversely correlated to GFAP expression [23].

Anatomical context of Gfap


Associations of Gfap with chemical compounds


Physical interactions of Gfap


Co-localisations of Gfap


Regulatory relationships of Gfap


Other interactions of Gfap

  • The GFAP mRNA levels were also strongly increased following the bFGF injection [40].
  • After the treatment, a significant increase in the expression of neuronal cytoskeletal proteins (Nf-160, Nf-200, MAP-2) was observed, but we did not find changes in the expression of GFAP, the main astroglial cytoskeletal protein [41].
  • Expression of CNTF and GFAP mRNAs followed a time course similar to that of bFGF [42].
  • In addition, the morphological alterations were accompanied by increased in vitro 32P incorporation into GFAP and vimentin recovered into the high-salt Triton-insoluble cytoskeletal fraction [43].
  • The fate of endogenous stem cells in the brain was examined by the expression of the stem cell marker nestin, together with Tf, neurofilaments and glial fibrillary acidic protein from 2 to 14 days after injection [44].

Analytical, diagnostic and therapeutic context of Gfap


  1. Effects of 1alpha,25 dihydroxyvitamin D3 on the expression of HO-1 and GFAP in glial cells of the photothrombotically lesioned cerebral cortex. Oermann, E., Bidmon, H.J., Witte, O.W., Zilles, K. J. Chem. Neuroanat. (2004) [Pubmed]
  2. Basic fibroblast growth factor, neurofilament, and glial fibrillary acidic protein immunoreactivities in the myenteric plexus of the rat esophagus and colon. Chadi, G., Gomide, V.C., Rodrigues de Souza, R., Scabello, R.T., Maurício da Silva, C. J. Morphol. (2004) [Pubmed]
  3. Downregulation of osteoblast markers and induction of the glial fibrillary acidic protein by oncostatin M in osteosarcoma cells require PKCdelta and STAT3. Chipoy, C., Berreur, M., Couillaud, S., Pradal, G., Vallette, F., Colombeix, C., Rédini, F., Heymann, D., Blanchard, F. J. Bone Miner. Res. (2004) [Pubmed]
  4. Effects of diabetes mellitus on astrocyte GFAP and glutamate transporters in the CNS. Coleman, E., Judd, R., Hoe, L., Dennis, J., Posner, P. Glia (2004) [Pubmed]
  5. Divergent glial fibrillary acidic protein and its mRNA in the activated supraoptic nucleus. Lally, B.E., Albrecht, P.J., Levison, S.W., Salm, A.K. Neurosci. Lett. (2005) [Pubmed]
  6. Electroconvulsive shock and lidocaine-induced seizures in the rat activate astrocytes as measured by glial fibrillary acidic protein. Kragh, J., Bolwig, T.G., Woldbye, D.P., Jørgensen, O.S. Biol. Psychiatry (1993) [Pubmed]
  7. The role of postlesion seizures and spreading depression in the upregulation of glial fibrillary acidic protein mRNA after entorhinal cortex lesions. Kelley, M.S., Steward, O. Exp. Neurol. (1996) [Pubmed]
  8. Behavioural correlates of striatal glial fibrillary acidic protein in the 3-nitropropionic acid rat model: disturbed walking pattern and spatial orientation. Teunissen, C.E., Steinbusch, H.W., Angevaren, M., Appels, M., de Bruijn, C., Prickaerts, J., de Vente, J. Neuroscience (2001) [Pubmed]
  9. Alterations in CNS gene expression in a rodent model of moderate traumatic brain injury complicated by acute alcohol intoxication. Sall, J.M., Morehead, M., Murphy, S., Goldman, H., Walker, P.D. Exp. Neurol. (1996) [Pubmed]
  10. Lower packing density of glial fibrillary acidic protein-immunoreactive astrocytes in the prelimbic cortex of alcohol-naive and alcohol-drinking alcohol-preferring rats as compared with alcohol-nonpreferring and Wistar rats. Miguel-Hidalgo, J.J. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  11. Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture. Hughes, S.M., Lillien, L.E., Raff, M.C., Rohrer, H., Sendtner, M. Nature (1988) [Pubmed]
  12. Glial cells in the enteric nervous system contain glial fibrillary acidic protein. Jessen, K.R., Mirsky, R. Nature (1980) [Pubmed]
  13. High-affinity uptake of serotonin into immunocytochemically identified astrocytes. Kimelberg, H.K., Katz, D.M. Science (1985) [Pubmed]
  14. FGF2-induced chromatin remodeling regulates CNTF-mediated gene expression and astrocyte differentiation. Song, M.R., Ghosh, A. Nat. Neurosci. (2004) [Pubmed]
  15. Early effects of iodine deficiency on radial glial cells of the hippocampus of the rat fetus. A model of neurological cretinism. Martínez-Galán, J.R., Pedraza, P., Santacana, M., Escobar del Ray, F., Morreale de Escobar, G., Ruiz-Marcos, A. J. Clin. Invest. (1997) [Pubmed]
  16. Isolation and characterization of a new immortal rat astrocyte with a high expression of NGF mRNA. Morikawa, M., Asai, K., Kokubo, M., Fujita, K., Yoneda, K., Yamamoto, N., Inoue, Y., Iida, J., Kishimoto, T., Kato, T. Neurosci. Res. (2001) [Pubmed]
  17. GDNF is a major component of trophic activity in DA-depleted striatum for survival and neurite extension of DAergic neurons. Nakajima, K., Hida, H., Shimano, Y., Fujimoto, I., Hashitani, T., Kumazaki, M., Sakurai, T., Nishino, H. Brain Res. (2001) [Pubmed]
  18. Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage. Culmsee, C., Stumm, R.K., Schäfer, M.K., Weihe, E., Krieglstein, J. Eur. J. Pharmacol. (1999) [Pubmed]
  19. Synthesis of glial fibrillary acidic protein in rat C6 glioma in chemically defined medium: cyclic AMP-dependent transcriptional and translational regulation. Messens, J., Slegers, H. J. Neurochem. (1992) [Pubmed]
  20. Serotonergic reinnervation reverses lesion-induced decreases in PSA-NCAM labeling and proliferation of hippocampal cells in adult rats. Brezun, J.M., Daszuta, A. Hippocampus. (2000) [Pubmed]
  21. Abnormalities of the hippocampus are similar in deoxycorticosterone acetate-salt hypertensive rats and spontaneously hypertensive rats. Pietranera, L., Saravia, F., Gonzalez Deniselle, M.C., Roig, P., Lima, A., De Nicola, A.F. J. Neuroendocrinol. (2006) [Pubmed]
  22. Estradiol (E2) enhances neurite outgrowth by repressing glial fibrillary acidic protein expression and reorganizing laminin. Rozovsky, I., Wei, M., Stone, D.J., Zanjani, H., Anderson, C.P., Morgan, T.E., Finch, C.E. Endocrinology (2002) [Pubmed]
  23. Tissue-specific DNA methylation patterns of the rat glial fibrillary acidic protein gene. Condorelli, D.F., Nicoletti, V.G., Barresi, V., Caruso, A., Conticello, S., de Vellis, J., Giuffrida Stella, A.M. J. Neurosci. Res. (1994) [Pubmed]
  24. Effect of reactive cell density on net [2-14C]acetate uptake into rat brain: labeling of clusters containing GFAP+- and lectin+-immunoreactive cells. Cetin, N., Ball, K., Gokden, M., Cruz, N.F., Dienel, G.A. Neurochem. Int. (2003) [Pubmed]
  25. Altered motor function and graft survival produced by basic fibroblast growth factor in rats with 6-OHDA lesions and fetal ventral mesencephalic grafts are associated with glial proliferation. Zeng, B.Y., Jenner, P., Marsden, C.D. Exp. Neurol. (1996) [Pubmed]
  26. Immunocytochemical localization of basic fibroblast growth factor and glial fibrillary acidic protein after laser photocoagulation in the Royal College of Surgeons rat. Chu, Y., Humphrey, M.F., Alder, V.V., Constable, I.J. Australian and New Zealand journal of ophthalmology. (1998) [Pubmed]
  27. Bone morphogenetic proteins: neurotrophic roles for midbrain dopaminergic neurons and implications of astroglial cells. Jordan, J., Böttner, M., Schluesener, H.J., Unsicker, K., Krieglstein, K. Eur. J. Neurosci. (1997) [Pubmed]
  28. Messenger RNA for glial fibrillary acidic protein is decreased in rat brain following acute and chronic corticosterone treatment. Nichols, N.R., Osterburg, H.H., Masters, J.N., Millar, S.L., Finch, C.E. Brain Res. Mol. Brain Res. (1990) [Pubmed]
  29. Differential regulation of AP-1 and novel TRE-specific DNA-binding complexes during differentiation of oligodendrocyte-type-2-astrocyte (O-2A) progenitor cells. Barnett, S.C., Rosario, M., Doyle, A., Kilbey, A., Lovatt, A., Gillespie, D.A. Development (1995) [Pubmed]
  30. GRP78-binding protein regulates cAMP-induced glial fibrillary acidic protein expression in rat C6 glioblastoma cells. Oh-hashi, K., Hirata, Y., Koga, H., Kiuchi, K. FEBS Lett. (2006) [Pubmed]
  31. Astroglial ciliary neurotrophic factor mRNA expression is increased in fields of axonal sprouting in deafferented hippocampus. Guthrie, K.M., Woods, A.G., Nguyen, T., Gall, C.M. J. Comp. Neurol. (1997) [Pubmed]
  32. Activation of embryonic intermediate filaments contributes to glial scar formation after spinal cord injury in rats. Kim, D.H., Heo, S.D., Ahn, M.J., Sim, K.B., Shin, T.K. J. Vet. Sci. (2003) [Pubmed]
  33. Distribution of alpha- and gamma-synucleins in the adult rat brain and their modification by high-dose cocaine treatment. Brenz Verca, M.S., Bahi, A., Boyer, F., Wagner, G.C., Dreyer, J.L. Eur. J. Neurosci. (2003) [Pubmed]
  34. N-acetylated alpha-linked acidic dipeptidase is expressed by non-myelinating Schwann cells in the peripheral nervous system. Berger, U.V., Carter, R.E., McKee, M., Coyle, J.T. J. Neurocytol. (1995) [Pubmed]
  35. Changes in mitotic rate and GFAP expression in the primary olfactory axis of streptozotocin-induced diabetic rats. Dennis, J.C., Coleman, E.S., Swyers, S.E., Moody, S.W., Wright, J.C., Judd, R., Zhong, Q., Morrison, E.E. J. Neurocytol. (2005) [Pubmed]
  36. Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain. Ip, N.Y., Wiegand, S.J., Morse, J., Rudge, J.S. Eur. J. Neurosci. (1993) [Pubmed]
  37. Alterations in fibroblast growth factor receptor expression following brain injury. Reilly, J.F., Kumari, V.G. Exp. Neurol. (1996) [Pubmed]
  38. Intracisternal TRH analog induces Fos expression in gastric myenteric neurons and glia in conscious rats. Miampamba, M., Yang, H., Sharkey, K.A., Taché, Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  39. Induction of heme oxygenase-1 after hyperosmotic opening of the blood-brain barrier. Richmon, J.D., Fukuda, K., Maida, N., Sato, M., Bergeron, M., Sharp, F.R., Panter, S.S., Noble, L.J. Brain Res. (1998) [Pubmed]
  40. Basic fibroblast growth factor (bFGF) injection activates the glial reaction in the injured adult rat brain. Eclancher, F., Kehrli, P., Labourdette, G., Sensenbrenner, M. Brain Res. (1996) [Pubmed]
  41. Neuronal cytoskeleton and synaptic densities are altered after a chronic treatment with the cannabinoid receptor agonist WIN 55,212-2. Tagliaferro, P., Javier Ramos, A., Onaivi, E.S., Evrard, S.G., Lujilde, J., Brusco, A. Brain Res. (2006) [Pubmed]
  42. Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP and IGF-I in the rat retina. Cao, W., Li, F., Steinberg, R.H., Lavail, M.M. Exp. Eye Res. (2001) [Pubmed]
  43. Propionic acid induces cytoskeletal alterations in cultured astrocytes from rat cerebral cortex. de Almeida, L.M., Funchal, C., Gottfried, C., Wajner, M., Pessoa-Pureur, R. Metabolic brain disease. (2006) [Pubmed]
  44. Activation, Proliferation and Commitment of Endogenous Stem/Progenitor Cells to the Oligodendrocyte Lineage by TS1 in a Rat Model of Dysmyelination. Espinosa-Jeffrey, A., Zhao, P., Awosika, W., Wu, N., Macias, F., Cepeda, C., Levine, M., de Vellis, J. Dev. Neurosci. (2006) [Pubmed]
  45. Exposure of cultured astroglial and microglial brain cells to 900 MHz microwave radiation. Thorlin, T., Rouquette, J.M., Hamnerius, Y., Hansson, E., Persson, M., Björklund, U., Rosengren, L., Rönnbäck, L., Persson, M. Radiat. Res. (2006) [Pubmed]
  46. Isolation of cDNA clones encoding rat glial fibrillary acidic protein: expression in astrocytes and in Schwann cells. Feinstein, D.L., Weinmaster, G.A., Milner, R.J. J. Neurosci. Res. (1992) [Pubmed]
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