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Chemical Compound Review:

AC1O3MDH [[N'-(4-amino-4-carboxy...

Synonyms:

Monaco, J.A. et al., Hecker, M. et al., Colas, B. et al., Meadow, W. et al.

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Disease relevance of NITROARGININE

In the presence of both NLA and AT, baseline PAP increased from 4.25 +/- 0.8 to 9.9 +/- 0.92 mmHg (P < or = 0.05), but hypoxia did not significantly increase PAP and the reoxygenation response was inhibited [1].

High impact information on NITROARGININE

Bradykinin or moexiprilat also significantly increased the cyclic guanosine monophosphate (cGMP) content of these coronary segments, an effect which was abolished by the nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine (NNA), or by removal of the endothelium [2].
Similarly, relative cerebral vascular resistance (CVR/SVR) fell significantly during LAB and NNLA but rose during INDO.(ABSTRACT TRUNCATED AT 250 WORDS)[3]
Additionally, while NLA did not affect the vasodilation that occurs upon reoxygenation, AT inhibited the immediate response to reoxygenation [1].

Associations of NITROARGININE with other chemical compounds

Although not modified by indomethacin, this inhibition was attenuated by either mechanical removal of the endothelium or N omega-nitro-L-arginine (NOLA) treatment [4].

References

NO and H2O2 mechanisms of guanylate cyclase activation in oxygen-dependent responses of rat pulmonary circulation. Monaco, J.A., Burke-Wolin, T. Am. J. Physiol. (1995) [Pubmed]
Angiotensin-converting enzyme inhibitors unmask endogenous kinin production by bovine coronary artery endothelium. Hecker, M., Bara, A.T., Busse, R. Eur. Heart J. (1993) [Pubmed]
The role of prostaglandins and endothelium-derived relaxation factor in the regulation of cerebral blood flow and cerebral oxygen utilization in the piglet: operationalizing the concept of an essential circulation. Meadow, W., Rudinsky, B., Bell, A., Lozon, M., Randle, C., Hipps, R. Pediatr. Res. (1994) [Pubmed]
Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta. Colas, B., Slama, M., Collin, T., Safar, M., Andrejak, M. Eur. J. Pharmacol. (2000) [Pubmed]

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