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Chemical Compound Review:

CANDIDIN (4E,6E,8E,10E,12E,14E,16E)-3- (4-amino-3,5...

Synonyms: AC1O5FWR, 1405-90-9, EINECS 215-788-3, 8,9-Dideoxy-10-hydroxy-7-oxoamphotericin B, Amphotericin B, 8,9-dideoxy-10-hydroxy-7-oxo-

Vanderbeeken, Y.E. et al., Vanderbeeken, Y.E. et al., Vanderbeeken, Y.E. et al., Restrepo, A. et al., Martinon, F. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Candidine

The skin tests with Varidase, Candidine, Mumps antigen and DNCB were not significantly different at onset and in remission [1].

High impact information on Candidine

When third party lymphocytes were stimulated by Candidine or unrelated mononuclear cells in the presence of retroplacental serum, only the cellular subpopulation belonging to the CD4+ subset showed an HLA Dq. downregulation [2].
A significant downregulation of the candidine mediated lymphocytic stimulation was observed in the case of the maternal serum [3].
The same CD4 positive inhibitive property of maternal serum was observed when a neoplastic cell line (HUT cells) was used as target for candidine in a stimulation test [3].
When third party lymphocytes and mononuclear cord blood cells were stimulated by Candidine or unrelated mononuclear cells in the presence of retroplacental serum, only the cellular subpopulation belonging to the CD4+ subset showed an HLADq downregulation [4].
BUdR-EIA was compared to 3H-thymidine incorporating assay for the measure of lymphocyte proliferation induced by PHA mitogen, candidine and tuberculine antigens and mixed lymphocyte culture [5].

Analytical, diagnostic and therapeutic context of Candidine

Also, untreated patients exhibited the lowest skin test responses to PHA, purified protein derivative (PPD), P and candidin (C); significant differences, however, were limited to the former 2 antigens [6].

References

Immune status in children with acute lymphocytic leukemia. Observations in 67 cases. Bardare, M., Pietrogrande, M.C., Corona, F., Varin, E., Carnelli, V., Masera, G. Helvetica paediatrica acta. (1978) [Pubmed]
Modulation of the HLA class II antigen at a molecular level by maternal serum. Vanderbeeken, Y.E., Duchateau, J., Colletl, H., Gregoire, M., Desseilles, P., Lucas, A. Immunopharmacology and immunotoxicology. (1990) [Pubmed]
Functional modifications of the CD4+ and the CD8+ subset due to maternal serum. Vanderbeeken, Y.E., Duchateau, J., Collet, H., Van Boogaert, L., Desseilles, P., Lucas, A. Immunopharmacology and immunotoxicology. (1989) [Pubmed]
Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated lymphocytes. Vanderbeeken, Y.E., Duchateau, J., Colle, H., Gregoire, M., Desseilles, P., Lucas, A. Arch. Gynecol. Obstet. (1991) [Pubmed]
In vitro proliferation of human lymphocytes measured by an enzyme immunoassay using an anti-5-bromo-2-deoxyuridine monoclonal antibody. Martinon, F., Rabian, C., Loiseau, P., Ternynck, T., Avrameas, S., Colombani, J. Journal of clinical & laboratory immunology. (1987) [Pubmed]
Immune responses in paracoccidioidomycosis. A controlled study of 16 patients before and after treatment. Restrepo, A., Restrepo, M., de Restrepo, F., Aristizábal, L.H., Moncada, L.H., Vélez, H. Sabouraudia. (1978) [Pubmed]

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