The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Fetal Blood

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Fetal Blood

  • Of eight cord-blood samples from neonates with proved HIV infection, five were positive for immune-complex-dissociated p24 antigen [1].
  • We identified these vermiform structures in toluidine blue O-stained venous blood smears from four women with preeclampsia, cord blood taken at delivery of three of their neonates, and venous blood from five control subjects without preeclampsia and from five healthy beagle dogs [2].
  • GSH and NAC suppressed the replication of HIV-1 in both primary cord blood and adult donor MDM in a concentration dependent fashion [3].
  • Parvovirus B19-infected erythroblasts in fetal cord blood [4].
  • When injected separately into nonobese diabetic-severe combined immunodeficient (NOD/SCID) mice or in competition with control vector-transduced cells, HOXB4-overexpressing cord blood CD34+ cells had a selective growth advantage in vivo, which resulted in a marked enhancement of the primitive CD34+ subpopulation (P =.01) [5].

Psychiatry related information on Fetal Blood


High impact information on Fetal Blood

  • RESULTS: Recipients of cord blood were younger than recipients of bone marrow (median age, 5 years vs. 8 years; P<0.001), weighed less (median weight, 17 kg vs. 26 kg; P<0.001), and were less likely to have received methotrexate for prophylaxis against GVHD (28 percent vs. 65 percent, P<0.001) [8].
  • Smad2 function is not required for mesoderm production per se, but, rather unexpectedly, in the absence of Smad2 the entire epiblast adopts a mesodermal fate giving rise to a normal yolk sac and fetal blood cells [9].
  • BACKGROUND: Cord-blood banks have increased the use of cord-blood transplantation in patients with hematologic disorders [10].
  • Although more BFU-E-derived colonies appeared when 200 or 2000 mU were present per milliliter in cultures of the infants' blood and cord blood, the intrinsic responsiveness of BFU-E to erythropoietin was similar in all groups [11].
  • Fetal blood was obtained by placental aspiration for measurement of plasma creatine phosphokinase activity [12].

Chemical compound and disease context of Fetal Blood


Biological context of Fetal Blood


Anatomical context of Fetal Blood

  • CD40-activated cord blood CD34HPC were found to proliferate and differentiate independently of granulocyte/macrophage colony-stimulating factor, into a cell population with prominent dendritic cell (DC) attributes including priming of allogeneic naive T cells [23].
  • Here a new, intrinsically pluripotent, CD45-negative population from human cord blood, termed unrestricted somatic stem cells (USSCs) is described [24].
  • When human peripheral blood or cord blood lymphocytes are cultured in the presence of PBM, a high level of thymidine incorporation by these cells is detected [25].
  • We have identified a chemokine receptor which appears to be selectively expressed in human dendritic cells derived from CD34+ cord blood precursors, but not in dendritic cells derived from peripheral blood monocytes [26].
  • The long-term suspension growth of normal, immature myeloid cells from fresh human cord blood was recently reported and required cells separated on supplemented discontinuous Percoll gradients, growth in media containing hydrocortisone and vitamins D3, and gentle, continuous agitation (13) [27].

Associations of Fetal Blood with chemical compounds

  • A review of the data for fetal cortisol levels at delivery suggests that many of the values published over the past decade are too high owing to the use of methods insufficiently specific for cortisol in cord blood [28].
  • The increase in fetal O2 consumption was accompanied by a significant increase in fetal O2 extraction with no change in either fetal O2 delivery or fetal blood O2 affinity [29].
  • Betamethasone in cord blood was 14.3 microg cortisol equivalents per 100 ml at 1 h, decreased to a level of 4.7 at 20 h, and was not detected 2 days after a second dose at 24 h [30].
  • At 4 h of age the mean serum rT3 concentration (165 plus or minus 13 ng per 100 ml) in six newborns was 4ot significantly different from that in paired cord blood samples (194 plus or minus 25 ng per 100 ml); on the other hand, whenever, studied, the mean serum T3 and T4 levels were significantly higher at 4 h than at birth [31].
  • Since increased serum concentrations of 1,25-dihydroxyvitamin D have been reported in this disease, we have examined the capacity of HTLV-I-infected cord blood lymphocytes to metabolize 25-hydroxyvitamin D3 [32].

Gene context of Fetal Blood

  • We have characterized committed hPrMCs and fully mature hMCs derived in vitro from cord blood for their functional responses to chemokine and cytokine agonists germane to allergic inflammation and for their maturation-related expression of the corresponding receptors [33].
  • CD40 ligation on human cord blood CD34+ hematopoietic progenitors induces their proliferation and differentiation into functional dendritic cells [23].
  • However, we demonstrate that SCID-repopulating cells present in the CD34(+) cell fraction of cord blood can be segregated into subpopulations with distinct repopulation characteristics [34].
  • Interestingly, cord blood cell cultures performed with IL-3 contained variable percentages of eosinophils that were further enhanced in the presence of combinations of IL-3 and IL-4 [35].
  • Interleukin-4 has basophilic and eosinophilic cell growth-promoting activity on cord blood cells [35].

Analytical, diagnostic and therapeutic context of Fetal Blood


  1. Rapid serologic testing with immune-complex-dissociated HIV p24 antigen for early detection of HIV infection in neonates. Southern California Pediatric AIDS Consortium. Miles, S.A., Balden, E., Magpantay, L., Wei, L., Leiblein, A., Hofheinz, D., Toedter, G., Stiehm, E.R., Bryson, Y. N. Engl. J. Med. (1993) [Pubmed]
  2. The question of a helminthic cause of preeclampsia. Richards, F.O., Grimes, D.A., Wilson, M. JAMA (1983) [Pubmed]
  3. Thiol suppression of human immunodeficiency virus type 1 replication in primary cord blood monocyte-derived macrophages in vitro. Lioy, J., Ho, W.Z., Cutilli, J.R., Polin, R.A., Douglas, S.D. J. Clin. Invest. (1993) [Pubmed]
  4. Parvovirus B19-infected erythroblasts in fetal cord blood. Nerlich, A., Schwarz, T.F., Roggendorf, M., Roggendorf, H., Ostermeyer, E., Schramm, T., Gloning, K.P. Lancet (1991) [Pubmed]
  5. High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation. Schiedlmeier, B., Klump, H., Will, E., Arman-Kalcek, G., Li, Z., Wang, Z., Rimek, A., Friel, J., Baum, C., Ostertag, W. Blood (2003) [Pubmed]
  6. Maternal and fetal effects of acetaminophen and salicylates in pregnancy. Collins, E. Obstetrics and gynecology. (1981) [Pubmed]
  7. Neurobehavioral effects of intrauterine mercury exposure: potential sources of bias. Grandjean, P., Weihe, P. Environmental research. (1993) [Pubmed]
  8. Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources. Rocha, V., Wagner, J.E., Sobocinski, K.A., Klein, J.P., Zhang, M.J., Horowitz, M.M., Gluckman, E. N. Engl. J. Med. (2000) [Pubmed]
  9. Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Waldrip, W.R., Bikoff, E.K., Hoodless, P.A., Wrana, J.L., Robertson, E.J. Cell (1998) [Pubmed]
  10. Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. Gluckman, E., Rocha, V., Boyer-Chammard, A., Locatelli, F., Arcese, W., Pasquini, R., Ortega, J., Souillet, G., Ferreira, E., Laporte, J.P., Fernandez, M., Chastang, C. N. Engl. J. Med. (1997) [Pubmed]
  11. Circulating erythroid progenitors in the anemia of prematurity. Shannon, K.M., Naylor, G.S., Torkildson, J.C., Clemons, G.K., Schaffner, V., Goldman, S.L., Lewis, K., Bryant, P., Phibbs, R. N. Engl. J. Med. (1987) [Pubmed]
  12. Prenatal diagnosis of Duchenne's muscular dystrophy. Mahoney, M.J., Haseltine, F.P., Hobbins, J.C., Banker, B.Q., Caskey, C.T., Golbus, M.S. N. Engl. J. Med. (1977) [Pubmed]
  13. Effect of human immunodeficiency virus type-1 envelope glycoprotein gp160 on cytokine production from cord-blood T cells. Than, S., Oyaizu, N., Pahwa, R.N., Kalyanaraman, V.S., Pahwa, S. Blood (1994) [Pubmed]
  14. Didanosine, interferon-alfa and ribavirin: a highly synergistic combination with potential activity against HIV-1 and hepatitis C virus. Klein, M.B., Campeol, N., Lalonde, R.G., Brenner, B., Wainberg, M.A. AIDS (2003) [Pubmed]
  15. 3,3',5'-triiodothyronine, thyroxine, triiodothyronine, and thyrotropin levels in maternal and cord blood sera from endemic goiter regions of Brazil. Medeiros-Neto, G.A., Walfish, P.G., Almeida, F., Maia, E., Gomes, E.F., Kiy, Y., Knobel, M., Ginsberg, J., Chopra, I.J. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  16. High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. Sachan, A., Gupta, R., Das, V., Agarwal, A., Awasthi, P.K., Bhatia, V. Am. J. Clin. Nutr. (2005) [Pubmed]
  17. Negative feedback regulation of adrenocorticotropin secretion by cortisol in ovine fetuses. Wood, C.E., Rudolph, A.M. Endocrinology (1983) [Pubmed]
  18. Disposition and pharmacodynamics of methamphetamine in pregnant sheep. Burchfield, D.J., Lucas, V.W., Abrams, R.M., Miller, R.L., DeVane, C.L. JAMA (1991) [Pubmed]
  19. Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells. Kadowaki, N., Antonenko, S., Ho, S., Rissoan, M.C., Soumelis, V., Porcelli, S.A., Lanier, L.L., Liu, Y.J. J. Exp. Med. (2001) [Pubmed]
  20. Quantitation of human gamma globin genes and gamma globin mRNA with purified gamma globin complementary DNA. Ramirez, F., O'Donnell, J.V., Natta, C., Bank, A. J. Clin. Invest. (1976) [Pubmed]
  21. Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development. Sakashita, K., Koike, K., Kinoshita, T., Shiohara, M., Kamijo, T., Taniguchi, S., Kubota, T. J. Clin. Invest. (2001) [Pubmed]
  22. Fructosamine in diabetic pregnancy. Roberts, A.B., Baker, J.R., Court, D.J., James, A.G., Henley, P., Ronayne, I.D. Lancet (1983) [Pubmed]
  23. CD40 ligation on human cord blood CD34+ hematopoietic progenitors induces their proliferation and differentiation into functional dendritic cells. Flores-Romo, L., Björck, P., Duvert, V., van Kooten, C., Saeland, S., Banchereau, J. J. Exp. Med. (1997) [Pubmed]
  24. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. Kögler, G., Sensken, S., Airey, J.A., Trapp, T., Müschen, M., Feldhahn, N., Liedtke, S., Sorg, R.V., Fischer, J., Rosenbaum, C., Greschat, S., Knipper, A., Bender, J., Degistirici, O., Gao, J., Caplan, A.I., Colletti, E.J., Almeida-Porada, G., Müller, H.W., Zanjani, E., Wernet, P. J. Exp. Med. (2004) [Pubmed]
  25. Studies on a new lymphocyte mitogen from Bordetella pertussis. I. Induction of proliferation and polyclonal antibody formation. Ho, M.K., Morse, S.I., Kong, A.S. J. Exp. Med. (1981) [Pubmed]
  26. CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells. Greaves, D.R., Wang, W., Dairaghi, D.J., Dieu, M.C., Saint-Vis, B., Franz-Bacon, K., Rossi, D., Caux, C., McClanahan, T., Gordon, S., Zlotnik, A., Schall, T.J. J. Exp. Med. (1997) [Pubmed]
  27. Establishment of long-term monocyte suspension cultures from normal human peripheral blood. Salahuddin, S.Z., Markham, P.D., Gallo, R.C. J. Exp. Med. (1982) [Pubmed]
  28. Human fetal serum cortisol levels at delivery: a review. Murphy, B.E. Endocr. Rev. (1983) [Pubmed]
  29. Effects of chronic fetal hyperglycemia upon oxygen consumption in the ovine uterus and conceptus. Philipps, A.F., Porte, P.J., Stabinsky, S., Rosenkrantz, T.S., Raye, J.R. J. Clin. Invest. (1984) [Pubmed]
  30. Glucocorticoid levels in maternal and cord serum after prenatal betamethasone therapy to prevent respiratory distress syndrome. Ballard, P.L., Granberg, P., Ballard, R.A. J. Clin. Invest. (1975) [Pubmed]
  31. Circulating 3,3', 5'-triiodothyronine (reverse T3) in the human newborn. Chopra, I.J., Sack, J., Fisher, D.A. J. Clin. Invest. (1975) [Pubmed]
  32. Production of 1,25-dihydroxyvitamin D3 by human T cell lymphotrophic virus-I-transformed lymphocytes. Fetchick, D.A., Bertolini, D.R., Sarin, P.S., Weintraub, S.T., Mundy, G.R., Dunn, J.F. J. Clin. Invest. (1986) [Pubmed]
  33. T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. Ochi, H., Hirani, W.M., Yuan, Q., Friend, D.S., Austen, K.F., Boyce, J.A. J. Exp. Med. (1999) [Pubmed]
  34. Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice. Hogan, C.J., Shpall, E.J., Keller, G. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  35. Interleukin-4 has basophilic and eosinophilic cell growth-promoting activity on cord blood cells. Favre, C., Saeland, S., Caux, C., Duvert, V., De Vries, J.E. Blood (1990) [Pubmed]
  36. Effect of allergen avoidance on development of allergic disorders in infancy. Arshad, S.H., Matthews, S., Gant, C., Hide, D.W. Lancet (1992) [Pubmed]
  37. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Mori, H., Colman, S.M., Xiao, Z., Ford, A.M., Healy, L.E., Donaldson, C., Hows, J.M., Navarrete, C., Greaves, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  38. Development of human mast cells from umbilical cord blood cells by recombinant human and murine c-kit ligand. Mitsui, H., Furitsu, T., Dvorak, A.M., Irani, A.M., Schwartz, L.B., Inagaki, N., Takei, M., Ishizaka, K., Zsebo, K.M., Gillis, S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  39. Human embryonic zeta-globin chains in fetal and newborn blood. Chui, D.H., Mentzer, W.C., Patterson, M., Iarocci, T.A., Embury, S.H., Perrine, S.P., Mibashan, R.S., Higgs, D.R. Blood (1989) [Pubmed]
  40. A cell surface marker gene transferred with a retroviral vector into CD34+ cord blood cells is expressed by their T-cell progeny in the SCID-hu thymus. Champseix, C., Maréchal, V., Khazaal, I., Schwartz, O., Fournier, S., Schlegel, N., Dranoff, G., Danos, O., Blot, P., Vilmer, E., Heard, J.M., Péault, B., Lehn, P. Blood (1996) [Pubmed]
WikiGenes - Universities