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Chemical Compound Review:

Antibiotic TA (12E)-16-ethyl-6,8,9- trihydroxy-12...

Synonyms: AC1O5PV1, 60616-99-1, Myxococcus xanthus antibiotic TA

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Disease relevance of Myxococcus xanthus antibiotic TA

The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase [1].
Effect of adhesive antibiotic TA on plaque and gingivitis in man [2].
Effect of the adhesive antibiotic TA on adhesion and initial growth of E. coli on silicone rubber [3].

High impact information on Myxococcus xanthus antibiotic TA

The polyketide antibiotic TA is synthesized by the Gram negative bacterium Myxococcus xanthus in a multi-step process in which a unique glycine-derived molecule is used as a starter unit and elongated through the condensation of 11 acetate molecules by polyketide synthases (PKSs) [1].
Transposition of TnV and Tn5lac into Myxococcus xanthus yielded 8,381 kanamycin-resistant mutants that were tested for antibiotic TA production [4].
Cloning and characterization of a Myxococcus xanthus cytochrome P-450 hydroxylase required for biosynthesis of the polyketide antibiotic TA [5].
A nonessential signal peptidase II (Lsp) of Myxococcus xanthus might be involved in biosynthesis of the polyketide antibiotic TA [6].
It has been mapped to the antibiotic TA gene cluster, and the disrupted mutants do not produce the antibiotic, indicating a probable involvement in TA production [6].

Biological context of Myxococcus xanthus antibiotic TA

Antibiotic TA was split into two fragments by alkaline hydrolysis followed by periodate oxidation [7].

Gene context of Myxococcus xanthus antibiotic TA

The antibiotic TA of Myxococcus xanthus is a complex macrocyclic polyketide, produced through successive condensations of acetate by a type I PKS (polyketide synthase) mechanism [8].
In this study, we describe the genetic analysis of taK, encoding a specific polyketide beta-ketoacyl:acyl carrier protein synthase, which contains an unusual beta-ketoacyl synthase and acyltransferase motifs and is likely to be involved in antibiotic TA post-modification [9].
The mac-1 gene of Myxococcus xanthus TA, an antibiotic TA producer, encoded a protein with strong sequence similarity to the antibiotic ATP-binding cassette (ABC) transporter for macrolide antibiotics [10].

Analytical, diagnostic and therapeutic context of Myxococcus xanthus antibiotic TA

The adhesive antibiotic TA was applied to the dento-gingival junction of 8 human volunteers, suffering from moderate to severe gingivitis [2].

References

The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase. Paitan, Y., Alon, G., Orr, E., Ron, E.Z., Rosenberg, E. J. Mol. Biol. (1999) [Pubmed]
Effect of adhesive antibiotic TA on plaque and gingivitis in man. Manor, A., Eli, I., Varon, M., Judes, H., Rosenberg, E. Journal of clinical periodontology. (1989) [Pubmed]
Effect of the adhesive antibiotic TA on adhesion and initial growth of E. coli on silicone rubber. Simhi, E., van der Mei, H.C., Ron, E.Z., Rosenberg, E., Busscher, H.J. FEMS Microbiol. Lett. (2000) [Pubmed]
Mutation and mapping of genes involved in production of the antibiotic TA in Myxococcus xanthus. Varon, M., Fuchs, N., Monosov, M., Tolchinsky, S., Rosenberg, E. Antimicrob. Agents Chemother. (1992) [Pubmed]
Cloning and characterization of a Myxococcus xanthus cytochrome P-450 hydroxylase required for biosynthesis of the polyketide antibiotic TA. Paitan, Y., Orr, E., Ron, E.Z., Rosenberg, E. Gene (1999) [Pubmed]
A nonessential signal peptidase II (Lsp) of Myxococcus xanthus might be involved in biosynthesis of the polyketide antibiotic TA. Paitan, Y., Orr, E., Ron, E.Z., Rosenberg, E. J. Bacteriol. (1999) [Pubmed]
Amino acid precursors of Myxococcus xanthus antibiotic TA. Fytlovitch, S., Nathan, P.D., Zafriri, D., Rosenberg, E. J. Antibiot. (1983) [Pubmed]
Genetic and functional analysis of genes required for the post-modification of the polyketide antibiotic TA of Myxococcus xanthus. Paitan, Y., Orr, E., Ron, E.Z., Rosenberg, E. Microbiology (Reading, Engl.) (1999) [Pubmed]
An unusual beta-ketoacyl:acyl carrier protein synthase and acyltransferase motifs in TaK, a putative protein required for biosynthesis of the antibiotic TA in Myxococcus xanthus. Paitan, Y., Orr, E., Ron, E.Z., Rosenberg, E. FEMS Microbiol. Lett. (2001) [Pubmed]
Characterization of the mac-1 gene encoding a putative ABC transporter from Myxococcus xanthus. Kimura, Y., Yamanishi, Y., Tokumasu, Y., Terasaka, H., Yoshinobu, J. J. Biochem. (2001) [Pubmed]

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