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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Myxococcus


Psychiatry related information on Myxococcus


High impact information on Myxococcus


Chemical compound and disease context of Myxococcus


Biological context of Myxococcus

  • The Gram-negative bacterium Myxococcus xanthus has a complex life cycle during which large amounts of a protein of relative molecular mass (Mr) 19,000, known as protein S, are assembled into a spore surface coat by a process that specifically requires calcium ions [16].
  • Tandem repeat of the genes for protein S, a development-specific protein of Myxococcus xanthus [17].
  • Disruption of the Myxococcus xanthus socE gene bypasses the requirement for the cell contact-dependent C-signalling system mediated by CsgA and restores fruiting body morphogenesis and spore differentiation [18].
  • We describe an unusual hybrid histidine protein kinase, which is important for spatially coupling cell aggregation and sporulation during fruiting body formation in Myxococcus xanthus [19].
  • Previously, it was found that the activity of Myxococcus xanthus PFK increased 2.7-fold upon phosphorylation at Thr-226 by the Ser/Thr kinase Pkn4 [20].

Gene context of Myxococcus


Analytical, diagnostic and therapeutic context of Myxococcus


  1. A R59W mutation in human protoporphyrinogen oxidase results in decreased enzyme activity and is prevalent in South Africans with variegate porphyria. Meissner, P.N., Dailey, T.A., Hift, R.J., Ziman, M., Corrigall, A.V., Roberts, A.G., Meissner, D.M., Kirsch, R.E., Dailey, H.A. Nat. Genet. (1996) [Pubmed]
  2. Characterization of nucleoside-diphosphate kinase from Pseudomonas aeruginosa: complex formation with succinyl-CoA synthetase. Kavanaugh-Black, A., Connolly, D.M., Chugani, S.A., Chakrabarty, A.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. FrzE of Myxococcus xanthus is homologous to both CheA and CheY of Salmonella typhimurium. McCleary, W.R., Zusman, D.R. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. Identification and characterization of FrzZ, a novel response regulator necessary for swarming and fruiting-body formation in Myxococcus xanthus. Trudeau, K.G., Ward, M.J., Zusman, D.R. Mol. Microbiol. (1996) [Pubmed]
  5. Bacteriophage MX-1: properties of the phage and its structural proteins. Tsopanakis, C., Parish, J.H. J. Gen. Virol. (1976) [Pubmed]
  6. Inhibition of cell-cell interactions in Myxococcus xanthus by congo red. Arnold, J.W., Shimkets, L.J. J. Bacteriol. (1988) [Pubmed]
  7. Reverse transcriptase with concomitant ribonuclease H activity in the cell-free synthesis of branched RNA-linked msDNA of Myxococcus xanthus. Lampson, B.C., Inouye, M., Inouye, S. Cell (1989) [Pubmed]
  8. A bacterial calcium-binding protein homologous to calmodulin. Swan, D.G., Hale, R.S., Dhillon, N., Leadlay, P.F. Nature (1987) [Pubmed]
  9. The guanosine nucleotide (p)ppGpp initiates development and A-factor production in myxococcus xanthus. Harris, B.Z., Kaiser, D., Singer, M. Genes Dev. (1998) [Pubmed]
  10. Programmed death in bacteria. Lewis, K. Microbiol. Mol. Biol. Rev. (2000) [Pubmed]
  11. Growth phase dependence of the activation of a bacterial gene for carotenoid synthesis by blue light. Fontes, M., Ruiz-Vázquez, R., Murillo, F.J. EMBO J. (1993) [Pubmed]
  12. Construction of Tn5 lac, a transposon that fuses lacZ expression to exogenous promoters, and its introduction into Myxococcus xanthus. Kroos, L., Kaiser, D. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  13. Identification of a gene involved in polysaccharide export as a transcription target of FruA, an essential factor for Myxococcus xanthus development. Ueki, T., Inouye, S. J. Biol. Chem. (2005) [Pubmed]
  14. An inhibitor of mitochondrial respiration which binds to cytochrome b and displaces quinone from the iron-sulfur protein of the cytochrome bc1 complex. von Jagow, G., Ljungdahl, P.O., Graf, P., Ohnishi, T., Trumpower, B.L. J. Biol. Chem. (1984) [Pubmed]
  15. Identification of an FAD superfamily containing protoporphyrinogen oxidases, monoamine oxidases, and phytoene desaturase. Expression and characterization of phytoene desaturase of Myxococcus xanthus. Dailey, T.A., Dailey, H.A. J. Biol. Chem. (1998) [Pubmed]
  16. Myxococcus xanthus spore coat protein S may have a similar structure to vertebrate lens beta gamma-crystallins. Wistow, G., Summers, L., Blundell, T. Nature (1985) [Pubmed]
  17. Tandem repeat of the genes for protein S, a development-specific protein of Myxococcus xanthus. Inouye, S., Ike, Y., Inouye, M. J. Biol. Chem. (1983) [Pubmed]
  18. The Myxococcus xanthus socE and csgA genes are regulated by the stringent response. Crawford, E.W., Shimkets, L.J. Mol. Microbiol. (2000) [Pubmed]
  19. Coupling of multicellular morphogenesis and cellular differentiation by an unusual hybrid histidine protein kinase in Myxococcus xanthus. Rasmussen, A.A., Porter, S.L., Armitage, J.P., Søgaard-Andersen, L. Mol. Microbiol. (2005) [Pubmed]
  20. An effective sporulation of Myxococcus xanthus requires glycogen consumption via Pkn4-activated 6-phosphofructokinase. Nariya, H., Inouye, S. Mol. Microbiol. (2003) [Pubmed]
  21. PIM1 encodes a mitochondrial ATP-dependent protease that is required for mitochondrial function in the yeast Saccharomyces cerevisiae. Van Dyck, L., Pearce, D.A., Sherman, F. J. Biol. Chem. (1994) [Pubmed]
  22. GidA is an FAD-binding protein involved in development of Myxococcus xanthus. White, D.J., Merod, R., Thomasson, B., Hartzell, P.L. Mol. Microbiol. (2001) [Pubmed]
  23. Identification and characterization of the Myxococcus xanthus argE gene. Harris, B.Z., Singer, M. J. Bacteriol. (1998) [Pubmed]
  24. Characterization of calcium-binding sites in development-specific protein S of Myxococcus xanthus using site-specific mutagenesis. Teintze, M., Inouye, M., Inouye, S. J. Biol. Chem. (1988) [Pubmed]
  25. Molecular cloning and characterization of two genes for the biotin carboxylase and carboxyltransferase subunits of acetyl coenzyme A carboxylase in Myxococcus xanthus. Kimura, Y., Miyake, R., Tokumasu, Y., Sato, M. J. Bacteriol. (2000) [Pubmed]
  26. Rhizopodin, a new compound from Myxococcus stipitatus (myxobacteria) causes formation of rhizopodia-like structures in animal cell cultures. Production, isolation, physico-chemical and biological properties. Sasse, F., Steinmetz, H., Höfle, G., Reichenbach, H. J. Antibiot. (1993) [Pubmed]
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