Disease relevance of Myxococcus

• PPO cDNAs from Bacillus subtilis, Myxococcus xanthus, human placenta and mouse liver have been cloned, sequenced and expressed [1].
• The N-terminal 12 amino acid sequence of P. aeruginosa Ndk shows significant homology with that of Myxococcus xanthus and that of Escherichia coli [2].
• FrzE of Myxococcus xanthus is homologous to both CheA and CheY of Salmonella typhimurium [3].
• The frz genes of Myxococcus xanthus constitute a signal-transduction pathway that processes chemotactic information in a manner analogous to that found in enteric bacteria [4].
• Bacteriophage MX-1 is a virulent DNA phage for Myxococcus [5].

Psychiatry related information on Myxococcus

• This strategy was used to examine the function of the major Congo red receptor of the myxobacterium Myxococcus xanthus, which has a developmental cycle that involves social interactions among cells [6].

High impact information on Myxococcus

• Reverse transcriptase with concomitant ribonuclease H activity in the cell-free synthesis of branched RNA-linked msDNA of Myxococcus xanthus [7].
• Protein S from the spore coat of the Gram-negative bacterium Myxococcus xanthus has been shown to resemble calmodulin in its internally-duplicated structure and ability to bind calcium [8].
• Moreover, the wild-type allele of Myxococcus relA rescues DK527 [9].
• The guanosine nucleotide (p)ppGpp initiates development and A-factor production in myxococcus xanthus [9].
• Programmed cell death (PCD) in bacteria plays an important role in developmental processes, such as lysis of the mother cell during sporulation of Bacillus subtilis and lysis of vegetative cells in fruiting body formation of Myxococcus xanthus [10].

Chemical compound and disease context of Myxococcus

• Myxococcus xanthus responds to blue light by producing carotenoid pigments [11].
• A chromogenic substrate of beta-galactosidase, 5-bromo-4-chloro-3-indolyl beta-D-galactoside, is toxic in Myxococcus when cleaved in large amounts [12].
• Identification of a gene involved in polysaccharide export as a transcription target of FruA, an essential factor for Myxococcus xanthus development [13].
• Myxothiazol, an antibiotic from Myxococcus fulvus, which inhibits mitochondrial respiration in the bc1 complex of the respiratory chain, has effects on the redox components of isolated succinate-cytochrome c reductase complex which suggest that it interacts with both cytochrome b and the iron-sulfur protein of the bc1 complex [14].
• We have carried out the expression and purification of PHD from the bacterium Myxococcus xanthus and demonstrate the presence of noncovalently bound FAD [15].

Biological context of Myxococcus

• The Gram-negative bacterium Myxococcus xanthus has a complex life cycle during which large amounts of a protein of relative molecular mass (Mr) 19,000, known as protein S, are assembled into a spore surface coat by a process that specifically requires calcium ions [16].
• Tandem repeat of the genes for protein S, a development-specific protein of Myxococcus xanthus [17].
• Disruption of the Myxococcus xanthus socE gene bypasses the requirement for the cell contact-dependent C-signalling system mediated by CsgA and restores fruiting body morphogenesis and spore differentiation [18].
• We describe an unusual hybrid histidine protein kinase, which is important for spatially coupling cell aggregation and sporulation during fruiting body formation in Myxococcus xanthus [19].
• Previously, it was found that the activity of Myxococcus xanthus PFK increased 2.7-fold upon phosphorylation at Thr-226 by the Ser/Thr kinase Pkn4 [20].

Gene context of Myxococcus

• The PIM1 nuclear gene in the yeast Saccharomyces cerevisiae encodes a mitochondrial ATP-dependent protease that exhibits over 30% identity with ATP-dependent protease La from Escherichia coli, Lon from Bacillus brevis, and one from Myxococcus xanthus [21].
• The Myxococcus xanthus socE and csgA genes are regulated by the stringent response [18].
• An effective sporulation of Myxococcus xanthus requires glycogen consumption via Pkn4-activated 6-phosphofructokinase [20].
• A gene encoding a homologue of the Escherichia coli GidA protein (glucose-inhibited division protein A) lies immediately upstream of aglU, a gene encoding a WD-repeat protein required for motility and development in Myxococcus xanthus [22].
• Identification and characterization of the Myxococcus xanthus argE gene [23].

Analytical, diagnostic and therapeutic context of Myxococcus

• Characterization of calcium-binding sites in development-specific protein S of Myxococcus xanthus using site-specific mutagenesis [24].
• Molecular cloning and characterization of two genes for the biotin carboxylase and carboxyltransferase subunits of acetyl coenzyme A carboxylase in Myxococcus xanthus [25].
• Rhizopodin, a new compound from Myxococcus stipitatus (myxobacteria) causes formation of rhizopodia-like structures in animal cell cultures. Production, isolation, physico-chemical and biological properties [26].

References