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Chemical Compound Review:

Azalomycin-F 3-[[(13E,15E,21E,23E)-19- [(E)-10...

Synonyms: Azalomycin F, LS-22687, AC1O5194, 11003-24-0, Azalomycin F monoacetate

Kuroda, S. et al., Simkovic, M. et al., Simkovic, M. et al., Chandra, A. et al.

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Disease relevance of Azalomycin F

Azalomycin F complex from Streptomyces hygroscopicus, MSU/MN-4-75B [1].

High impact information on Azalomycin F

It was postulated that the sites on the cell membrane sensitive to miconazole and clotrimazole are different from those sensitive to copiamycin and azalomycin F [2].
Both Ca2+ influx and efflux were stimulated by the uncouplers (and the treatment leading to the suppression of energy metabolism) and by azalomycin F, an antifungal agent [3].
The effect of azalomycin F on Ca2+ homeostasis in Trichoderma viride and Saccharomyces cerevisiae [4].

Anatomical context of Azalomycin F

As the antimicrobial activities of copiamycin and azalomycin F were most strongly reversed in the same manner by phospholipids with unsaturated fatty acids and basic hydrophilic groups, the sites on the cell membrane sensitive to both antibiotics are assumed to be identical [2].

References

Azalomycin F complex from Streptomyces hygroscopicus, MSU/MN-4-75B. Chandra, A., Nair, M.G. J. Antibiot. (1995) [Pubmed]
Target substances of some antifungal agents in the cell membrane. Kuroda, S., Uno, J., Arai, T. Antimicrob. Agents Chemother. (1978) [Pubmed]
Ca2+ fluxes in developing Trichoderma viride mycelium. Simkovic, M., Krystofová, S., Varecka, L. Can. J. Microbiol. (2000) [Pubmed]
The effect of azalomycin F on Ca2+ homeostasis in Trichoderma viride and Saccharomyces cerevisiae. Simkovic, M., Lakatos, B., Tsuji, F.I., Muto, S., Varecka, L. Gen. Physiol. Biophys. (2001) [Pubmed]

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