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Chemical Compound Review

Canesten     1-[(2-chlorophenyl)-diphenyl- methyl]imidazole

Synonyms: Kanesten, Lotrimin, Mycelex, Klotrimazole, clotrimazole, ...
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Disease relevance of Mycelex


Psychiatry related information on Mycelex

  • It is concluded that a three-day course of two clotrimazole vaginal tablet daily is as effective and safe as the previously recommended one tablet daily for seven days, and the shorter therapy is likely to improve patient compliance [4].

High impact information on Mycelex


Chemical compound and disease context of Mycelex


Biological context of Mycelex


Anatomical context of Mycelex


Associations of Mycelex with other chemical compounds

  • We conducted a prospective, randomized trial that compared fluconazole (200 mg per day) with clotrimazole troches (10 mg taken five times daily) in patients who were also participating in a randomized trial of primary prophylaxis for Pneumocystis carinii pneumonia [2].
  • Sixty assessable patients were randomized to receive either clotrimazole troches (n = 32) or nystatin oral suspension (n = 28) for a 60-day period after receiving a renal allograft [18].
  • We have investigated in vitro and in vivo the effects of clotrimazole (CLT) and miconazole (MIC) on transgenic mice red cells expressing hemoglobin SAD [19].
  • Single-channel current amplitudes reflected the macroscopic inward rectification and revealed a conductance level of 39 pS in the inward direction. hIK1 currents were reversibly blocked by charybdotoxin (Ki = 2.5 nM) and clotrimazole (Ki = 24.8 nM) but were minimally affected by apamin (100 nM), iberiotoxin (50 nM), or ketoconazole (10 microM) [20].
  • To illustrate this finding, we selected as starting point the biological activity spectra of clotrimazole and tioconazole because their putative target, lanosterol demethylase (CYP51), was not included in the bioassay array [21].

Gene context of Mycelex


Analytical, diagnostic and therapeutic context of Mycelex


  1. Treatment of chronic oral candidiasis with clotrimazole troches. A controlled clinical trial. Kirkpatrick, C.H., Alling, D.W. N. Engl. J. Med. (1978) [Pubmed]
  2. A randomized trial comparing fluconazole with clotrimazole troches for the prevention of fungal infections in patients with advanced human immunodeficiency virus infection. NIAID AIDS Clinical Trials Group. Powderly, W.G., Finkelstein, D., Feinberg, J., Frame, P., He, W., van der Horst, C., Koletar, S.L., Eyster, M.E., Carey, J., Waskin, H. N. Engl. J. Med. (1995) [Pubmed]
  3. A concentrated therapeutic regimen for vulvovaginal candidiasis. Robertson, W.H. JAMA (1980) [Pubmed]
  4. A comparison of a three-day and seven-day clotrimazole regimen for vulvovaginal candidiasis. Lebherz, T.B., Ford, L.C., Kleinkopf, V. Clinical therapeutics. (1981) [Pubmed]
  5. Treating rheumatoid arthritis with clotrimazole. Panayi, G.S. Nat. Med. (1995) [Pubmed]
  6. Clotrimazole inhibits cell proliferation in vitro and in vivo. Benzaquen, L.R., Brugnara, C., Byers, H.R., Gatton-Celli, S., Halperin, J.A. Nat. Med. (1995) [Pubmed]
  7. Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a beta thalassemic mouse: a model for human therapy. de Franceschi, L., Rouyer-Fessard, P., Alper, S.L., Jouault, H., Brugnara, C., Beuzard, Y. Blood (1996) [Pubmed]
  8. Transcriptional regulation of rat microsomal epoxide hydrolase gene by imidazole antimycotic agents. Kim, S.G. Mol. Pharmacol. (1992) [Pubmed]
  9. Tumor apoptosis induced by ruthenium(II)-ketoconazole is enhanced in nonsusceptible carcinoma by monoclonal antibody to EGF receptor. Strasberg Rieber, M., Anzellotti, A., Sánchez-Delgado, R.A., Rieber, M. Int. J. Cancer (2004) [Pubmed]
  10. Clotrimazole: a review of its antifungal activity and therapeutic efficacy. Sawyer, P.R., Brogden, R.N., Pinder, R.M., Speight, T.M., Avery, n.u.l.l. Drugs (1975) [Pubmed]
  11. Placebo-controlled trial of itraconazole for treatment of acute vaginal candidiasis. Stein, G.E., Mummaw, N. Antimicrob. Agents Chemother. (1993) [Pubmed]
  12. Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. Makita, K., Takahashi, K., Karara, A., Jacobson, H.R., Falck, J.R., Capdevila, J.H. J. Clin. Invest. (1994) [Pubmed]
  13. Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole. Aktas, H., Flückiger, R., Acosta, J.A., Savage, J.M., Palakurthi, S.S., Halperin, J.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  14. Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis. De Franceschi, L., Rivera, A., Fleming, M.D., Honczarenko, M., Peters, L.L., Gascard, P., Mohandas, N., Brugnara, C. Blood (2005) [Pubmed]
  15. Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. Brugnara, C., Gee, B., Armsby, C.C., Kurth, S., Sakamoto, M., Rifai, N., Alper, S.L., Platt, O.S. J. Clin. Invest. (1996) [Pubmed]
  16. The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells. Rufo, P.A., Jiang, L., Moe, S.J., Brugnara, C., Alper, S.L., Lencer, W.I. J. Clin. Invest. (1996) [Pubmed]
  17. The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera. Rufo, P.A., Merlin, D., Riegler, M., Ferguson-Maltzman, M.H., Dickinson, B.L., Brugnara, C., Alper, S.L., Lencer, W.I. J. Clin. Invest. (1997) [Pubmed]
  18. A comparative trial of clotrimazole troches and oral nystatin suspension in recipients of renal transplants. Use in prophylaxis of oropharyngeal candidiasis. Gombert, M.E., duBouchet, L., Aulicino, T.M., Butt, K.M. JAMA (1987) [Pubmed]
  19. Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease. De Franceschi, L., Saadane, N., Trudel, M., Alper, S.L., Brugnara, C., Beuzard, Y. J. Clin. Invest. (1994) [Pubmed]
  20. A human intermediate conductance calcium-activated potassium channel. Ishii, T.M., Silvia, C., Hirschberg, B., Bond, C.T., Adelman, J.P., Maylie, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  21. Biological spectra analysis: Linking biological activity profiles to molecular structure. Fliri, A.F., Loging, W.T., Thadeio, P.F., Volkmann, R.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  22. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. Moore, L.B., Parks, D.J., Jones, S.A., Bledsoe, R.K., Consler, T.G., Stimmel, J.B., Goodwin, B., Liddle, C., Blanchard, S.G., Willson, T.M., Collins, J.L., Kliewer, S.A. J. Biol. Chem. (2000) [Pubmed]
  23. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Schuetz, E.G., Beck, W.T., Schuetz, J.D. Mol. Pharmacol. (1996) [Pubmed]
  24. Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes. Wang, H., Faucette, S.R., Gilbert, D., Jolley, S.L., Sueyoshi, T., Negishi, M., LeCluyse, E.L. Drug Metab. Dispos. (2003) [Pubmed]
  25. The xenobiotic inhibitor profile of cytochrome P4502C8. Ong, C.E., Coulter, S., Birkett, D.J., Bhasker, C.R., Miners, J.O. British journal of clinical pharmacology. (2000) [Pubmed]
  26. Efficacy of human salivary mucin MUC7-derived peptide and histatin 5 in a murine model of candidiasis. Intini, G., Aguirre, A., Bobek, L.A. Int. J. Antimicrob. Agents (2003) [Pubmed]
  27. Prophylaxis of oropharyngeal candidiasis with clotrimazole. Yeo, E., Alvarado, T., Fainstein, V., Bodey, G.P. J. Clin. Oncol. (1985) [Pubmed]
  28. Expression, purification, and spectroscopic characterization of human thromboxane synthase. Hsu, P.Y., Tsai, A.L., Kulmacz, R.J., Wang, L.H. J. Biol. Chem. (1999) [Pubmed]
  29. Clotrimazole treatment for prevention of oral candidiasis in patients with acute leukemia undergoing chemotherapy. Results of a double-blind study. Cuttner, J., Troy, K.M., Funaro, L., Brenden, R., Bottone, E.J. Am. J. Med. (1986) [Pubmed]
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