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Chemical Compound Review:

Streptovirudin (E)-N-[(2S,3R,4R,5R,6R)-2- [(3S,4S,5R,6S)-3...

Synonyms: AC1O51G1, 56833-74-0

Thrum, H. et al., Tonew, E. et al., Keenan, R.W. et al., Tonew, E. et al., Eckardt, K. et al., et al.

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Disease relevance of Streptovirudin

Streptovirudin inhibits glycosylation and multiplication of vesicular stomatitis virus [1].
Streptovirudin is a complex of antibiotics isolated from fermentation of a Streptomyces strain [2].
It is a white amorphous material which consists of ten closely related components including streptovirudins A, B, C, D and E. The streptovirudin complex exhibits antibiotic activity against Gram-positive bacteria, mycobacteria, and various DNA- and RNA-viruses [3].
Effect of streptovirudin on parainfluenza 3 virus multiplication [4].
Effects of streptovirudin on influenza viruses type A and B: inhibition of the lipid-linked oligosaccharide synthesis of fowl plague virus [5].

High impact information on Streptovirudin

The nucleoside antibiotics tunicamycin and streptovirudin were separated by high-performance liquid chromatography into a series of 256-nm-absorbing peaks [6].

Analytical, diagnostic and therapeutic context of Streptovirudin

The naturally formed streptovirudin complex, in concentrations of 20-2.5 mug/ml inhibited the viral cytopathic effect and caused 100 percent plaque reduction [7].

References

Streptovirudin inhibits glycosylation and multiplication of vesicular stomatitis virus. Kang, M.S., Park, J.J., Singh, I., Phillips, L.A. Biochem. Biophys. Res. Commun. (1981) [Pubmed]
Streptovirudins, new antibiotics with antibacterial and antiviral activity. II. Isolation, chemical characterization and biological activity of streptovirudins A1, A2, B1, B2, C1, C2, D1, and D2. Eckardt, K., Thrum, H., Bradler, G., Tonew, E., Tonew, M. J. Antibiot. (1975) [Pubmed]
Streptovirudins, new antibiotics with antibacterial and antiviral activity. I. Culture taxonomy, fermentation and production of streptovirudin complex. Thrum, H., Eckardt, K., Bradler, G., Fügner, R., Tonew, E., Tonew, M. J. Antibiot. (1975) [Pubmed]
Effect of streptovirudin on parainfluenza 3 virus multiplication. Dobus, M., Korbecki, M., Szmigielski, S., Rytko, J. Acta Virol. (1977) [Pubmed]
Effects of streptovirudin on influenza viruses type A and B: inhibition of the lipid-linked oligosaccharide synthesis of fowl plague virus. Tonew, E., Tonew, M., Indulen, M.K., Dzeguze, D.R. Acta Virol. (1982) [Pubmed]
Biological activities of isolated tunicamycin and streptovirudin fractions. Keenan, R.W., Hamill, R.L., Occolowitz, J.L., Elbein, A.D. Biochemistry (1981) [Pubmed]
Streptovirudins -- new antibiotics with antiviral activity. The antiviral spectrum and inhibition of Newcastle disease virus in cell cultures. Tonew, E., Tonew, M., Eckardt, K., Thrum, H., Gumpert, B. Acta Virol. (1975) [Pubmed]

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