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MeSH Review

Cytopathogenic Effect, Viral

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  • The serine proteinase inhibitor (serpin) plasminogen activation inhibitor type 2 protects against viral cytopathic effects by constitutive interferon alpha/beta priming [4].
  • The results indicated that both acyclovir and TFT were ineffective in inhibiting viral cytopathic effect (CPE) below the concentration of 50 microM [5].
  • S-phase infection also produced a delay in the appearance of the viral cytopathic effect and in the synthesis of immediate-early and early proteins [6].
  • Cells infected with TK virus have an uptake of IdC similar to that of uninfected cells, whereas cells infected with TK+ generally have an uptake greater than 10 times that of uninfected cells if tested when obvious viral cytopathic effect is present [7].
  • Post-shock increases in viral fusion (F) gene transcripts and F protein were associated with dramatic increases in viral cytopathic effect [8].

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Associations of Cytopathogenic Effect, Viral with chemical compounds


Gene context of Cytopathogenic Effect, Viral

  • The antiviral action of recombinant human tumor necrosis factor (TNF) was studied using assay systems to determine inhibition of viral cytopathic effect (CPE), as well as suppression of virus growth measured by plaque assays [14].
  • Our conclusions follow: (1) The milder form of SARS in children and the apparent protective factor that immunosupression represent rules out a significant viral cytopathic effect (they would be the most affected) [15].
  • It is concluded that the NS-2 protein has little cytotoxic activity by itself but is required for the full expression of the viral cytopathic effect on transformed human cells [16].


  1. Human immunodeficiency virus type 1 Vpu modifies viral cytopathic effect through augmented virus release. Iwatani, Y., Song, S.K., Wang, L., Planas, J., Sakai, H., Ishimoto, A., Cloyd, M.W. J. Gen. Virol. (1997) [Pubmed]
  2. Nef 27, but not the Nef 25 isoform of human immunodeficiency virus-type 1 pNL4.3 down-regulates surface CD4 and IL-2R expression in peripheral blood mononuclear cells and transformed T cells. Greenway, A.L., McPhee, D.A., Grgacic, E., Hewish, D., Lucantoni, A., Macreadie, I., Azad, A. Virology (1994) [Pubmed]
  3. Herpes simplex virus type 1 replication and IL-1 beta gene expression in mouse peritoneal macrophages activated in vivo by an attenuated Salmonella typhimurium vaccine or Corynebacterium parvum. Wu, L., Morahan, P.S., Hendrzak, J.A., Eisenstein, T.K. Microb. Pathog. (1994) [Pubmed]
  4. The serine proteinase inhibitor (serpin) plasminogen activation inhibitor type 2 protects against viral cytopathic effects by constitutive interferon alpha/beta priming. Antalis, T.M., La Linn, M., Donnan, K., Mateo, L., Gardner, J., Dickinson, J.L., Buttigieg, K., Suhrbier, A. J. Exp. Med. (1998) [Pubmed]
  5. Effectiveness of acycloguanosine and trifluorothymidine as inhibitors of cytomegalovirus infection in vitro. Lang, D.J., Cheung, K.S. Am. J. Med. (1982) [Pubmed]
  6. Cell cycle dysregulation by human cytomegalovirus: influence of the cell cycle phase at the time of infection and effects on cyclin transcription. Salvant, B.S., Fortunato, E.A., Spector, D.H. J. Virol. (1998) [Pubmed]
  7. Uptake of [125I]iododeoxycytidine by cells infected with herpes simplex virus: a rapid screening test for resistance to acyclovir. Van Dyke, R.B., Connor, J.D. J. Infect. Dis. (1985) [Pubmed]
  8. Enhanced production of morbillivirus gene-specific RNAs following induction of the cellular stress response in stable persistent infection. Oglesbee, M.J., Kenney, H., Kenney, T., Krakowka, S. Virology (1993) [Pubmed]
  9. A polymorphism in the poliovirus receptor gene differs in motor neuron disease. Saunderson, R., Yu, B., Trent, R.J., Pamphlett, R. Neuroreport (2004) [Pubmed]
  10. Inhibition of in vitro HIV infection by trinitrophenyl-protein conjugates. Matsiota-Bernard, P., Guetard, D., Rame, V., Montagnier, L., Avrameas, S. Res. Immunol. (1995) [Pubmed]
  11. Inhibition of the multiplication of enveloped and non-enveloped viruses by glucosamine. Delgadillo, R.A., Vanden Berghe, D.A. J. Pharm. Pharmacol. (1988) [Pubmed]
  12. In vitro antiviral efficacy of ribavirin against feline calicivirus, feline viral rhinotracheitis virus, and canine parainfluenza virus. Povey, R.C. Am. J. Vet. Res. (1978) [Pubmed]
  13. Streptovirudins -- new antibiotics with antiviral activity. The antiviral spectrum and inhibition of Newcastle disease virus in cell cultures. Tonew, E., Tonew, M., Eckardt, K., Thrum, H., Gumpert, B. Acta Virol. (1975) [Pubmed]
  14. Antiviral effects of recombinant human tumor necrosis factor. Ito, M., O'Malley, J.A. Lymphokine Res. (1987) [Pubmed]
  15. Severe acute respiratory syndrome, a pathological immune response to the new coronavirus--implications for understanding of pathogenesis, therapy, design of vaccines, and epidemiology. Bermejo, J.F., Muñoz-Fernandez, M.A. Viral Immunol. (2004) [Pubmed]
  16. MVM(p) NS-2 protein expression is required with NS-1 for maximal cytotoxicity in human transformed cells. Legrand, C., Rommelaere, J., Caillet-Fauquet, P. Virology (1993) [Pubmed]
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