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Chemical Compound Review

AC1O5390     (2R,3S,4R,5R)-5,6-dihydroxy- 2,3,4...

Synonyms: 38819-02-2
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Disease relevance of Cellopentaose


High impact information on Cellopentaose

  • The kinetics of cellopentaose binding to BglH was investigated using the carbohydrate-induced current noise and was compared with that of cellopentaose binding to LamB (maltoporin) and ScrY (sucroseporin) [3].
  • The unhydrolysed cellopentaose and the G2SG2 cello-oligomers span the active site of the catalytically active H.grisea Cel12A enzyme, with the pyranoside bound in subsite -1 displaying a S31 skew boat conformation [4].
  • DSC thermograms of the unfolding of CBDN1 in the presence of various concentrations of cellopentaose were fit to a thermodynamic model describing the linkage between protein-ligand binding and protein unfolding [5].
  • We describe a new nonradioactive technique for determining substrate specificity, in which ion-spray mass spectrometry was used to analyze the products of enzymatic digests of cellopentaose labeled with 18O at the reducing end [6].
  • Isothermal titration calorimetric studies showed that the association constants (K(a)) of the CBM polypeptide (CBM30) for the binding of cellopentaose and cellohexaose were 1.2 x 10(4) and 6.4 x 10(4) M(-1), respectively, and that the binding of CBM30 to these ligands is enthalpically driven [7].

Biological context of Cellopentaose

  • The cleavage pattern of p-nitrophenyl beta-D-cellotetraoside, blockage of the hydrolysis of NaBH(4)-reduced cellopentaose and the reduction in substrate viscosity suggested activity from the reducing end in a processive mode after making random cuts [8].

Associations of Cellopentaose with other chemical compounds


  1. Atomic (0.94 A) resolution structure of an inverting glycosidase in complex with substrate. Guérin, D.M., Lascombe, M.B., Costabel, M., Souchon, H., Lamzin, V., Béguin, P., Alzari, P.M. J. Mol. Biol. (2002) [Pubmed]
  2. Simultaneous high-performance liquid chromatographic determination of both the cleavage pattern and the stereochemical outcome of the hydrolysis reactions catalyzed by various glycosidases. Braun, C., Meinke, A., Ziser, L., Withers, S.G. Anal. Biochem. (1993) [Pubmed]
  3. The gene bglH present in the bgl operon of Escherichia coli, responsible for uptake and fermentation of beta-glucosides encodes for a carbohydrate-specific outer membrane porin. Andersen, C., Rak, B., Benz, R. Mol. Microbiol. (1999) [Pubmed]
  4. Crystal complex structures reveal how substrate is bound in the -4 to the +2 binding sites of Humicola grisea Cel12A. Sandgren, M., Berglund, G.I., Shaw, A., Ståhlberg, J., Kenne, L., Desmet, T., Mitchinson, C. J. Mol. Biol. (2004) [Pubmed]
  5. Stability and oligosaccharide binding of the N1 cellulose-binding domain of Cellulomonas fimi endoglucanase CenC. Creagh, A.L., Koska, J., Johnson, P.E., Tomme, P., Joshi, M.D., McIntosh, L.P., Kilburn, D.G., Haynes, C.A. Biochemistry (1998) [Pubmed]
  6. Identification of two functionally different classes of exocellulases. Barr, B.K., Hsieh, Y.L., Ganem, B., Wilson, D.B. Biochemistry (1996) [Pubmed]
  7. Characterization of a cellulase containing a family 30 carbohydrate-binding module (CBM) derived from Clostridium thermocellum CelJ: importance of the CBM to cellulose hydrolysis. Arai, T., Araki, R., Tanaka, A., Karita, S., Kimura, T., Sakka, K., Ohmiya, K. J. Bacteriol. (2003) [Pubmed]
  8. A newly described cellulosomal cellobiohydrolase, CelO, from Clostridium thermocellum: investigation of the exo-mode of hydrolysis, and binding capacity to crystalline cellulose. Zverlov, V.V., Velikodvorskaya, G.A., Schwarz, W.H. Microbiology (Reading, Engl.) (2002) [Pubmed]
  9. Expression and Purification of Cellulase Xf818 from Xylella fastidiosa in Escherichia coli. Wulff, N.A., Carrer, H., Pascholati, S.F. Curr. Microbiol. (2006) [Pubmed]
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