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Chemical Compound Review:

SureCN1331548 1-[ (3R,5R,8R,9R,10S,11S,13S,14S,1 7S)-3,11...

Synonyms: LMST02030100, ZINC04096762, AC1L23H7, C05476, 68-42-8, ...

Vogt, B. et al., Soro, A. et al., Imperato-McGinley, J. et al., Ackermann, D. et al., Kohl, K.H. et al.

Vogt, Dick, Marti, Frey, Frey,

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Disease relevance of C05476

METHODS: We assessed the 11beta-HSD activity by measuring the urinary ratio of tetrahydrocorticosterone (THB) plus 5alpha-tetrahydrocorticosterone (5alpha-THB) to 11-dehydro-tetrahydrocorticosterone (THA) by gas chromatography-mass spectrometry in rats with puromycin aminonucleoside (PAN)-induced proteinuria and with adriamycin nephrosis [1].
In a large group of patients with untreated hypertension, excretion rates of tetrahydrocorticosterone (THB), allotetrahydrocorticosterone (alloTHB) and tetrahydro-11-dehydrocorticosterone (THA) were all significantly higher than in a group of matched normotensive controls [2].

High impact information on C05476

In men, the highest index of discrimination of the carrier state was the tetrahydrocorticosterone/allotetrahydrocorticosterone ratio, while in women, the etiocholanolone/androsterone ratio was more diagnostic [3].

Analytical, diagnostic and therapeutic context of C05476

The urinary ratio of (tetrahydrocorticosterone + 5alpha-tetrahydrocorticosterone)/ 11-dehydro-tetrahydrocorticosterone [(THB+5alpha-THB)/THA] was measured by gas chromatography [4].
Radioimmunoassay of tetrahydrocorticosterone (THB) in human urine [5].

References

Reduced 11beta-hydroxysteroid dehydrogenase activity in experimental nephrotic syndrome. Vogt, B., Dick, B., Marti, H.P., Frey, F.J., Frey, B.M. Nephrol. Dial. Transplant. (2002) [Pubmed]
Mildly raised corticosterone excretion rates in patients with essential hypertension. Soro, A., Ingram, M.C., Tonolo, G., Glorioso, N., Fraser, R. Journal of human hypertension. (1995) [Pubmed]
Decreased urinary C19 and C21 steroid 5 alpha-metabolites in parents of male pseudohermaphrodites with 5 alpha-reductase deficiency: detection of carriers. Imperato-McGinley, J., Peterson, R.E., Gautier, T., Arthur, A., Shackleton, C. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
Inhibition of 11beta-hydroxysteroid dehydrogenase by bile acids in rats with cirrhosis. Ackermann, D., Vogt, B., Escher, G., Dick, B., Reichen, J., Frey, B.M., Frey, F.J. Hepatology (1999) [Pubmed]
Radioimmunoassay of tetrahydrocorticosterone (THB) in human urine. Kohl, K.H., Abdelhamid, S., Penke, B., Vecsei, P. Acta Endocrinol. (1978) [Pubmed]

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