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MeSH Review


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Disease relevance of Nephrosis


High impact information on Nephrosis


Chemical compound and disease context of Nephrosis

  • The effects of experimental nephrosis in rats, produced by puromycin aminonucleoside, include an elevation of plasma levels of all lipoprotein density classes and the appearance of high density lipoprotein (HDL) rich in apoprotein (apo) A-I and deficient in apo A-IV and apo E [11].
  • Dynamics of renal histamine in normal rat kidney and in nephrosis induced by aminonucleoside of puromycin [12].
  • Localization of sialic acid in kidney glomeruli: regionalization in the podocyte plasma membrane and loss in experimental nephrosis [13].
  • Irreversible tubulointerstitial damage associated with chronic aminonucleoside nephrosis. Amelioration by angiotensin I converting enzyme inhibition [14].
  • This study shows that maneuvers that modulate the glomerular macrophage number are also associated with corresponding changes in the number of proliferating cells within the mesangium, suggesting a paracrine growth stimulation by the infiltrating macrophage during acute PA nephrosis [15].

Biological context of Nephrosis


Anatomical context of Nephrosis


Gene context of Nephrosis


Analytical, diagnostic and therapeutic context of Nephrosis


  1. Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. Remuzzi, G., Imberti, L., Rossini, M., Morelli, C., Carminati, C., Cattaneo, G.M., Bertani, T. J. Clin. Invest. (1985) [Pubmed]
  2. Severe steroid-responsive nephrosis associated with hypersensitivity. Sandberg, D.H., Bernstein, C.W., McIntosh, R.M., Carr, R., Strauss, J. Lancet (1977) [Pubmed]
  3. Mapping a gene (SRN1) to chromosome 1q25-q31 in idiopathic nephrotic syndrome confirms a distinct entity of autosomal recessive nephrosis. Fuchshuber, A., Jean, G., Gribouval, O., Gubler, M.C., Broyer, M., Beckmann, J.S., Niaudet, P., Antignac, C. Hum. Mol. Genet. (1995) [Pubmed]
  4. Chemokine expression in experimental tubulointerstitial nephritis. Tang, W.W., Qi, M., Warren, J.S., Van, G.Y. J. Immunol. (1997) [Pubmed]
  5. Decrease of glomerular disialogangliosides in puromycin nephrosis of the rat. Holthöfer, H., Reivinen, J., Solin, M.L., Haltia, A., Miettinen, A. Am. J. Pathol. (1996) [Pubmed]
  6. Heparan sulfate--rich anionic sites in the human glomerular basement membrane. Decreased concentration in congenital nephrotic syndrome. Vernier, R.L., Klein, D.J., Sisson, S.P., Mahan, J.D., Oegema, T.R., Brown, D.M. N. Engl. J. Med. (1983) [Pubmed]
  7. Chlorambucil for childhood nephrosis: a word of caution. Lewis, E.J. N. Engl. J. Med. (1980) [Pubmed]
  8. Targeted enzyme therapy of experimental glomerulonephritis in rats. White, R.B., Lowrie, L., Stork, J.E., Iskandar, S.S., Lamm, M.E., Emancipator, S.N. J. Clin. Invest. (1991) [Pubmed]
  9. Glomerular hypertrophy aggravates epithelial cell injury in nephrotic rats. Miller, P.L., Scholey, J.W., Rennke, H.G., Meyer, T.W. J. Clin. Invest. (1990) [Pubmed]
  10. Effect of aminonucleoside nephrosis on immune complex localization in autologous immune complex nephropathy in rats. Couser, W.G., Jermanovich, N.B., Belok, S., Stilmant, M.M., Hoyer, J.R. J. Clin. Invest. (1978) [Pubmed]
  11. Catabolism of very low density lipoproteins in experimental nephrosis. Garber, D.W., Gottlieb, B.A., Marsh, J.B., Sparks, C.E. J. Clin. Invest. (1984) [Pubmed]
  12. Dynamics of renal histamine in normal rat kidney and in nephrosis induced by aminonucleoside of puromycin. Abboud, H.E., Ou, S.L., Velosa, J.A., Shah, S.V., Dousa, T.P. J. Clin. Invest. (1982) [Pubmed]
  13. Localization of sialic acid in kidney glomeruli: regionalization in the podocyte plasma membrane and loss in experimental nephrosis. Charest, P.M., Roth, J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  14. Irreversible tubulointerstitial damage associated with chronic aminonucleoside nephrosis. Amelioration by angiotensin I converting enzyme inhibition. Diamond, J.R., Anderson, S. Am. J. Pathol. (1990) [Pubmed]
  15. Glomerular macrophages and the mesangial proliferative response in the experimental nephrotic syndrome. Diamond, J.R., Ding, G., Frye, J., Diamond, I.P. Am. J. Pathol. (1992) [Pubmed]
  16. Cloning and expression of the rat nephrin homolog. Ahola, H., Wang, S.X., Luimula, P., Solin, M.L., Holzman, L.B., Holthöfer, H. Am. J. Pathol. (1999) [Pubmed]
  17. Perinuclear distribution of plectin characterizes visceral epithelial cells of rat glomeruli. Yaoita, E., Wiche, G., Yamamoto, T., Kawasaki, K., Kihara, I. Am. J. Pathol. (1996) [Pubmed]
  18. Gene expression of hepatic cholesterol 7 alpha-hydroxylase in the course of puromycin-induced nephrosis. Liang, K.H., Oveisi, F., Vaziri, N.D. Kidney Int. (1996) [Pubmed]
  19. Possible mechanism of impaired calcium and vitamin D metabolism in nephrotic rats. Mizokuchi, M., Kubota, M., Tomino, Y., Koide, H. Kidney Int. (1992) [Pubmed]
  20. Modulation of basement membrane component gene expression in glomeruli of aminonucleoside nephrosis. Nakamura, T., Ebihara, I., Shirato, I., Tomino, Y., Koide, H. Lab. Invest. (1991) [Pubmed]
  21. Podocytic cytoskeletal disaggregation and basement-membrane detachment in puromycin aminonucleoside nephrosis. Whiteside, C.I., Cameron, R., Munk, S., Levy, J. Am. J. Pathol. (1993) [Pubmed]
  22. Production of an inhibitor of rat mesangial cell growth by the glomerulus and its alteration in puromycin nephrosis. Groggel, G.C., Hughes, M.L. J. Am. Soc. Nephrol. (1993) [Pubmed]
  23. Renal structural abnormalities following recovery from acute puromycin nephrosis. Rasch, R., Nyengaard, J.R., Marcussen, N., Meyer, T.W. Kidney Int. (2002) [Pubmed]
  24. L-arginine decreases the infiltration of the kidney by macrophages in obstructive nephropathy and puromycin-induced nephrosis. Reyes, A.A., Porras, B.H., Chasalow, F.I., Klahr, S. Kidney Int. (1994) [Pubmed]
  25. Effects of methylprednisolone on glomerular and medullary mRNA levels for extracellular matrices in puromycin aminonucleoside nephrosis. Nakamura, T., Ebihara, I., Fukui, M., Tomino, Y., Koide, H. Kidney Int. (1991) [Pubmed]
  26. Modulation of glomerular endothelin and endothelin receptor gene expression in aminonucleoside-induced nephrosis. Nakamura, T., Ebihara, I., Fukui, M., Osada, S., Tomino, Y., Masaki, T., Goto, K., Furuichi, Y., Koide, H. J. Am. Soc. Nephrol. (1995) [Pubmed]
  27. Downregulation of vascular endothelial growth factor and its receptors in the kidney in rats with puromycin aminonucleoside nephrosis. Fan, L., Wakayama, T., Yokoyama, S., Amano, O., Iseki, S. Nephron (2002) [Pubmed]
  28. Short-term effects of renal transplantation on plasma lipids and lipoprotein lipase in children with congenital nephrosis. Antikainen, M., Holmberg, C., Taskinen, M.R. Clin. Nephrol. (1994) [Pubmed]
  29. Attenuation of puromycin aminonucleoside-induced glomerular lesions in rats by CGS 26303, a dual neutral endopeptidase/endothelin-converting enzyme inhibitor. Feldman, D.L., Mogelesky, T.C., Chou, M., Jeng, A.Y. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  30. Changes in angiopoietin expression in glomeruli involved in glomerulosclerosis in rats with daunorubicin-induced nephrosis. Lu, Y.H., Deng, A.G., Li, N., Song, M.N., Yang, X., Liu, J.S. Acta Pharmacol. Sin. (2006) [Pubmed]
  31. Alpha-fetoprotein in antenatal diagnosis of congenital nephrosis. Kjessler, B., Johansson, S.G., Sherman, M., Gustavson, K.H., Hultquist, G. Lancet (1975) [Pubmed]
  32. Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling. Shibata, S., Nagase, M., Fujita, T. J. Am. Soc. Nephrol. (2006) [Pubmed]
  33. Effects of experimental nephrosis on basement-membrane components and enzymes of collagen biosynthesis in rat kidney. Jukkola, A., Risteli, J., Autio-Harmainen, H., Risteli, L. Biochem. J. (1985) [Pubmed]
  34. The role of circulating mevalonate in nephrotic hypercholesterolemia in the rat. Golper, T.A., Feingold, K.R., Fulford, M.H., Siperstein, M.D. J. Lipid Res. (1986) [Pubmed]
  35. Cathepsin B and L in nephron segments of rats with puromycin aminonucleoside nephrosis. Olbricht, C.J., Cannon, J.K., Tisher, C.C. Kidney Int. (1987) [Pubmed]
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