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Chemical Compound Review

Androsterine     3-hydroxy-10,13-dimethyl- 1,2,3,4,5,6,7,8,9...

Synonyms: AGN-PC-0054KF, NSC-93996, SureCN12968676, AC1Q6NOL, NSC93996, ...
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Disease relevance of EPIANDROSTERONE


Psychiatry related information on EPIANDROSTERONE

  • These findings indicate that 7beta-hydroxy epiandrosterone has powerful cytoprotective effects suggesting that (a) this neurosteroid may have therapeutic potential in various neurodegenerative conditions such as Alzheimer's disease, and (b) 7beta-hydroxy steroids may constitute a novel class of endogenous neuroprotective agents [6].

High impact information on EPIANDROSTERONE


Chemical compound and disease context of EPIANDROSTERONE


Biological context of EPIANDROSTERONE


Anatomical context of EPIANDROSTERONE

  • Using a specific anti-UGT2B17 antibody, the expression of this androsterone-conjugating UGT enzyme was found exclusively in basal cells of the epithelium [21].
  • The results of this study also provide evidence that differences in the content of 3 alpha-hydroxysteroid UDP-glucuronosyltransferase within hepatocytes account for genetically determined variations in the rates at which androsterone and certain other xenobiotics are glucuronidated in livers of Wistar rats [22].
  • Pulmonary arterial endothelial cells produced the same metabolites of [3H]androsterone (0.083 microM), with the exception of the polar compounds [5 alpha-androstane-3,17-dione (1.3 pmol mg-1 protein h-1), isoandrosterone (0.1 pmol mg-1 protein h-1), 5 alpha-DHT (0.2 pmol mg-1 protein h-1), and 3 alpha-diol (0.2 pmol mg-1 protein h-1)] [23].
  • Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid [6].
  • Foster-feeding experiments showed that breast milk did not alter the genetically determined expression of androsterone UDP-glucuronosyltransferase activity in Wistar rats [24].

Associations of EPIANDROSTERONE with other chemical compounds




Analytical, diagnostic and therapeutic context of EPIANDROSTERONE


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