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Chemical Compound Review:

AC1LCUWA 1-[(2R,3S,4R,5R)-3-fluoro-4- hydroxy-5...

Synonyms: 124I-FIAU, [124I]FIAU, 183293-72-3, UNII-726X882183, Fialuridine I-124

Hackman, T. et al., Koehne, G. et al., Tjuvajev, J.G. et al., Soghomonyan, S.A. et al., Jacobs, A. et al.

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Disease relevance of 2'-Fluoro-2'-deoxy-5'-[124I]iodo-1 -D-arabinofuranosyluracil

After adoptive transfer, HSV-TK+ T cells labeled in vitro or in vivo with [131I]FIAU or [124I]FIAU can be noninvasively tracked in SCID mice bearing human tumor xenografts by serial images obtained by scintigraphy or positron emission tomography (PET), respectively [1].

High impact information on 2'-Fluoro-2'-deoxy-5'-[124I]iodo-1 -D-arabinofuranosyluracil

We suggest that "clinically relevant" levels of HSV1-tk gene expression in transfected tissue can be imaged with [131I]FIAU and a gamma camera or SPECT, and that a significant improvement in imaging sensitivity and resolution is expected with [124I]FIAU and PET [2].
Quantitative kinetics of [124I]FIAU in cat and man [3].
Imaging with [124I]FIAU and PET could provide pre- and posttreatment assessments of CD/TK-based double prodrug activation in clinical gene therapy trials [4].
PET imaging of HSV1-TK subunit activity with [124I]FIAU was performed on these animals and demonstrated that different levels of CD/TK expression in subcutaneous W256CD/TK tumors can be imaged quantitatively [4].

Biological context of 2'-Fluoro-2'-deoxy-5'-[124I]iodo-1 -D-arabinofuranosyluracil

We assessed the efficacy of noninvasive imaging with [124I]FIAU (2'-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodo-uracil) and positron emission tomography (PET) for monitoring expression of the CD/TK fusion gene [4].

Analytical, diagnostic and therapeutic context of 2'-Fluoro-2'-deoxy-5'-[124I]iodo-1 -D-arabinofuranosyluracil

[124I]FIAU positron emission tomography (PET) and subsequent tissue radioactivity and bacterial concentration measurements were compared [5].

References

Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes. Koehne, G., Doubrovin, M., Doubrovina, E., Zanzonico, P., Gallardo, H.F., Ivanova, A., Balatoni, J., Teruya-Feldstein, J., Heller, G., May, C., Ponomarev, V., Ruan, S., Finn, R., Blasberg, R.G., Bornmann, W., Riviere, I., Sadelain, M., O'Reilly, R.J., Larson, S.M., Tjuvajev, J.G. Nat. Biotechnol. (2003) [Pubmed]
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Tjuvajev, J.G., Finn, R., Watanabe, K., Joshi, R., Oku, T., Kennedy, J., Beattie, B., Koutcher, J., Larson, S., Blasberg, R.G. Cancer Res. (1996) [Pubmed]
Quantitative kinetics of [124I]FIAU in cat and man. Jacobs, A., Bräunlich, I., Graf, R., Lercher, M., Sakaki, T., Voges, J., Hesselmann, V., Brandau, W., Wienhard, K., Heiss, W.D. J. Nucl. Med. (2001) [Pubmed]
Imaging expression of cytosine deaminase-herpes virus thymidine kinase fusion gene (CD/TK) expression with [124I]FIAU and PET. Hackman, T., Doubrovin, M., Balatoni, J., Beresten, T., Ponomarev, V., Beattie, B., Finn, R., Bornmann, W., Blasberg, R., Tjuvajev, J.G. Molecular imaging : official journal of the Society for Molecular Imaging. (2002) [Pubmed]
Positron emission tomography (PET) imaging of tumor-localized Salmonella expressing HSV1-TK. Soghomonyan, S.A., Doubrovin, M., Pike, J., Luo, X., Ittensohn, M., Runyan, J.D., Balatoni, J., Finn, R., Tjuvajev, J.G., Blasberg, R., Bermudes, D. Cancer Gene Ther. (2005) [Pubmed]

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