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Chemical Compound Review:

Dibestil [4-[(E)-4-(4- propanoyloxyphenyl)hex-3-en- 3...

Synonyms: Estilbin, Euvestin, Horfemine, Orestol, Oroestron, ...

Henderson, L. et al., Weijman, J. et al., Jacobi, J. et al., Migliore, L. et al., Lloyd, H.M. et al., et al.

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Disease relevance of Synestrol

Five-month-old male goats were treated with 25 mg diethylstilbestrol dipropionate (DES-DP) by a single intramuscular injection, causing characteristic histological alterations in the peripheral glandular epithelium of the prostate, resulting in squamous metaplasia [1].

High impact information on Synestrol

Five other pregnant females were injected with DESDP beginning on the 115th day of gestation and continuing until either the 140th day or term--a relatively short-term treatment [2].
Effects of diethylstilboestrol-dipropionate on SCEs, micronuclei, cytotoxicity, aneuploidy and cell proliferation in maternal and foetal mouse cells treated in vivo [3].
Application of the tetrazolium color reaction to the analysis of diethylstilbestrol dipropionate dosage forms was achieved without prior hydrolysis or extraction [4].
Haloperidol, bromocriptine and diethylstilboestrol dipropionate were given in various régimes to male rats to determine their effects on pituitary DNA synthesis, prolactin secretion and growth hormone secretion [5].
After the application of the FISH technique with a pancentromeric DNA sequence, DES, DESdp and GF showed a statistically significant increase in the percentage of positive signals compared with the control culture [6].

Biological context of Synestrol

Parturition was induced in ten buffaloes by combining treatments of dexamethasone and vetoestrol, so that they calved about one month before the expected term [7].

Anatomical context of Synestrol

The effect of diethylstilboestrol-dipropionate on the frequency of SCEs and micronuclei, cytotoxicity, aneuploidy and cell proliferation rates of foetal liver and maternal bone marrow cells following exposure of pregnant mice was measured [3].

Gene context of Synestrol

At intervals from 3 to 96 h after injection of 10 mg diethylstilboestrol dipropionate, serum and pituitary prolactin concentrations were measured by radioimmunoassay and pituitary DNA synthesis by incorporation of [3H]-thymidine in vitro [8].

Analytical, diagnostic and therapeutic context of Synestrol

In this experiment 20 one year old bulls received a single intramuscular injection of the anabolic preparation diethylstilbestrol dipropionate (DES-DP) (an oil preparation or an emulsion) [9].

References

Changing cytokeratin expression patterns in diethylstilbestrol dipropionate-induced metaplastic lesions of the goat prostate. Weijman, J., Ramaekers, F.C., Elsinghorst, T.A., van Wichen, P.J., Zwart, P. The Veterinary quarterly. (1992) [Pubmed]
The effects of diethylstilbestrol (DES) before birth on the development of masculine behavior in juvenile female rhesus monkeys. Goy, R.W., Deputte, B.L. Hormones and behavior. (1996) [Pubmed]
Effects of diethylstilboestrol-dipropionate on SCEs, micronuclei, cytotoxicity, aneuploidy and cell proliferation in maternal and foetal mouse cells treated in vivo. Henderson, L., Regan, T. Mutat. Res. (1985) [Pubmed]
Tetrazolium salts in pharmaceutical analysis II: direct assay of diethylstilbestrol and diethylstilbestrol dipropionate. Omar, N.M., El-Rabbat, N.A. Journal of pharmaceutical sciences. (1980) [Pubmed]
DNA synthesis and depletion of prolactin in the pituitary gland of the male rat. Lloyd, H.M., Jacobi, J.M., Meares, J.D. J. Endocrinol. (1978) [Pubmed]
Detection of the centromere in micronuclei by fluorescence in situ hybridization: its application to the human lymphocyte micronucleus assay after treatment with four suspected aneugens. Migliore, L., Cocchi, L., Scarpato, R. Mutagenesis (1996) [Pubmed]
Induction of parturition in water buffaloes (Bubalus bubalis ). Prakash, B.S., Madan, M.L. Theriogenology (1985) [Pubmed]
Onset of oestrogen-induced prolactin secretion and DNA synthesis by the rat pituitary gland. Jacobi, J., Lloyd, H.M., Meares, J.D. J. Endocrinol. (1977) [Pubmed]
Application of diethylstilbestrol dipropionate in bulls. I. Excretion of residues in urine and faeces and histological and immunohistochemical changes in the prostate. Jansen, E.H., Stephany, R.W., Vos, J.G., Ruitenberg, E.J., Benraad, T.J., de Boer, F., de Ruig, W.G., Weijman, J., Schmidt, N.A. The Veterinary quarterly. (1989) [Pubmed]

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