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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Parturition


Psychiatry related information on Parturition


High impact information on Parturition


Chemical compound and disease context of Parturition


Biological context of Parturition


Anatomical context of Parturition


Associations of Parturition with chemical compounds

  • Glucocorticoids accelerate fetal lung maturation in all mammals studied, and in some species, such as goat and sheep, concentrations of fetal cortisol increase sharply before term, bringing about a train of events leading to parturition [28].
  • Unlike progesterone antagonists, asoprisnil does not induce labor in relevant models of pregnancy and parturition [29].
  • Adequate response of plasma 1,25-dihydroxyvitamin D to parturition in paretic (milk fever) dairy cows [30].
  • However, mammary lobuloalveolar outgrowth during pregnancy was curtailed, and females failed to lactate after parturition because of a failure of terminal differentiation [31].
  • Changes in cells responsive to IL-7 were evident as early as 6.5 d of pregnancy and values were < 10% of normal at parturition [32].

Gene context of Parturition


Analytical, diagnostic and therapeutic context of Parturition


  1. Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3. Bond, C.T., Sprengel, R., Bissonnette, J.M., Kaufmann, W.A., Pribnow, D., Neelands, T., Storck, T., Baetscher, M., Jerecic, J., Maylie, J., Knaus, H.G., Seeburg, P.H., Adelman, J.P. Science (2000) [Pubmed]
  2. Lysyl oxidase is required for vascular and diaphragmatic development in mice. Hornstra, I.K., Birge, S., Starcher, B., Bailey, A.J., Mecham, R.P., Shapiro, S.D. J. Biol. Chem. (2003) [Pubmed]
  3. Normal levels of norepinephrine in short term hypothyroidism. Wahi, R.S., Chansouria, J.P., Udupa, K.N. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  4. Neutralization of relaxin within the brain affects the timing of birth in rats. Summerlee, A.J., Ramsey, D.G., Poterski, R.S. Endocrinology (1998) [Pubmed]
  5. The physiological release of specific individual neurophysins into the circulation of pigs. Dax, E.M., Cumming, I.A., Lawson, R.A., Johnston, C.I. Endocrinology (1977) [Pubmed]
  6. Prolactin stimulation of maternal behavior in female rats. Bridges, R.S., DiBiase, R., Loundes, D.D., Doherty, P.C. Science (1985) [Pubmed]
  7. A critical period in the onset of parturition in rats and uterine sensitivity to estradiol and progesterone. Marie, J., Legrand, C., Maltier, J.P., Scholler, R. Reproduction, nutrition, development. (1983) [Pubmed]
  8. The oxytocin receptor system: structure, function, and regulation. Gimpl, G., Fahrenholz, F. Physiol. Rev. (2001) [Pubmed]
  9. Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Wu, G., Markowitz, G.S., Li, L., D'Agati, V.D., Factor, S.M., Geng, L., Tibara, S., Tuchman, J., Cai, Y., Park, J.H., van Adelsberg, J., Hou, H., Kucherlapati, R., Edelmann, W., Somlo, S. Nat. Genet. (2000) [Pubmed]
  10. Local paracrine effects of estradiol are central to parturition in the rhesus monkey. Nathanielsz, P.W., Jenkins, S.L., Tame, J.D., Winter, J.A., Guller, S., Giussani, D.A. Nat. Med. (1998) [Pubmed]
  11. Role of cytosolic phospholipase A2 in allergic response and parturition. Uozumi, N., Kume, K., Nagase, T., Nakatani, N., Ishii, S., Tashiro, F., Komagata, Y., Maki, K., Ikuta, K., Ouchi, Y., Miyazaki, J., Shimizu, T. Nature (1997) [Pubmed]
  12. Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor. Karalis, K., Goodwin, G., Majzoub, J.A. Nat. Med. (1996) [Pubmed]
  13. The differential effects of thyroid and gonadal hormones on substance P content in the anterior pituitary of the prepubertal rat. Coslovsky, R., Braverman, L.E., Leeman, S.E., Aronin, N. Endocrinology (1985) [Pubmed]
  14. Relationships between prepartal dietary calcium and phosphorus, vitamin D metabolism, and parturient paresis in dairy cows. Kichura, T.S., Horst, R.L., Beitz, D.C., Littledike, E.T. J. Nutr. (1982) [Pubmed]
  15. Persistent c-fos induction by nicotine in developing rat brain regions: interaction with hypoxia. Trauth, J.A., Seidler, F.J., McCook, E.C., Slotkin, T.A. Pediatr. Res. (1999) [Pubmed]
  16. Effects of magnesium deficiency on parturition and uterine involution in the rat. Rayssiguier, Y., Badinand, F., Kopp, J. J. Nutr. (1979) [Pubmed]
  17. Use of EDTA to produce zinc deficiency in the pregnant rat. Apgar, J. J. Nutr. (1977) [Pubmed]
  18. Evidence for local stimulation of ACTH secretion by corticotropin-releasing factor in human placenta. Petraglia, F., Sawchenko, P.E., Rivier, J., Vale, W. Nature (1987) [Pubmed]
  19. Pregnancy maintenance and parturition: the role of prostaglandin in manipulating the immune and inflammatory response. Kelly, R.W. Endocr. Rev. (1994) [Pubmed]
  20. Estradiol and progesterone profiles indicate a lack of endocrine recognition of pregnancy in the opossum. Harder, J.D., Fleming, M.W. Science (1981) [Pubmed]
  21. Changes in bone density with lactation. Sowers, M., Corton, G., Shapiro, B., Jannausch, M.L., Crutchfield, M., Smith, M.L., Randolph, J.F., Hollis, B. JAMA (1993) [Pubmed]
  22. Serum relaxin in pregnancy. MacLennan, A.H., Nicolson, R., Green, R.C. Lancet (1986) [Pubmed]
  23. Structure of a genomic clone encoding biologically active human relaxin. Hudson, P., Haley, J., John, M., Cronk, M., Crawford, R., Haralambidis, J., Tregear, G., Shine, J., Niall, H. Nature (1983) [Pubmed]
  24. Developmental and functional biology of the primate fetal adrenal cortex. Mesiano, S., Jaffe, R.B. Endocr. Rev. (1997) [Pubmed]
  25. Stimulation of prostaglandin biosynthesis by urine of the human fetus may serve as a trigger for parturition. Strickland, D.M., Saeed, S.A., Casey, M.L., Mitchell, M.D. Science (1983) [Pubmed]
  26. Role of corticotropin-releasing hormone in onset of labour. Grammatopoulos, D.K., Hillhouse, E.W. Lancet (1999) [Pubmed]
  27. Structure, characterization, and expression of the rat oxytocin receptor gene. Rozen, F., Russo, C., Banville, D., Zingg, H.H. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  28. Direct evidence of sudden rise in fetal corticoids late in human gestation. Fencl, M.D., Stillman, R.J., Cohen, J., Tulchinsky, D. Nature (1980) [Pubmed]
  29. Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis. Chwalisz, K., Perez, M.C., Demanno, D., Winkel, C., Schubert, G., Elger, W. Endocr. Rev. (2005) [Pubmed]
  30. Adequate response of plasma 1,25-dihydroxyvitamin D to parturition in paretic (milk fever) dairy cows. Horst, R.L., Eisman, J.A., Jorgensen, N.A., DeLuca, H.F. Science (1977) [Pubmed]
  31. Stat5a is mandatory for adult mammary gland development and lactogenesis. Liu, X., Robinson, G.W., Wagner, K.U., Garrett, L., Wynshaw-Boris, A., Hennighausen, L. Genes Dev. (1997) [Pubmed]
  32. Suppression of B lymphopoiesis during normal pregnancy. Medina, K.L., Smithson, G., Kincade, P.W. J. Exp. Med. (1993) [Pubmed]
  33. Characterization and gestational regulation of corticotropin-releasing hormone messenger RNA in human placenta. Frim, D.M., Emanuel, R.L., Robinson, B.G., Smas, C.M., Adler, G.K., Majzoub, J.A. J. Clin. Invest. (1988) [Pubmed]
  34. Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition. Yu, Y., Cheng, Y., Fan, J., Chen, X.S., Klein-Szanto, A., Fitzgerald, G.A., Funk, C.D. J. Clin. Invest. (2005) [Pubmed]
  35. Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Takayanagi, Y., Yoshida, M., Bielsky, I.F., Ross, H.E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M.M., Young, L.J., Nishimori, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  36. Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Long, W., Wagner, K.U., Lloyd, K.C., Binart, N., Shillingford, J.M., Hennighausen, L., Jones, F.E. Development (2003) [Pubmed]
  37. Insulin-like growth factor II may play a local role in the regulation of ocular size. Cuthbertson, R.A., Beck, F., Senior, P.V., Haralambidis, J., Penschow, J.D., Coghlan, J.P. Development (1989) [Pubmed]
  38. Acetylcholinesterase in human amniotic fluid: An index of fetal neural development? Chubb, I.W., Pilowsky, P.M., Springell, H.J., Pollard, A.C. Lancet (1979) [Pubmed]
  39. Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse. Reese, J., Paria, B.C., Brown, N., Zhao, X., Morrow, J.D., Dey, S.K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  40. Differential GABAA receptor clustering determines GABA synapse plasticity in rat oxytocin neurons around parturition and the onset of lactation. Koksma, J.J., Fritschy, J.M., Mack, V., Van Kesteren, R.E., Brussaard, A.B. Mol. Cell. Neurosci. (2005) [Pubmed]
  41. Radioimmunoassay of relaxin throughout pregnancy and during parturition in the rat. Sherwood, O.D., Crnekovic, V.E., Gordon, W.L., Rutherford, J.E. Endocrinology (1980) [Pubmed]
  42. Divergent effects of antiprogesterone, RU 486, on progesterone, relaxin, and prolactin secretion in pregnant and hysterectomized pigs with aging corpora lutea. Li, Y.F., Huang, C.J., Klindt, J., Anderson, L.L. Endocrinology (1991) [Pubmed]
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