Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

PubChem13628 ethyl 2-aminobenzoate

Synonyms: SureCN34474, HSDB 404, NSC-4146, CCRIS 6238, AG-B-21321, ...

Tavoloni, N. et al., Compernolle, F. et al., Fevery, J. et al., De Schepper, J. et al., Saxerholt, H. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ETHYL ANTHRANILATE

Serum GOT, GPT, GGTP, 5' nucleotidase, total, direct, and conjugated (ethyl anthranilate-reactive) bilirubin, and bile salt concentrations were determined at entry into the study and at one week [1].
The bilirubin conjugate preparations were coupled with diazotized ethyl anthranilate and the formed ethyl anthranilate azopigments were quantified spectrophotometrically and separated by thin-layer chromatography (tlc) [2].
The activity of bilirubin-UDP-glucuronyl transferase (UDPGT) in rat liver microsomes was assayed in standardized incubation mixtures employing two different procedures to quantitate formation of conjugated bilirubin: solvent extraction and diazotization with sulfanilic acid, or selective coupling with diazotized ethyl anthranilate at pH 2 [3].
These assignments were verified, first by conversion of the structurally known 2-, 3- and 4-O-acyl glucuronide azopigments, unsubstituted at C-1, into ethyl anthranilate N-glucuronide reference compounds, and second, by mass spectrometry of trimethylsilyl ether methyl ester derivatives of unknown and reference compounds [4].

Analytical, diagnostic and therapeutic context of ETHYL ANTHRANILATE

Extracted pigment was submitted to thin-layer chromatography, and the separated bilirubins were either immediately eluted and determined spectrophotometrically or individually converted to ethyl anthranilate azo derivatives for thin-layer chromatographic analysis of each isolated pigment band [5].
Accurate and sensitive analysis of ethyl anthranilate azopigments from bile by reversed-phase high-performance liquid chromatography [6].
Thin-layer chromatographic separation of the azopigments of ethyl anthranilate revealed a good correlation between photometric scanning, radiochromatographic scanning and the radioactivity of the azopigments scraped off the thin-layer glass plates and counted in a liquid scintillation counter [7].
Bilirubin-IX beta isomer was detected in the bile of eel, Anguilla japonica, as evidenced by high-performance liquid chromatography (HPLC) analysis of free acid and its ethyl anthranilate diazo derivatives [8].

References

The effect of short-term total parenteral nutrition on hepatic function in the human neonate: a prospective randomized study demonstrating alteration of hepatic canalicular function. Black, D.D., Suttle, E.A., Whitington, P.F., Whitington, G.L., Korones, S.D. J. Pediatr. (1981) [Pubmed]
Methods for determination of conjugated bilirubin in rat faeces. Saxerholt, H., Midtvedt, T., Gustafsson, B.E. Scand. J. Clin. Lab. Invest. (1984) [Pubmed]
Comparison of different activators and diazotization procedures in the assay of bilirubin-UDP-glucuronyl transferase activity in rat liver. Tavoloni, N., Jones, M.J., Wittman, R., Kiang, C.L., Berk, P.D. Clin. Chim. Acta (1983) [Pubmed]
Rearranged glucuronic acid conjugates of bilirubin-IX alpha in post-obstructive bile. Structure elucidation of azopigments beta and gamma as ethyl anthranilate N-glycosides derived from 2-, 3- and 4-o-acyl glucuronides. Compernolle, F., Van Hees, G.P., Heirwegh, K.P. Biomed. Mass Spectrom. (1978) [Pubmed]
Analysis of bilirubins in biological fluids by extraction and thin-layer chromatography of the intact tetrapyrroles: application to bile of patients with Gilbert's syndrome, hemolysis, or cholelithiasis. Fevery, J., Blanckaert, N., Leroy, P., Michiels, R., Heirwegh, K.P. Hepatology (1983) [Pubmed]
Accurate and sensitive analysis of ethyl anthranilate azopigments from bile by reversed-phase high-performance liquid chromatography. Onishi, S., Itoh, S., Kawade, N., Isobe, K., Sugiyama, S. J. Chromatogr. (1980) [Pubmed]
Heterogeneity of bile pigments formed by the breakdown of haemoglobin in the isolated male-dog kidney. De Schepper, J., Van der Stock, J. Arch. Int. Physiol. Biochim. (1975) [Pubmed]
Occurrence of bilirubin-IX beta in the gallbladder bile of eel, Anguilla japonica. Sakai, T., Yamaguchi, T., Nakajima, H., Kono, N., Shimizu, C. Biochim. Biophys. Acta (1989) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share