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Chemical Compound Review

Trimsyl     trimethylsilicon

Synonyms: Trimethylsilyl, AR-1L7490, LS-194064, OR17012, AC1L3WF0, ...
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Disease relevance of trimethylsilicon


High impact information on trimethylsilicon

  • The structures of the products were confirmed by gas chromatography-mass spectrometry of the methyl ester trimethylsilyl ether derivatives as well as after characteristic epoxide ring opening catalytically with hydrogen leading to dihydroxy products [6].
  • The four stereoisomers of 2-hydroxy-3-methylvaleric acid have been synthesized and the mass spectra of their trimethylsilyl derivatives recorded [7].
  • Identification was by gas chromatography-mass spectrometry of the trimethylsilyl derivative and by analysis of the hydrolysis products [8].
  • The IL 2 was obtained free of contaminating proteins by a simple process consisting of an initial batch purification on trimethylsilyl-controlled pore glass followed by reversed phase high pressure liquid chromatography [9].
  • Following methylation of the carboxylic acid group and formation of trimethylsilyl ethers of the hydroxyl groups, the fragmentation pattern of the product was compatible with that of a monoglucuronide of 1,25-dihydroxyvitamin D3 [10].

Chemical compound and disease context of trimethylsilicon


Biological context of trimethylsilicon

  • Glycosylation of the trimethylsilyl derivative of 6-chloropyrazolo[3,4-d]pyrimidine-4-one unexpectedly gave the N2-glycosyl isomer 20 as the major product [12].
  • On the basis of this structural information, new catalysts were prepared in which the "bay region" tert-butyl groups were replaced by trimethylsilyl groups [13].
  • The target compounds 9-12 were obtained by an N1 regioselective intramolecular cyclization reaction of silylated 5-8 using trimethylsilyl trifluoromethanesulfonate (TMS triflate) as the catalyst [14].
  • We used high-resolution glass capillary columns to study the trimethylsilyl derivatives of some acidic metabolites found in pooled urine specimens form control and postpartum subjects [15].
  • Polyphosphoric acid trimethylsilyl ester promoted intramolecular acylation of an olefin by a carboxylic acid: convenient construction of C-18-functionalized delta14-hecogenin acetate [16].

Anatomical context of trimethylsilicon


Associations of trimethylsilicon with other chemical compounds


Gene context of trimethylsilicon


Analytical, diagnostic and therapeutic context of trimethylsilicon


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  13. Design and development of highly effective Lewis acid catalysts for enantioselective Diels-Alder reactions. Huang, Y., Iwama, T., Rawal, V.H. J. Am. Chem. Soc. (2002) [Pubmed]
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  16. Polyphosphoric acid trimethylsilyl ester promoted intramolecular acylation of an olefin by a carboxylic acid: convenient construction of C-18-functionalized delta14-hecogenin acetate. Li, W., Fuchs, P.L. Org. Lett. (2003) [Pubmed]
  17. Relationships among human amniotic fluid dipalmitoyl lecithin, postpartum respiratory compliance, and neonatal respiratory distress syndrome. Lohninger, A., Salzer, H., Simbruner, G., Husslein, P., Martin, G. Clin. Chem. (1983) [Pubmed]
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