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Gene Review

Ugt2b7  -  UDP glucuronosyltransferase 2 family,...

Rattus norvegicus

Synonyms: UDP-glucuronosyltransferase 2B7, UDPGT 2B7, UGT2B-RH4, Ugt2b8
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Disease relevance of LOC286989


High impact information on LOC286989

  • Indinavir was found to competitively inhibit UGT enzymatic activity (K(I) = 183 microM) while concomitantly inducing hepatic bilirubin UGT mRNA and protein expression [2].
  • The glucuronidation of testosterone, androsterone, and estrone was not catalyzed by this cloned UDP-glucuronosyltransferase [6].
  • The purified IgG was used for immunocytochemical localization of UDP-glucuronosyltransferase in rat liver, jejunum, kidney, and adrenal gland [7].
  • In addition, mRNA levels for ST2A2, a female-specific ST gene, were suppressed 50% in females and induced 120% over control in males. mRNA expression for all other forms of rat liver UGT and ST isozymes that were tested was not significantly affected by tamoxifen treatment [8].
  • Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts [9].

Chemical compound and disease context of LOC286989


Biological context of LOC286989


Anatomical context of LOC286989


Associations of LOC286989 with chemical compounds


Regulatory relationships of LOC286989


Other interactions of LOC286989


Analytical, diagnostic and therapeutic context of LOC286989


  1. Correction of the UDP-glucuronosyltransferase gene defect in the gunn rat model of crigler-najjar syndrome type I with a chimeric oligonucleotide. Kren, B.T., Parashar, B., Bandyopadhyay, P., Chowdhury, N.R., Chowdhury, J.R., Steer, C.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Mechanism of indinavir-induced hyperbilirubinemia. Zucker, S.D., Qin, X., Rouster, S.D., Yu, F., Green, R.M., Keshavan, P., Feinberg, J., Sherman, K.E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Persistently increased expression of a 3-methylcholanthrene-inducible phenol uridine diphosphate-glucuronosyltransferase in rat hepatocyte nodules and hepatocellular carcinomas. Bock, K.W., Münzel, P.A., Röhrdanz, E., Schrenk, D., Eriksson, L.C. Cancer Res. (1990) [Pubmed]
  4. Function and regulation of UDP-glucuronosyltransferase genes in health and liver disease: report of the Seventh International Workshop on Glucuronidation, September 1993, Pitlochry, Scotland. Burchell, B., Coughtrie, M.W., Jansen, P.L. Hepatology (1994) [Pubmed]
  5. Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats. Seppen, J., Bakker, C., de Jong, B., Kunne, C., van den Oever, K., Vandenberghe, K., de Waart, R., Twisk, J., Bosma, P. Mol. Ther. (2006) [Pubmed]
  6. Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells. Harding, D., Fournel-Gigleux, S., Jackson, M.R., Burchell, B. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  7. Distribution of UDPglucuronosyltransferase in rat tissue. Chowdhury, J.R., Novikoff, P.M., Chowdhury, N.R., Novikoff, A.B. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  8. Phase II enzyme expression in rat liver in response to the antiestrogen tamoxifen. Nuwaysir, E.F., Daggett, D.A., Jordan, V.C., Pitot, H.C. Cancer Res. (1996) [Pubmed]
  9. Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts. Vienneau, D.S., DeBoni, U., Wells, P.G. Cancer Res. (1995) [Pubmed]
  10. Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat). Iyanagi, T. J. Biol. Chem. (1991) [Pubmed]
  11. The effect of premature and delayed birth on the development of UDP-glucuronosyltransferase activities towards bilirubin, morphine and testosterone in the rat. Campbell, M.T., Wishart, G.J. Biochem. J. (1980) [Pubmed]
  12. The novel bilirubin/phenol UDP-glucuronosyltransferase UGT1 gene locus: implications for multiple nonhemolytic familial hyperbilirubinemia phenotypes. Owens, I.S., Ritter, J.K. Pharmacogenetics (1992) [Pubmed]
  13. Chronic physical activity: hepatic hypertrophy and increased total biotransformation enzyme activity. Yiamouyiannis, C.A., Sanders, R.A., Watkins, J.B., Martin, B.J. Biochem. Pharmacol. (1992) [Pubmed]
  14. A rapid in vitro method for the evaluation of potential antitumor drugs requiring metabolic activation by hepatic S9 enzymes. Lebsanft, J., McMahon, J.B., Steinmann, G.G., Shoemaker, R.H. Biochem. Pharmacol. (1989) [Pubmed]
  15. Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. Emi, Y., Ikushiro, S., Iyanagi, T. J. Biol. Chem. (1996) [Pubmed]
  16. Identification of a rat oltipraz-inducible UDP-glucuronosyltransferase (UGT1A7) with activity towards benzo(a)pyrene-7,8-dihydrodiol. Grove, A.D., Kessler, F.K., Metz, R.P., Ritter, J.K. J. Biol. Chem. (1997) [Pubmed]
  17. Molecular basis for the lack of bilirubin-specific and 3-methylcholanthrene-inducible UDP-glucuronosyltransferase activities in Gunn rats. The two isoforms are encoded by distinct mRNA species that share an identical single base deletion. Roy-Chowdhury, J., Huang, T.J., Kesari, K., Lederstein, M., Arias, I.M., Roy-Chowdhury, N. J. Biol. Chem. (1991) [Pubmed]
  18. The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation. Iyanagi, T., Watanabe, T., Uchiyama, Y. J. Biol. Chem. (1989) [Pubmed]
  19. Regulation of uridine diphosphate glucuronosyltransferase expression by phenolic antioxidants. Kashfi, K., Yang, E.K., Chowdhury, J.R., Chowdhury, N.R., Dannenberg, A.J. Cancer Res. (1994) [Pubmed]
  20. Rat liver UDP-glucuronosyltransferase. Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and beta-estradiol. Mackenzie, P.I. J. Biol. Chem. (1987) [Pubmed]
  21. Isolation and purification of rat liver morphine UDP-glucuronosyltransferase. Puig, J.F., Tephly, T.R. Mol. Pharmacol. (1986) [Pubmed]
  22. Evidence for an UDP-glucuronic acid/phenol glucuronide antiport in rat liver microsomal vesicles. Bánhegyi, G., Braun, L., Marcolongo, P., Csala, M., Fulceri, R., Mandl, J., Benedetti, A. Biochem. J. (1996) [Pubmed]
  23. Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase. Iyanagi, T., Haniu, M., Sogawa, K., Fujii-Kuriyama, Y., Watanabe, S., Shively, J.E., Anan, K.F. J. Biol. Chem. (1986) [Pubmed]
  24. Cloning and characterization of DNA complementary to rat liver UDP-glucuronosyltransferase mRNA. Mackenzie, P.I., Gonzalez, F.J., Owens, I.S. J. Biol. Chem. (1984) [Pubmed]
  25. Photolysis products of 2,4,5,2',4',5'-hexabromobiphenyl: hepatic microsomal enzyme induction and toxicity in Sprague-Dawley rats. Millis, C.D., Mills, R., Sleight, S.D., Aust, S.D. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1985) [Pubmed]
  26. Rat liver UDP-glucuronosyltransferase. cDNA sequence and expression of a form glucuronidating 3-hydroxyandrogens. Mackenzie, P.I. J. Biol. Chem. (1986) [Pubmed]
  27. Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter. Mackenzie, P.I., Rodbourn, L. J. Biol. Chem. (1990) [Pubmed]
  28. Purification and properties of a rat liver phenobarbital-inducible 4-hydroxybiphenyl UDP-glucuronosyltransferase. Styczynski, P., Green, M., Puig, J., Coffman, B., Tephly, T. Mol. Pharmacol. (1991) [Pubmed]
  29. Histone 2A stimulates glucose-6-phosphatase activity by permeabilization of liver microsomes. Benedetti, A., Fulceri, R., Allan, B.B., Houston, P., Sukhodub, A.L., Marcolongo, P., Ethell, B., Burchell, B., Burchell, A. Biochem. J. (2002) [Pubmed]
  30. Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study. McKim, J.M., Wilga, P.C., Kolesar, G.B., Choudhuri, S., Madan, A., Dochterman, L.W., Breen, J.G., Parkinson, A., Mast, R.W., Meeks, R.G. Toxicol. Sci. (1998) [Pubmed]
  31. Expression of specific UDP-glucuronosyltransferase isoforms in carcinogen-induced preneoplastic rat liver nodules. Chowdhury, N.R., Saber, M.A., Lahiri, P., Mackenzie, P.I., Novikoff, P.M., Becker, F.F., Chowdhury, J.R. Hepatology (1991) [Pubmed]
  32. A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids. Pritchard, M., Fournel-Gigleux, S., Siest, G., Mackenzie, P., Magdalou, J. Mol. Pharmacol. (1994) [Pubmed]
  33. Induction of UDP-glucuronosyltransferase activity in the Reuber H-4-II-E hepatoma cell culture. Malik, N., Koteen, G.M., Owens, I.S. Mol. Pharmacol. (1979) [Pubmed]
  34. Identification of glutathione conjugates of the dimethyl ester of bilirubin in the bile of Gunn rats. Odell, G.B., Mogilevsky, W.S., Smith, P.B., Fenselau, C. Mol. Pharmacol. (1991) [Pubmed]
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