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Chemical Compound Review:

Mesidine 2,4,6-trimethylaniline

Synonyms: Mesidin, Mesitylamine, SureCN139002, CCRIS 2871, AG-H-55008, ...

Przybojewska, B., Przybojewska, B., Kovi, J. et al., Roe, J.A. et al., Weisburger, E.K. et al.

Przybojewska,

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Disease relevance of Mesidine monohydrochloride

The chromosomal constitution of a mammosomatotrophic and an inactive transplantable pituitary tumor induced in rats by 2,4,6-trimethylaniline was studied by the Giemsa-banding techniques [1].
2,4,6-Trimethylaniline led to cirrhosis of the liver in rats only [2].
In conclusion, taking into account the results mentioned above and the results obtained by other researchers who reported mutagenic activity of 2,4-dimethylaniline and 2,4,6-trimethylaniline in Salmonella typhimurium assay and in a DNA repair test using Chinese hamster hepatocytes, it can be stated that both aromatic amines are genotoxic [3].

High impact information on Mesidine monohydrochloride

The reaction of CCP compound ES with mesidine is biphasic, while similar reactions using compound II give monophasic kinetics [4].
The effect of 2,4-dimethylaniline and 2,4,6-trimethylaniline was studied after single intraperitoneal injections at doses equal to 100, 200 mg/kg and 150, 300 mg/kg body wt., respectively [5].
The alkaline single cell gel electrophoresis (SCGE) or 'comet' assay under alkaline conditions was used to measure DNA damage in the liver cells of B6C3F1 male mice exposed to 2,4-dimethylaniline and 2,4,6-trimethylaniline [5].
It was found that 2, 4-dimethylaniline and 2,4,6-trimethylaniline were able to damage DNA in the liver cells of the mice [3].

Biological context of Mesidine monohydrochloride

Chromosome banding patterns of two transplantable pituitary tumors induced in rats by 2,4,6-trimethylaniline [1].

References

Chromosome banding patterns of two transplantable pituitary tumors induced in rats by 2,4,6-trimethylaniline. Kovi, J., Morris, H.P., Kovi, E. J. Natl. Cancer Inst. (1977) [Pubmed]
Testing of twenty-one environmental aromatic amines or derivatives for long-term toxicity or carcinogenicity. Weisburger, E.K., Russfield, A.B., Homburger, F., Weisburger, J.H., Boger, E., Van Dongen, C.G., Chu, K.C. Journal of environmental pathology and toxicology. (1978) [Pubmed]
Assessment of aniline derivatives-induced DNA damage in the liver cells of B6C3F1 mice using the alkaline single cell gel electrophoresis ("comet") assay. Przybojewska, B. Teratog., Carcinog. Mutagen. (1999) [Pubmed]
Enhanced oxidation of aniline derivatives by two mutants of cytochrome c peroxidase at tryptophan 51. Roe, J.A., Goodin, D.B. J. Biol. Chem. (1993) [Pubmed]
Assessment of aniline derivatives-induced DNA damage in the liver cells of B6C3F1 mice using the alkaline single cell gel electrophoresis ('comet') assay. Przybojewska, B. Cancer Lett. (1999) [Pubmed]

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