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Chemical Compound Review:

PubChem12494 2-phenoxyethanamide

Synonyms: AGN-PC-0D6CDT, SureCN138162, NSC-1865, ACMC-20ajx9, CCG-45564, ...

Savontaus, E. et al., Waghe, M. et al., Kerr, D.E. et al.

Waghe, Westwood, Nunn, Kalinowski, Aldridge,

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Disease relevance of NSC1865

Pretreatment with the mAb-PVA conjugates did not enhance the toxicity of MelPO in either cell line, because PVA hydrolyzes the phenoxyacetamide bond of MelPO too slowly to generate a toxic level of melphalan [1].

High impact information on NSC1865

Chronic treatment of obese fa/fa Zucker rats with celiprolol (50 mg/kg/day orally for 20 days) increased GDP binding to brown fat mitochondria by 1.5-fold, whereas beta(3)-adrenoceptor agonist ZD7114 ((S)-4-[2-[(2-hydroxy-3-phenoxypropyl)amino]ethoxy]-N-(2-methoxyet hyl )phenoxyacetamide, 3 mg/kg/day) increased the binding by 3.3-fold [2].
ZD7114, [(S)-4-[2-(2-hydroxy-3 phenoxypropylamine)ethoxy]-N-(2-methoxyethyl) phenoxyacetamide], and ZD2079, [(R)-N-(2-[4- (carboxymethyl)phenoxy]ethyl)-N-(beta-hydroxyphenethyl)ammonium chloride], are beta 3-adrenoceptor stimulants with selectivity for brown adipose tissue [3].

References

Antibody-penicillin-V-amidase conjugates kill antigen-positive tumor cells when combined with doxorubicin phenoxyacetamide. Kerr, D.E., Senter, P.D., Burnett, W.V., Hirschberg, D.L., Hellström, I., Hellström, K.E. Cancer Immunol. Immunother. (1990) [Pubmed]
Effects of chronic celiprolol treatment on brown fat, feeding, and drinking in fa/fa Zucker rats. Savontaus, E., Rouru, J., Malminiemi, K., Luukkaa, V., Pesonen, U., Koulu, M., Huupponen, R. Pharmacol. Biochem. Behav. (2000) [Pubmed]
Urinary tract toxicity in rats following administration of beta 3-adrenoceptor agonists. Waghe, M., Westwood, R., Nunn, G., Kalinowski, A., Aldridge, A. Toxicologic pathology. (1999) [Pubmed]

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