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MeSH Review

Rats, Zucker

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Disease relevance of Rats, Zucker


Psychiatry related information on Rats, Zucker


High impact information on Rats, Zucker

  • Here we show that leptin hyperpolarizes glucose-receptive hypothalamic neurons of lean Sprague-Dawley and Zucker rats, but is ineffective on neurons of obese Zucker (fa/fa) rats [11].
  • To our knowledge, these data provided the first direct measurements of insulin signaling in the vascular tissues, and documented a selective resistance to PI 3-kinase (but not to MAP kinase pathway) in the vascular tissues of obese Zucker rats [12].
  • Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats [13].
  • To study the regulation of apoA-IV gene expression by genetic and nutritional factors, we determined the effect of a fish oil-rich and a sucrose-rich diet on apoA-IV gene transcription and nuclear and total cellular apoA-IV mRNA abundance in livers of genetically obese, hyperlipoproteinemic (fa/fa) Zucker rats and their lean (Fa/-) littermates [14].
  • Leptin failed to affect food intake or body temperature in obese (fa/fa) Zucker rats, which posses a defective leptin receptor [15].

Chemical compound and disease context of Rats, Zucker

  • Results suggest that pyruvate consumption reduced the weight gain and food-conversion efficiency of obese Zucker rats, in part by increasing resting metabolic rate and fatty acid oxidation [16].
  • After 0.4% DHEA was administered for 10 days to female obese Zucker rats aged 16 weeks, body weight and plasma insulin decreased and glucose disposal rate (GDR), which was normally reduced in obese rats, rose significantly compared with age- and sex-matched control obese rats [17].
  • We suggest that defective regulation of PVN NE reflects and contributes to the development and/or maintenance of obesity in Zucker rats via central hypoactivity of the sympathetic system [18].
  • To assess GLUT4 and GLUT1 expression in genetic obesity, similar studies were carried out in 5- and 20-week-old lean and obese Zucker rats as well as in 20-week-old obese Zucker rats 36 h after streptozotocin injection to lower insulin levels [19].
  • To assess the role of insulin in developing obesity, diazoxide (DZ), an inhibitor of glucose-stimulated insulin secretion, was administered for 8 weeks to 7-week-old female Zucker rats in two concentrations, 50 mg/ (LD-DZ), and 100 mg/ (HD-DZ) [20].

Biological context of Rats, Zucker


Anatomical context of Rats, Zucker


Associations of Rats, Zucker with chemical compounds


Gene context of Rats, Zucker


Analytical, diagnostic and therapeutic context of Rats, Zucker


  1. Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. Wu, B.J., Kathir, K., Witting, P.K., Beck, K., Choy, K., Li, C., Croft, K.D., Mori, T.A., Tanous, D., Adams, M.R., Lau, A.K., Stocker, R. J. Exp. Med. (2006) [Pubmed]
  2. Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine withdrawal. Heinrichs, S.C., Lapsansky, J., Behan, D.P., Chan, R.K., Sawchenko, P.E., Lorang, M., Ling, N., Vale, W.W., De Souza, E.B. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Unger, R.H. Diabetes (1995) [Pubmed]
  4. Gastric inhibitory polypeptide (GIP) and insulin release in the obese Zucker rat. Chan, C.B., Pederson, R.A., Buchan, A.M., Tubesing, K.B., Brown, J.C. Diabetes (1984) [Pubmed]
  5. Bile secretory function in the obese Zucker rat: evidence of cholestasis and altered canalicular transport function. Pizarro, M., Balasubramaniyan, N., Solís, N., Solar, A., Duarte, I., Miquel, J.F., Suchy, F.J., Trauner, M., Accatino, L., Ananthanarayanan, M., Arrese, M. Gut (2004) [Pubmed]
  6. Feeding pattern in obese Zucker rats after dopaminergic and serotonergic LHA grafts. Meguid, M.M., Fetissov, S.O., Miyata, G., Torelli, G.F. Neuroreport (1999) [Pubmed]
  7. Effect of food deprivation on regional brain glucose utilization in lean and fatty Zucker rats. Tsujii, S., Nakai, Y., Takahashi, H., Usui, T., Koh, T., Yonekura, Y., Konishi, J., Imura, H. Brain Res. (1988) [Pubmed]
  8. The effect of dehydroepiandrosterone on Zucker rats selected for fat food preference. Pham, J., Porter, J., Svec, D., Eiswirth, C., Svec, F. Physiol. Behav. (2000) [Pubmed]
  9. Resistance of the obese Zucker rat to insulin-induced feeding and to satiety induced by coinfusion of insulin and glucose. Orosco, M., Rouch, C., Nicolaidis, S. Appetite. (1994) [Pubmed]
  10. Role of pylorus in mediating cholecystokinin-stimulated satiety in the Zucker rat. Berk, T., Crochelt, R.F., Peikin, S.R. Dig. Dis. Sci. (1986) [Pubmed]
  11. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Spanswick, D., Smith, M.A., Groppi, V.E., Logan, S.D., Ashford, M.L. Nature (1997) [Pubmed]
  12. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. Jiang, Z.Y., Lin, Y.W., Clemont, A., Feener, E.P., Hein, K.D., Igarashi, M., Yamauchi, T., White, M.F., King, G.L. J. Clin. Invest. (1999) [Pubmed]
  13. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. Okuno, A., Tamemoto, H., Tobe, K., Ueki, K., Mori, Y., Iwamoto, K., Umesono, K., Akanuma, Y., Fujiwara, T., Horikoshi, H., Yazaki, Y., Kadowaki, T. J. Clin. Invest. (1998) [Pubmed]
  14. Altered regulation of apolipoprotein A-IV gene expression in the liver of the genetically obese Zucker rat. Strobl, W., Knerer, B., Gratzl, R., Arbeiter, K., Lin-Lee, Y.C., Patsch, W. J. Clin. Invest. (1993) [Pubmed]
  15. Leptin actions on food intake and body temperature are mediated by IL-1. Luheshi, G.N., Gardner, J.D., Rushforth, D.A., Loudon, A.S., Rothwell, N.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  16. Effects of pyruvate and dihydroxyacetone consumption on the growth and metabolic state of obese Zucker rats. Cortez, M.Y., Torgan, C.E., Brozinick, J.T., Miller, R.H., Ivy, J.L. Am. J. Clin. Nutr. (1991) [Pubmed]
  17. Dehydroepiandrosterone decreases serum tumor necrosis factor-alpha and restores insulin sensitivity: independent effect from secondary weight reduction in genetically obese Zucker fatty rats. Kimura, M., Tanaka, S., Yamada, Y., Kiuchi, Y., Yamakawa, T., Sekihara, H. Endocrinology (1998) [Pubmed]
  18. Decreased central and peripheral catecholaminergic activation in obese Zucker rats. Pacak, K., McCarty, R., Palkovits, M., Cizza, G., Kopin, I.J., Goldstein, D.S., Chrousos, G.P. Endocrinology (1995) [Pubmed]
  19. Suppression of GLUT4 expression in skeletal muscle of rats that are obese from high fat feeding but not from high carbohydrate feeding or genetic obesity. Kahn, B.B., Pedersen, O. Endocrinology (1993) [Pubmed]
  20. Modification of insulin resistance by diazoxide in obese Zucker rats. Alemzadeh, R., Slonim, A.E., Zdanowicz, M.M., Maturo, J. Endocrinology (1993) [Pubmed]
  21. Tissue-specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats. Crist, G.H., Xu, B., Lanoue, K.F., Lang, C.H. FASEB J. (1998) [Pubmed]
  22. Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats. Kim, Y.B., Peroni, O.D., Franke, T.F., Kahn, B.B. Diabetes (2000) [Pubmed]
  23. Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding. Harrold, J.A., Widdowson, P.S., Williams, G. Diabetes (1999) [Pubmed]
  24. Characterization of bone structure in leptin receptor-deficient Zucker (fa/fa) rats. Tamasi, J.A., Arey, B.J., Bertolini, D.R., Feyen, J.H. J. Bone Miner. Res. (2003) [Pubmed]
  25. AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats. Ljung, B., Bamberg, K., Dahllöf, B., Kjellstedt, A., Oakes, N.D., Ostling, J., Svensson, L., Camejo, G. J. Lipid Res. (2002) [Pubmed]
  26. Differentiation-dependent expression of CA V and the role of carbonic anhydrase isozymes in pyruvate carboxylation in adipocytes. Hazen, S.A., Waheed, A., Sly, W.S., LaNoue, K.F., Lynch, C.J. FASEB J. (1996) [Pubmed]
  27. Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. Bergeron, R., Previs, S.F., Cline, G.W., Perret, P., Russell, R.R., Young, L.H., Shulman, G.I. Diabetes (2001) [Pubmed]
  28. Studies on the regulation of insulin binding by liver plasma membranes from Zucker fatty rats. Clark, J.B., Keen, S., Clark, C.M. Diabetes (1982) [Pubmed]
  29. Insulin and glucagon release from cultured neonatal pancreatic islets of lean and preobese Zucker rats. Hayek, A. Diabetes (1982) [Pubmed]
  30. Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats. Standridge, M., Alemzadeh, R., Zemel, M., Koontz, J., Moustaid-Moussa, N. FASEB J. (2000) [Pubmed]
  31. Oxidative stress in fatty livers of obese Zucker rats: rapid amelioration and improved tolerance to warm ischemia with tocopherol. Soltys, K., Dikdan, G., Koneru, B. Hepatology (2001) [Pubmed]
  32. Peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats. Buckingham, R.E., Al-Barazanji, K.A., Toseland, C.D., Slaughter, M., Connor, S.C., West, A., Bond, B., Turner, N.C., Clapham, J.C. Diabetes (1998) [Pubmed]
  33. Contributions of fatty acid and sterol synthesis to triglyceride and cholesterol secretion by the perfused rat liver in genetic hyperlipemia and obesity. Azain, M.J., Fukuda, N., Chao, F.F., Yamamoto, M., Ontko, J.A. J. Biol. Chem. (1985) [Pubmed]
  34. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Lynn, F.C., Pamir, N., Ng, E.H., McIntosh, C.H., Kieffer, T.J., Pederson, R.A. Diabetes (2001) [Pubmed]
  35. Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. Dalen, K.T., Schoonjans, K., Ulven, S.M., Weedon-Fekjaer, M.S., Bentzen, T.G., Koutnikova, H., Auwerx, J., Nebb, H.I. Diabetes (2004) [Pubmed]
  36. Apolipoprotein AV does not contribute to hypertriglyceridaemia or triglyceride lowering by dietary fish oil and rosiglitazone in obese Zucker rats. Dorfmeister, B., Brandlhofer, S., Schaap, F.G., Hermann, M., Fürnsinn, C., Hagerty, B.P., Stangl, H., Patsch, W., Strobl, W. Diabetologia (2006) [Pubmed]
  37. Differential regulation of glomerular gelatinase B (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in obese Zucker rats. Schaefer, L., Han, X., August, C., Matzkies, F., Lorenz, T., Schaefer, R.M. Diabetologia (1997) [Pubmed]
  38. Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway. Selzner, M., Clavien, P.A. Hepatology (2000) [Pubmed]
  39. Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. Pederson, R.A., White, H.A., Schlenzig, D., Pauly, R.P., McIntosh, C.H., Demuth, H.U. Diabetes (1998) [Pubmed]
  40. Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats. Possible relationship to obesity and neuroendocrine disturbances. McKibbin, P.E., Cotton, S.J., McMillan, S., Holloway, B., Mayers, R., McCarthy, H.D., Williams, G. Diabetes (1991) [Pubmed]
  41. Intraglomerular fibronectin accumulation and degradation in obese Zucker rats. Paczek, L., Teschner, M., Schaefer, R.M., Heidland, A. Diabetologia (1991) [Pubmed]
  42. Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats. Balkan, B., Kwasnik, L., Miserendino, R., Holst, J.J., Li, X. Diabetologia (1999) [Pubmed]
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