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Chemical Compound Review

celiprolol     3-[3-ethanoyl-4-[2-hydroxy-3- (tert...

Synonyms: Celectol, Celiprololum, CHEMBL27810, SureCN49415, AGN-PC-008H1D, ...
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Disease relevance of Selectol


Psychiatry related information on Selectol


High impact information on Selectol


Chemical compound and disease context of Selectol


Biological context of Selectol

  • Celiprolol is a 'third generation' beta-blocking agent which is claimed to avoid problems associated with simpler beta-blockers, such as vasoconstriction, bronchoconstriction and myocardial depression [3].
  • Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol [10].
  • Celiprolol increased cardiac and stroke volume indices and the EF; the PAOP was reduced without change in other measured variables [15].
  • The metabolic effects of celiprolol, a new beta-adrenoceptor blocking agent with intrinsic sympathomimetic activity and alpha 2-blocking properties, were evaluated in a series of patients with hypertension, both with and without hyperlipidemia [16].
  • Some studies suggest that celiprolol, because of vasodilation, may be less likely to reduce blood flow to the peripheries than other beta-adrenoceptor blocking drugs and hence cause fewer peripheral vascular side effects [4].

Anatomical context of Selectol


Associations of Selectol with other chemical compounds


Gene context of Selectol


Analytical, diagnostic and therapeutic context of Selectol


  1. Effect of beta-adrenergic blockade on exercise performance in patients with chronic atrial fibrillation. Atwood, J.E., Sullivan, M., Forbes, S., Myers, J., Pewen, W., Olson, H.G., Froelicher, V.F. J. Am. Coll. Cardiol. (1987) [Pubmed]
  2. Effects of celiprolol on cardiovascular reactivity to laboratory stressors in patients with hypertension. Cardillo, C., Degen, C., De Felice, F., Folli, G. Clin. Pharmacol. Ther. (1992) [Pubmed]
  3. Acute haemodynamic profile of celiprolol in patients with coronary heart disease and hypertension: a double-blind comparison with metoprolol. Heublein, B., Modersohn, D., Franz, N., Panzner, B. Eur. Heart J. (1991) [Pubmed]
  4. Celiprolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties and its therapeutic use in hypertension and angina pectoris. Riddell, J.G., Shanks, R.G., Brogden, R.N. Drugs (1987) [Pubmed]
  5. Effect of celiprolol treatment in hypertensive patients with sleep apnea. Planès, C., Foucher, A., Leroy, M., Dartois, N., Juste, K., Baillart, O., Raffestin, B. Sleep. (1999) [Pubmed]
  6. Effects of selected beta-adrenergic blocking agents on sleep stages in spontaneously hypertensive rats. Ongini, E., Milani, S., Marzanatti, M., Trampus, M., Monopoli, A. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  7. Quality of life before and during antihypertensive treatment: a comparative study of celiprolol and atenolol. Cleophas, T.J., van der Mey, N., van der Meulen, J., Niemeyer, M.G. International journal of clinical pharmacology and therapeutics. (1996) [Pubmed]
  8. Celiprolol, a beta-adrenoceptor antagonist with vasodilator effect, improves hemodynamic response to catecholamine, spontaneous locomotor activity, and survival in cardiomyopathic hamsters with advanced heart failure. Nakamura, Y., Ryoke, T., Tanaka, N., Ohkusa, T., Matsuzaki, M. J. Cardiovasc. Pharmacol. (1998) [Pubmed]
  9. Influence of chronic exposure to high concentrations of D-glucose and long-term beta-blocker treatment on intracellular calcium concentrations of porcine aortic endothelial cells. Salameh, A., Dhein, S. Diabetes (1998) [Pubmed]
  10. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Lilja, J.J., Juntti-Patinen, L., Neuvonen, P.J. Clin. Pharmacol. Ther. (2004) [Pubmed]
  11. Celiprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in cardiovascular disease. Milne, R.J., Buckley, M.M. Drugs (1991) [Pubmed]
  12. Comparison of celiprolol and propranolol in stable angina pectoris. Celiprolol International Angina Study Group. Frishman, W.H., Heiman, M., Soberman, J., Greenberg, S., Eff, J. Am. J. Cardiol. (1991) [Pubmed]
  13. Distinct pathways for beta-adrenoceptor-induced up-regulation of muscarinic acetylcholine receptors and inhibitory G-protein alpha-subunits in chicken cardiomyocytes. Reithmann, C., Panzner, B., Werdan, K. Naunyn Schmiedebergs Arch. Pharmacol. (1992) [Pubmed]
  14. Effects of celiprolol on plasma renin, aldosterone, norepinephrine and epinephrine in primary hypertension. Kimura, S., DeQuattro, V., Hernandez, P.H., Lee, D.D. Am. J. Cardiol. (1988) [Pubmed]
  15. Comparative effects of metoprolol and celiprolol on cardiac hemodynamics and left ventricular volume at rest and during exercise-induced angina. Silke, B., Verma, S.P., Frais, M.A., Reynolds, G., Taylor, S.H. Clin. Pharmacol. Ther. (1986) [Pubmed]
  16. Lipid effects of celiprolol, a new cardioselective beta-blocker, versus propranolol. Sirtori, C.R., Johnson, B., Vaccarino, V., Montanari, G., Cremoncini, M., Gianfranceschi, G., Sirtori, M., Dujovne, C.A. Clin. Pharmacol. Ther. (1989) [Pubmed]
  17. Cardiovascular mass and ventricular function after celiprolol in Wistar-Kyoto and spontaneously hypertensive rats. Horinaka, S., Frohlich, E.D. Cardiovasc. Res. (1992) [Pubmed]
  18. Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein. Karlsson, J., Kuo, S.M., Ziemniak, J., Artursson, P. Br. J. Pharmacol. (1993) [Pubmed]
  19. Release of endothelial nitric oxide in coronary arteries by celiprolol, a beta(1)-adrenoceptor antagonist: possible clinical relevance. Noda, K., Oka, M., Ma, F.H., Kitazawa, S., Ukai, Y., Toda, N. Eur. J. Pharmacol. (2001) [Pubmed]
  20. The central and peripheral hemodynamics of celiprolol. Mancia, G. Am. Heart J. (1988) [Pubmed]
  21. Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol. Lilja, J.J., Backman, J.T., Laitila, J., Luurila, H., Neuvonen, P.J. Clin. Pharmacol. Ther. (2003) [Pubmed]
  22. Haemodynamic effects of new beta-blockers with vasodilatory properties in essential hypertension. Tsukiyama, H., Otsuka, K., Horii, M. Drugs (1988) [Pubmed]
  23. Pharmacological actions of the selective and non-selective beta-adrenoceptor antagonists celiprolol, bisoprolol and propranolol on human bronchi. Hauck, R.W., Schulz, C., Emslander, H.P., Böhm, M. Br. J. Pharmacol. (1994) [Pubmed]
  24. CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell lines suitable for drug transport studies. Engman, H.A., Lennernäs, H., Taipalensuu, J., Otter, C., Leidvik, B., Artursson, P. Journal of pharmaceutical sciences. (2001) [Pubmed]
  25. Celiprolol inhibits mitogen-activated protein kinase and endothelin-1 and transforming growth factor-beta(1) gene in rats. Tsubokou, Y., Kobayashi, N., Mita, S., Yoshida, K., Matsuoka, H. Eur. J. Pharmacol. (2002) [Pubmed]
  26. Comparison of the effect of celiprolol and nifedipine on blood pressure and plasma lipids. van Hoof, R., Desager, J.P., Harvengt, C., Fagard, R., Lijnen, P., Peerenboom, P., Staessen, J., Thijs, L., Van Mieghem, W., Amery, A. J. Cardiovasc. Pharmacol. (1992) [Pubmed]
  27. Celiprolol stimulates endothelial nitric oxide synthase expression and improves myocardial remodeling in deoxycorticosterone acetate-salt hypertensive rats. Kobayashi, N., Mori, Y., Nakano, S., Tsubokou, Y., Shirataki, H., Matsuoka, H. J. Hypertens. (2001) [Pubmed]
  28. Experimental design for enantioselective separation of celiprolol by capillary electrophoresis using sulfated beta-cyclodextrin. Daali, Y., Cherkaoui, S., Christen, P., Veuthey, J.L. Electrophoresis (1999) [Pubmed]
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