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Gene Review

Adrb3  -  adrenoceptor beta 3

Rattus norvegicus

Synonyms: Adrb3r, Beta-3 adrenergic receptor, Beta-3 adrenoceptor, Beta-3 adrenoreceptor
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Disease relevance of Adrb3


High impact information on Adrb3


Chemical compound and disease context of Adrb3


Biological context of Adrb3


Anatomical context of Adrb3


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Regulatory relationships of Adrb3


Other interactions of Adrb3


Analytical, diagnostic and therapeutic context of Adrb3


  1. CL-316,243, a beta3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese rats. de Souza, C.J., Hirshman, M.F., Horton, E.S. Diabetes (1997) [Pubmed]
  2. Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence. Tanaka, N., Tamai, T., Mukaiyama, H., Hirabayashi, A., Muranaka, H., Ishikawa, T., Kobayashi, J., Akahane, S., Akahane, M. J. Med. Chem. (2003) [Pubmed]
  3. Efficacy of the beta3-adrenergic receptor agonist CL-316243 on experimental bladder hyperreflexia and detrusor instability in the rat. Woods, M., Carson, N., Norton, N.W., Sheldon, J.H., Argentieri, T.M. J. Urol. (2001) [Pubmed]
  4. Further evidence for differences between cardiac atypical beta-adrenoceptors and brown adipose tissue beta3-adrenoceptors in the pithed rat. Malinowska, B., Schlicker, E. Br. J. Pharmacol. (1997) [Pubmed]
  5. Attenuation of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced rhabdomyolysis with alpha1- plus beta3-adrenoreceptor antagonists. Sprague, J.E., Brutcher, R.E., Mills, E.M., Caden, D., Rusyniak, D.E. Br. J. Pharmacol. (2004) [Pubmed]
  6. Characterization of a novel iodocyanopindolol and SM-11044 binding protein, which may mediate relaxation of depolarized rat colon tonus. Sugasawa, T., Matsuzaki-Fujita, M., Guillaume, J.L., Camoin, L., Morooka, S., Strosberg, A.D. J. Biol. Chem. (1997) [Pubmed]
  7. Thermoregulatory and cardiac responses of infant spontaneously hypertensive and Wistar-Kyoto rats to cold exposure. Kirby, R.F., Sokoloff, G., Perdomo, E., Blumberg, M.S. Hypertension (1999) [Pubmed]
  8. Selective up-regulation of alpha1a-adrenergic receptor protein and mRNA in brown adipose tissue by neural and beta3-adrenergic stimulation. Granneman, J.G., Zhai, Y., Lahners, K.N. Mol. Pharmacol. (1997) [Pubmed]
  9. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes. Nisoli, E., Tonello, C., Landi, M., Carruba, M.O. Mol. Pharmacol. (1996) [Pubmed]
  10. The beta 3-adrenoceptor agonist CL316243 prevents indomethacin-induced jejunal ulceration in the rat by reversing early villous shortening. Anthony, A., Bahl, A.K., Oakley, I.G., Spraggs, C.F., Dhillon, A.P., Trevethick, M.A., Piasecki, C., Pounder, R.E., Wakefield, A.J. J. Pathol. (1996) [Pubmed]
  11. Effect of SR 58611A, a beta-3 receptor agonist, against experimental gastro-duodenal ulcers. Vinay, H.K., Paul, A., Goswami, S.S., Santani, D. Indian J. Physiol. Pharmacol. (2002) [Pubmed]
  12. beta3-Adrenergic-dependent and -independent mechanisms participate in cold-induced modulation of insulin signal transduction in brown adipose tissue of rats. Gasparetti, A.L., Alvarez-Rojas, F., de Araujo, E.P., Hirata, A.E., Saad, M.J., Velloso, L.A. Pflugers Arch. (2005) [Pubmed]
  13. Adipose tissues from various anatomical sites are characterized by different patterns of gene expression and regulation. Cousin, B., Casteilla, L., Dani, C., Muzzin, P., Revelli, J.P., Penicaud, L. Biochem. J. (1993) [Pubmed]
  14. Beta 3-adrenoceptor stimulation induces vasorelaxation mediated essentially by endothelium-derived nitric oxide in rat thoracic aorta. Trochu, J.N., Leblais, V., Rautureau, Y., Bévérelli, F., Le Marec, H., Berdeaux, A., Gauthier, C. Br. J. Pharmacol. (1999) [Pubmed]
  15. Mediation of the positive chronotropic effect of CGP 12177 and cyanopindolol in the pithed rat by atypical beta-adrenoceptors, different from beta 3-adrenoceptors. Malinowska, B., Schlicker, E. Br. J. Pharmacol. (1996) [Pubmed]
  16. Characterization of a new, highly specific, beta 3-adrenergic receptor radioligand, [3H]SB 206606. Muzzin, P., Boss, O., Mathis, N., Revelli, J.P., Giacobino, J.P., Willcocks, K., Badman, G.T., Cantello, B.C., Hindley, R.M., Cawthorne, M.A. Mol. Pharmacol. (1994) [Pubmed]
  17. Differential adrenergic regulation of beta 1- and beta 3-adrenoreceptor messenger ribonucleic acids in adipose tissues. Granneman, J.G., Lahners, K.N. Endocrinology (1992) [Pubmed]
  18. Characteristics of cyanopindolol analogues active at the beta 3-adrenoceptor in rat ileum. Hoey, A.J., Jackson, C.M., Pegg, G.G., Sillence, M.N. Br. J. Pharmacol. (1996) [Pubmed]
  19. Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle. Li, F., De Godoy, M., Rattan, S. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  20. Influence of adrenodemedullation on beta 2- and beta 3-adrenoceptors mediating relaxation of oesophageal smooth muscle of spontaneously hypertensive rats. de Boer, R.E., Steegstra, M.R., Kroezen, P.A., Smit, J., Zaagsma, J. Br. J. Pharmacol. (1996) [Pubmed]
  21. Adrenergic activation of vascular endothelial growth factor mRNA expression in rat brown adipose tissue: implication in cold-induced angiogenesis. Asano, A., Morimatsu, M., Nikami, H., Yoshida, T., Saito, M. Biochem. J. (1997) [Pubmed]
  22. Early alterations in the brown adipose tissue adenylate cyclase system of pre-obese Zucker rat fa/fa pups: decreased G-proteins and beta 3-adrenoceptor activities. Charon, C., Krief, S., Diot-Dupuy, F., Strosberg, A.D., Emorine, L.J., Bazin, R. Biochem. J. (1995) [Pubmed]
  23. Rat frontal cortex beta 1-adrenoceptors are activated by the beta 3-adrenoceptor agonists SR 58611A and SR 58878A but not by BRL 37344 or ICI 215,001. Nisoli, E., Tonello, C., Benarese, M., Carruba, M.O. J. Neurochem. (1995) [Pubmed]
  24. Dietary vitamin A supplementation in rats: suppression of leptin and induction of UCP1 mRNA. Kumar, M.V., Sunvold, G.D., Scarpace, P.J. J. Lipid Res. (1999) [Pubmed]
  25. The beta 3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes. Gettys, T.W., Harkness, P.J., Watson, P.M. Endocrinology (1996) [Pubmed]
  26. Suppression of insulin-stimulated phosphatidylinositol 3-kinase activity by the beta3-adrenoceptor agonist CL316243 in rat adipocytes. Ohsaka, Y., Tokumitsu, Y., Nomura, Y. FEBS Lett. (1997) [Pubmed]
  27. Leptin, but not a beta 3-adrenergic agonist, upregulates muscle uncoupling protein-3 messenger RNA expression: short-term thermogenic interactions. Gómez-Ambrosi, J., Frühbeck, G., Martínez, J.A. Cell. Mol. Life Sci. (1999) [Pubmed]
  28. Peripheral injection of risperidone, an atypical antipsychotic, alters the bodyweight gain of rats. Ota, M., Mori, K., Nakashima, A., Kaneko, Y.S., Fujiwara, K., Itoh, M., Nagasaka, A., Ota, A. Clin. Exp. Pharmacol. Physiol. (2002) [Pubmed]
  29. Rat brown adipose tissue thermogenic features are altered during mid-pregnancy. Frontera, M., Pujol, E., Rodríguez-Cuenca, S., Català-Niell, A., Roca, P., García-Palmer, F.J., Gianotti, M. Cell. Physiol. Biochem. (2005) [Pubmed]
  30. The beta-adrenoceptor selectivity profile of BRL 37344 in the pithed rat. Oriowo, M.A., Sennitt, M.V., Smith, S.A., Ruffolo, R.R., Cawthorne, M.A. Journal of autonomic pharmacology. (1994) [Pubmed]
  31. Molecular cloning and expression of the rat beta 3-adrenergic receptor. Granneman, J.G., Lahners, K.N., Chaudhry, A. Mol. Pharmacol. (1991) [Pubmed]
  32. Interaction of amiodarone and triiodothyronine on the expression of beta-adrenoceptors in brown adipose tissue of rat. Adli, H., Bazin, R., Perret, G.Y. Br. J. Pharmacol. (1999) [Pubmed]
  33. Expression of beta 3-adrenoceptor mRNA in rat brain. Summers, R.J., Papaioannou, M., Harris, S., Evans, B.A. Br. J. Pharmacol. (1995) [Pubmed]
  34. Stereoselective action of (R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2-(3-chlorophenyl)ethylamino] propyl]-phenoxyacetic acid (BRL37344) on beta-adrenoceptors and metabolic chiral inversion. Ida, K., Hashimoto, K., Kamiya, M., Muto, S., Nakamura, Y., Kato, K., Mizota, M. Biochem. Pharmacol. (1996) [Pubmed]
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